A new prognostic scoring system involving des-γ-carboxy prothrombin as a useful marker for predicting prognosis in patients with hepatocellular carcinoma

  • Authors:
    • Tomoyuki Kawakita
    • Katsuya Shiraki
    • Yutaka Yamanaka
    • Yumi Yamaguchi
    • Yukiko Saitou
    • Naoyuki Enokimura
    • Norihiko Yamamoto
    • Hiroshi Okano
    • Kazushi Sugimoto
    • Kazumoto Murata
    • Koichirou Yamakado
    • Kan Takeda
    • Takeshi Nakano
  • View Affiliations

  • Published online on: October 1, 2003     https://doi.org/10.3892/ijo.23.4.1115
  • Pages: 1115-1120
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Abstract

A staging system for hepatocellular carcinoma was reported from Italy (CLIP). In this study, we evaluate the CLIP scoring system and establish a new scoring system for predicting the prognosis of patients with hepatocellular carcinoma. Patients (n=141) who were diagnosed and who underwent initial treatment at our single institution were recruited retrospectively into this study. We evaluated markers for prognosis, using a stratified Cox proportional hazard regression model and Kaplan-Meier survival analysis. CLIP score differentiated patients with different survival experiences by Kaplan-Meier estimated survival analysis. However, with respect the CLIP score, more than two thirds of patients were included in the early stage (CLIP 0-1), and the group with better prognosis than the survival rate of all patients was the only one with CLIP 0. Multivariate analysis revealed that des-γ-carboxy prothrombin (DCP) ≥100 mAU/ml (relative risk, 2.06; P=0.0218) was statistically significant as a predictor of poor survival. A new prognostic scoring system included DCP classified patients to 6 well-balanced groups (score 0-5). The new prognostic scoring system 0 group (14.9% of the cohort) and the CLIP score 0 group (34.0% of the cohort) had a median survival of 66.9 and 61.6 months. The new prognostic scoring system performs better for prediction of survival than either the CLIP score or the Child-Pugh stage. In conclusion, the described scoring system provides more accurate prognostic information than the CLIP scoring system. It may help physicians decide more appropriate clinical and therapeutic management.

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October 2003
Volume 23 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Kawakita T, Shiraki K, Yamanaka Y, Yamaguchi Y, Saitou Y, Enokimura N, Yamamoto N, Okano H, Sugimoto K, Murata K, Murata K, et al: A new prognostic scoring system involving des-γ-carboxy prothrombin as a useful marker for predicting prognosis in patients with hepatocellular carcinoma. Int J Oncol 23: 1115-1120, 2003.
APA
Kawakita, T., Shiraki, K., Yamanaka, Y., Yamaguchi, Y., Saitou, Y., Enokimura, N. ... Nakano, T. (2003). A new prognostic scoring system involving des-γ-carboxy prothrombin as a useful marker for predicting prognosis in patients with hepatocellular carcinoma. International Journal of Oncology, 23, 1115-1120. https://doi.org/10.3892/ijo.23.4.1115
MLA
Kawakita, T., Shiraki, K., Yamanaka, Y., Yamaguchi, Y., Saitou, Y., Enokimura, N., Yamamoto, N., Okano, H., Sugimoto, K., Murata, K., Yamakado, K., Takeda, K., Nakano, T."A new prognostic scoring system involving des-γ-carboxy prothrombin as a useful marker for predicting prognosis in patients with hepatocellular carcinoma". International Journal of Oncology 23.4 (2003): 1115-1120.
Chicago
Kawakita, T., Shiraki, K., Yamanaka, Y., Yamaguchi, Y., Saitou, Y., Enokimura, N., Yamamoto, N., Okano, H., Sugimoto, K., Murata, K., Yamakado, K., Takeda, K., Nakano, T."A new prognostic scoring system involving des-γ-carboxy prothrombin as a useful marker for predicting prognosis in patients with hepatocellular carcinoma". International Journal of Oncology 23, no. 4 (2003): 1115-1120. https://doi.org/10.3892/ijo.23.4.1115