Pre- and post-operative adjuvant chemotherapy in colorectal cancer

Isomoto,Hiroharu; Tomita,Masao; Sugimachi,Keizo; Ogawa,Michio; Yamada,Kazutaka; Nakagoe,Tohru; Mori,Masaki; Takano,Sadamu; Kakegawa,Teruo

doi:10.3892/ijo.23.4.1103

October 2003 Volume 23 Issue 4

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October 2003 Volume 23 Issue 4

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Article

Pre- and post-operative adjuvant chemotherapy in colorectal cancer

Authors:
- Hiroharu Isomoto
- Masao Tomita
- Keizo Sugimachi
- Michio Ogawa
- Kazutaka Yamada
- Tohru Nakagoe
- Masaki Mori
- Sadamu Takano
- Teruo Kakegawa
View Affiliations / Copyright

Affiliations: Department of Surgery, Kurume University Medical Center, Fukuoka 839-0863, Japan. isomoto@med.kurume-u.ac.jp
Pages: 1103-1108
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Published online on: October 1, 2003

https://doi.org/10.3892/ijo.23.4.1103
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Abstract

A multi-center randomized controlled study was conducted in order to investigate the usefulness of pre- and post-operative adjuvant chemotherapy in colorectal cancer. The patients were stratified into those with colon cancer and those with rectal cancer and divided into 2 groups, Group A and Group B. The patients in Group A received tegafur suppositories (750 mg/day) from 1 to 2 weeks prior to surgery, to 2 weeks following surgery and then oral administration of tegafur and uracil (UFT) (260 mg/m2) for 1 year. The patients in Group B, on the other hand, received only UFT (260 mg/m2) for 1 year beginning week 2 after surgery. Although there was no significant difference between Groups A and B in the 5-year survival rate, the 5-year disease-free survival rate was significantly higher in Group A, especially for rectal cancer (p<0.05). In addition, remote metastases tended to be suppressed for both colon and rectal cancer in Group A (p=0.08 and p=0.072). There was no serious adverse reaction to tegafur. Pre- and post-operative adjuvant chemotherapy with tegafur had fewer adverse reactions and was convenient to administer. Thus, it was considered useful for suppression of postoperative distant metastasis in colorectal cancer.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Pre- and post-operative adjuvant chemotherapy in colorectal cancer

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Abstract

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