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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2004 Volume 24 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2004 Volume 24 Issue 2

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Article

Genes associated with liver metastasis of colon cancer, identified by genome-wide cDNA microarray

  • Authors:
    • Meihua Li
    • Yu-Min Lin
    • Suguru Hasegawa
    • Takashi Shimokawa
    • Kohei Murata
    • Masao Kameyama
    • Osamu Ishikawa
    • Toyomasa Katagiri
    • Tatsuhiko Tsunoda
    • Yusuke Nakamura
    • Yoichi Furukawa

  • View Affiliations / Copyright

    Affiliations: Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan
  • Pages: 305-312
    |
    Published online on: February 1, 2004
       https://doi.org/10.3892/ijo.24.2.305
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Abstract

To uncover mechanisms underlying progression of colorectal carcinogenesis and to identify genes associated with liver metastasis, we analyzed expression profiles of 14 primary colorectal cancers (CRCs) with liver metastases, and compared them with profiles of 11 non-metastatic carcinomas and those of 9 adenomas of the colon. A hierarchical cluster analysis using data from a cDNA microarray containing 23,040 genes indicated that the cancers with metastasis had different expression profiles from those without metastasis, although a number of genes were commonly up-regulated in primary cancers of both categories. We documented 54 genes that were frequently up-regulated and 375 that were frequently down-regulated in primary tumors with metastases to liver, but not in tumors without metastasis. Subsequent quantitative PCR experiments confirmed that PRDX4, CKS2, MAGED2, and an EST (GenBank accession number BF696304) were expressed at significantly higher levels in tumors with metastasis. These data should contribute to a better understanding of the progression of colorectal tumors, and facilitate prediction of their metastatic potential.

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Copy and paste a formatted citation
Spandidos Publications style
Li M, Lin Y, Hasegawa S, Shimokawa T, Murata K, Kameyama M, Ishikawa O, Katagiri T, Tsunoda T, Nakamura Y, Nakamura Y, et al: Genes associated with liver metastasis of colon cancer, identified by genome-wide cDNA microarray. Int J Oncol 24: 305-312, 2004.
APA
Li, M., Lin, Y., Hasegawa, S., Shimokawa, T., Murata, K., Kameyama, M. ... Furukawa, Y. (2004). Genes associated with liver metastasis of colon cancer, identified by genome-wide cDNA microarray. International Journal of Oncology, 24, 305-312. https://doi.org/10.3892/ijo.24.2.305
MLA
Li, M., Lin, Y., Hasegawa, S., Shimokawa, T., Murata, K., Kameyama, M., Ishikawa, O., Katagiri, T., Tsunoda, T., Nakamura, Y., Furukawa, Y."Genes associated with liver metastasis of colon cancer, identified by genome-wide cDNA microarray". International Journal of Oncology 24.2 (2004): 305-312.
Chicago
Li, M., Lin, Y., Hasegawa, S., Shimokawa, T., Murata, K., Kameyama, M., Ishikawa, O., Katagiri, T., Tsunoda, T., Nakamura, Y., Furukawa, Y."Genes associated with liver metastasis of colon cancer, identified by genome-wide cDNA microarray". International Journal of Oncology 24, no. 2 (2004): 305-312. https://doi.org/10.3892/ijo.24.2.305
Copy and paste a formatted citation
x
Spandidos Publications style
Li M, Lin Y, Hasegawa S, Shimokawa T, Murata K, Kameyama M, Ishikawa O, Katagiri T, Tsunoda T, Nakamura Y, Nakamura Y, et al: Genes associated with liver metastasis of colon cancer, identified by genome-wide cDNA microarray. Int J Oncol 24: 305-312, 2004.
APA
Li, M., Lin, Y., Hasegawa, S., Shimokawa, T., Murata, K., Kameyama, M. ... Furukawa, Y. (2004). Genes associated with liver metastasis of colon cancer, identified by genome-wide cDNA microarray. International Journal of Oncology, 24, 305-312. https://doi.org/10.3892/ijo.24.2.305
MLA
Li, M., Lin, Y., Hasegawa, S., Shimokawa, T., Murata, K., Kameyama, M., Ishikawa, O., Katagiri, T., Tsunoda, T., Nakamura, Y., Furukawa, Y."Genes associated with liver metastasis of colon cancer, identified by genome-wide cDNA microarray". International Journal of Oncology 24.2 (2004): 305-312.
Chicago
Li, M., Lin, Y., Hasegawa, S., Shimokawa, T., Murata, K., Kameyama, M., Ishikawa, O., Katagiri, T., Tsunoda, T., Nakamura, Y., Furukawa, Y."Genes associated with liver metastasis of colon cancer, identified by genome-wide cDNA microarray". International Journal of Oncology 24, no. 2 (2004): 305-312. https://doi.org/10.3892/ijo.24.2.305
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