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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2003 Volume 23 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2003 Volume 23 Issue 6

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Article

The PLC-PKC cascade is required for IL-1β-dependent Erk and Akt activation: their role in proliferation

  • Authors:
    • A. R.M. Ruhul Amin
    • Yasukatu Ichigotani
    • Myat Lin Oo
    • M. Helal Uddin Biswas
    • Hong Yuan
    • Pengyu Huang
    • Naing Naing Mon
    • Michinari Hamaguchi

  • View Affiliations / Copyright

    Affiliations: Laboratory of Molecular Pathogenesis, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan
  • Pages: 1727-1731
    |
    Published online on: December 1, 2003
       https://doi.org/10.3892/ijo.23.6.1727
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Abstract

We investigated the signaling mechanisms that lead to IL-1β-induced cell proliferation. Treatment of Balb 3T3 cells with IL-1β activated two signaling pathways, Erk and Akt. IL-1β also increased tyrosine phosphorylation of PLC-γ in Src kinase-dependent manner. Pharmacological inhibition of the PLC-PKC cascade by using specific inhibitor for PLC-γ (U73122) and PKC (GFX) strongly inhibited IL-1β-induced Erk and Akt activation. Inhibition of MEK1 by its specific inhibitor, PD98059 substantially inhibited Erk activation. Similarly, inhibition of PI3K activation by its specific inhibitor LY294002 suppressed Akt phosphorylation. Moreover, IL-1β-induced association of PLC-γ with SHPS-1. SHPS-1 mutants lacking the tyrosine phosphorylation sites failed to associate with PLC-γ. Finally, IL-1β-induced proliferation of Balb 3T3 cells and inhibition of Erk and Akt signalings or their upstream signaling molecules, Src kinase and PKC by their inhibitors strongly inhibited IL-1β-dependent cell proliferation. Taken together, our results suggest that a SHPS-1-PLC-γ complex activate the PLC-PKC cascade, which is required for the activation of IL-1β-dependent Erk and Akt signalings and cell proliferation.

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Copy and paste a formatted citation
Spandidos Publications style
Amin AR, Ichigotani Y, Oo ML, Biswas MH, Yuan H, Huang P, Mon NN and Hamaguchi M: The PLC-PKC cascade is required for IL-1β-dependent Erk and Akt activation: their role in proliferation. Int J Oncol 23: 1727-1731, 2003.
APA
Amin, A.R., Ichigotani, Y., Oo, M.L., Biswas, M.H., Yuan, H., Huang, P. ... Hamaguchi, M. (2003). The PLC-PKC cascade is required for IL-1β-dependent Erk and Akt activation: their role in proliferation. International Journal of Oncology, 23, 1727-1731. https://doi.org/10.3892/ijo.23.6.1727
MLA
Amin, A. R., Ichigotani, Y., Oo, M. L., Biswas, M. H., Yuan, H., Huang, P., Mon, N. N., Hamaguchi, M."The PLC-PKC cascade is required for IL-1β-dependent Erk and Akt activation: their role in proliferation". International Journal of Oncology 23.6 (2003): 1727-1731.
Chicago
Amin, A. R., Ichigotani, Y., Oo, M. L., Biswas, M. H., Yuan, H., Huang, P., Mon, N. N., Hamaguchi, M."The PLC-PKC cascade is required for IL-1β-dependent Erk and Akt activation: their role in proliferation". International Journal of Oncology 23, no. 6 (2003): 1727-1731. https://doi.org/10.3892/ijo.23.6.1727
Copy and paste a formatted citation
x
Spandidos Publications style
Amin AR, Ichigotani Y, Oo ML, Biswas MH, Yuan H, Huang P, Mon NN and Hamaguchi M: The PLC-PKC cascade is required for IL-1β-dependent Erk and Akt activation: their role in proliferation. Int J Oncol 23: 1727-1731, 2003.
APA
Amin, A.R., Ichigotani, Y., Oo, M.L., Biswas, M.H., Yuan, H., Huang, P. ... Hamaguchi, M. (2003). The PLC-PKC cascade is required for IL-1β-dependent Erk and Akt activation: their role in proliferation. International Journal of Oncology, 23, 1727-1731. https://doi.org/10.3892/ijo.23.6.1727
MLA
Amin, A. R., Ichigotani, Y., Oo, M. L., Biswas, M. H., Yuan, H., Huang, P., Mon, N. N., Hamaguchi, M."The PLC-PKC cascade is required for IL-1β-dependent Erk and Akt activation: their role in proliferation". International Journal of Oncology 23.6 (2003): 1727-1731.
Chicago
Amin, A. R., Ichigotani, Y., Oo, M. L., Biswas, M. H., Yuan, H., Huang, P., Mon, N. N., Hamaguchi, M."The PLC-PKC cascade is required for IL-1β-dependent Erk and Akt activation: their role in proliferation". International Journal of Oncology 23, no. 6 (2003): 1727-1731. https://doi.org/10.3892/ijo.23.6.1727
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