Alterations in mitochondria function and morphology in HT29 cells upon conditions inducing differentiation and apoptosis

  • Authors:
    • Vlasta Sovová
    • Jitka Stokrová
    • Eva Sloncová
    • Dana Kucerová
    • Zdena Tuhácková
    • Jan Korb
  • View Affiliations

  • Published online on: December 1, 2003     https://doi.org/10.3892/ijo.23.6.1755
  • Pages: 1755-1760
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Abstract

Morphological and biochemical studies of HT29 cells treated with sodium butyrate and/or glucose-deprived revealed both apoptotic and differentiation response. The main apoptotic response was accompanied with an increase of floating cells. However, the ultrastructural analysis of adherent cells showed the typical apoptotic character of the nucleus in some of them. In addition, remarkable changes of mitochondria, assumed as early stages starting the apoptotic cascade, were observed. These changes were represented not only by alterations of mitochondrial morphology, but also by the number of mitochondria and their localization.

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December 2003
Volume 23 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Sovová V, Stokrová J, Sloncová E, Kucerová D, Tuhácková Z and Korb J: Alterations in mitochondria function and morphology in HT29 cells upon conditions inducing differentiation and apoptosis. Int J Oncol 23: 1755-1760, 2003
APA
Sovová, V., Stokrová, J., Sloncová, E., Kucerová, D., Tuhácková, Z., & Korb, J. (2003). Alterations in mitochondria function and morphology in HT29 cells upon conditions inducing differentiation and apoptosis. International Journal of Oncology, 23, 1755-1760. https://doi.org/10.3892/ijo.23.6.1755
MLA
Sovová, V., Stokrová, J., Sloncová, E., Kucerová, D., Tuhácková, Z., Korb, J."Alterations in mitochondria function and morphology in HT29 cells upon conditions inducing differentiation and apoptosis". International Journal of Oncology 23.6 (2003): 1755-1760.
Chicago
Sovová, V., Stokrová, J., Sloncová, E., Kucerová, D., Tuhácková, Z., Korb, J."Alterations in mitochondria function and morphology in HT29 cells upon conditions inducing differentiation and apoptosis". International Journal of Oncology 23, no. 6 (2003): 1755-1760. https://doi.org/10.3892/ijo.23.6.1755