A novel ginseng saponin metabolite induces apoptosis and down-regulates fibroblast growth factor receptor 3 in myeloma cells

  • Authors:
    • Hyun Ho Choi
    • Hyun-Soon Jong
    • Jung-Hyun Park
    • Seongwon Choi
    • Jung Weon Lee
    • Tae-You Kim
    • Takemi Otsuki
    • Masayoshi Namba
    • Yung-Jue Bang
  • View Affiliations

  • Published online on: October 1, 2003     https://doi.org/10.3892/ijo.23.4.1087
  • Pages:1087-1093
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Abstract

Ginseng (the root of Panax ginseng C.A. Meyer, Araliaceae) has been used as a crude drug taken orally for preventive and therapeutic purposes in Asian countries as a traditional medicine. In the current study, we have investigated the antitumor effect of a novel ginseng protopanaxadiol saponin bacterial metabolic derivative, 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol (IH-901), in eight human myeloma cell lines. IH-901 inhibited the proliferation of all myeloma cell lines examined. Despite the fibroblast growth factor receptor 3 (FGFR3) overexpression due to a chromosomal translocation t(4;14)(q16.3;q32.3) in KMS-11 myeloma cells, IH-901 induced apoptosis in a dose- and time-dependent way in this cell line. Treatment of KMS-11 with IH-901 resulted in the formation of internucleosomal DNA fragments, poly (ADP-ribose) polymerase cleavage, and the activation of caspase-3. IH-901 also caused the down-regulation of FGFR3 mRNA and protein expression and inhibited ERK activity in KMS-11 cells. Our results demonstrate that IH-901 induces apoptosis and inhibits FGFR3 expression and signaling in KMS-11 cells, suggesting candidacy for the chemoprevention and the treatment of myeloma.

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October 2003
Volume 23 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Choi, H.H., Jong, H., Park, J., Choi, S., Lee, J.W., Kim, T. ... Bang, Y. (2003). A novel ginseng saponin metabolite induces apoptosis and down-regulates fibroblast growth factor receptor 3 in myeloma cells. International Journal of Oncology, 23, 1087-1093. https://doi.org/10.3892/ijo.23.4.1087
MLA
Choi, H. H., Jong, H., Park, J., Choi, S., Lee, J. W., Kim, T., Otsuki, T., Namba, M., Bang, Y."A novel ginseng saponin metabolite induces apoptosis and down-regulates fibroblast growth factor receptor 3 in myeloma cells". International Journal of Oncology 23.4 (2003): 1087-1093.
Chicago
Choi, H. H., Jong, H., Park, J., Choi, S., Lee, J. W., Kim, T., Otsuki, T., Namba, M., Bang, Y."A novel ginseng saponin metabolite induces apoptosis and down-regulates fibroblast growth factor receptor 3 in myeloma cells". International Journal of Oncology 23, no. 4 (2003): 1087-1093. https://doi.org/10.3892/ijo.23.4.1087