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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2003 Volume 23 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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December 2003 Volume 23 Issue 6

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Article

Analysis of gene-expression profiles in testicular seminomas using a genome-wide cDNA microarray

  • Authors:
    • Koichi Okada
    • Toyomasa Katagiri
    • Tatsuhiko Tsunoda
    • Yoichi Mizutani
    • Yasushi Suzuki
    • Masayuki Kamada
    • Tomoaki Fujioka
    • Taro Shuin
    • Tsuneharu Miki
    • Yusuke Nakamura

  • View Affiliations / Copyright

    Affiliations: Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
  • Pages: 1615-1635
    |
    Published online on: December 1, 2003
       https://doi.org/10.3892/ijo.23.6.1615
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Abstract

To identify new diagnostic markers for testicular germ cell tumors (TGCTs), including seminomas, as well as potential targets of new drugs for treating the disease, we compared gene-expression profiles of cancer cells from 13 seminomas with normal human testis using laser-capture microdissection and a cDNA microarray representing 23,040 genes. We identified 347 genes that were commonly up-regulated in seminoma cells. The functions of 227 were known to some extent; the remaining 120 included 55 ESTs. On the list were cyclin D2 (CCND2), prostate cancer over-expressed gene 1 (POV1), and junction plakoglobin (JUP), all of which were already known to be over-expressed in seminomas. On the other hand, our protocol selected 593 genes as being commonly down-regulated in seminoma cells. That list included 340 functionally characterized genes; the other 253 included 131 ESTs. To confirm the expression data, we performed semi-quantitative RT-PCR experiments with nine highly up-regulated genes, and the results supported those of our microarray analysis. The information provided here should prove useful for identifying genes whose products might serve as molecular targets for treatment of TGCTs.

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Copy and paste a formatted citation
Spandidos Publications style
Okada K, Katagiri T, Tsunoda T, Mizutani Y, Suzuki Y, Kamada M, Fujioka T, Shuin T, Miki T, Nakamura Y, Nakamura Y, et al: Analysis of gene-expression profiles in testicular seminomas using a genome-wide cDNA microarray. Int J Oncol 23: 1615-1635, 2003.
APA
Okada, K., Katagiri, T., Tsunoda, T., Mizutani, Y., Suzuki, Y., Kamada, M. ... Nakamura, Y. (2003). Analysis of gene-expression profiles in testicular seminomas using a genome-wide cDNA microarray. International Journal of Oncology, 23, 1615-1635. https://doi.org/10.3892/ijo.23.6.1615
MLA
Okada, K., Katagiri, T., Tsunoda, T., Mizutani, Y., Suzuki, Y., Kamada, M., Fujioka, T., Shuin, T., Miki, T., Nakamura, Y."Analysis of gene-expression profiles in testicular seminomas using a genome-wide cDNA microarray". International Journal of Oncology 23.6 (2003): 1615-1635.
Chicago
Okada, K., Katagiri, T., Tsunoda, T., Mizutani, Y., Suzuki, Y., Kamada, M., Fujioka, T., Shuin, T., Miki, T., Nakamura, Y."Analysis of gene-expression profiles in testicular seminomas using a genome-wide cDNA microarray". International Journal of Oncology 23, no. 6 (2003): 1615-1635. https://doi.org/10.3892/ijo.23.6.1615
Copy and paste a formatted citation
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Spandidos Publications style
Okada K, Katagiri T, Tsunoda T, Mizutani Y, Suzuki Y, Kamada M, Fujioka T, Shuin T, Miki T, Nakamura Y, Nakamura Y, et al: Analysis of gene-expression profiles in testicular seminomas using a genome-wide cDNA microarray. Int J Oncol 23: 1615-1635, 2003.
APA
Okada, K., Katagiri, T., Tsunoda, T., Mizutani, Y., Suzuki, Y., Kamada, M. ... Nakamura, Y. (2003). Analysis of gene-expression profiles in testicular seminomas using a genome-wide cDNA microarray. International Journal of Oncology, 23, 1615-1635. https://doi.org/10.3892/ijo.23.6.1615
MLA
Okada, K., Katagiri, T., Tsunoda, T., Mizutani, Y., Suzuki, Y., Kamada, M., Fujioka, T., Shuin, T., Miki, T., Nakamura, Y."Analysis of gene-expression profiles in testicular seminomas using a genome-wide cDNA microarray". International Journal of Oncology 23.6 (2003): 1615-1635.
Chicago
Okada, K., Katagiri, T., Tsunoda, T., Mizutani, Y., Suzuki, Y., Kamada, M., Fujioka, T., Shuin, T., Miki, T., Nakamura, Y."Analysis of gene-expression profiles in testicular seminomas using a genome-wide cDNA microarray". International Journal of Oncology 23, no. 6 (2003): 1615-1635. https://doi.org/10.3892/ijo.23.6.1615
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