Detection of a set of peptide vaccine candidates for use in HLA-A31+ epithelial cancer patients

  • Authors:
    • Hiroko Takedatsu
    • Shigeki Shichijo
    • Kouichi Azuma
    • Hidetoshi Takedatsu
    • Michio Sata
    • Kyogo Itoh
  • View Affiliations

  • Published online on: February 1, 2004     https://doi.org/10.3892/ijo.24.2.337
  • Pages: 337-347
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Abstract

The molecular basis of host-tumor interaction in HLA-A31+ cancer patients has not been well understood. This lack of clarification is hampering the development of specific immunotherapies for these patients. This study aimed to identify a set of CTL-epitope peptides applicable for the specific immunotherapy of cancer patients with HLA-A31 allele. HLA-A31 allele is expressed in 5-10% of the world population, with the highest expression among Brazilian Amerinds (65%), and the lowest in the Eskimo population (0%). We report herein four cDNAs encoding CTL-epitopes and 7 epitope peptides with the ability to induce HLA-A31-restricted CTLs cytotoxic to tumor cell lines in the peripheral blood mononuclear cells of HLA-A31+ cancer patients. These peptides might be useful for the development of a peptide-based immunotherapy for HLA-A31+ cancer patients.

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February 2004
Volume 24 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Takedatsu H, Shichijo S, Azuma K, Takedatsu H, Sata M and Itoh K: Detection of a set of peptide vaccine candidates for use in HLA-A31+ epithelial cancer patients. Int J Oncol 24: 337-347, 2004.
APA
Takedatsu, H., Shichijo, S., Azuma, K., Takedatsu, H., Sata, M., & Itoh, K. (2004). Detection of a set of peptide vaccine candidates for use in HLA-A31+ epithelial cancer patients. International Journal of Oncology, 24, 337-347. https://doi.org/10.3892/ijo.24.2.337
MLA
Takedatsu, H., Shichijo, S., Azuma, K., Takedatsu, H., Sata, M., Itoh, K."Detection of a set of peptide vaccine candidates for use in HLA-A31+ epithelial cancer patients". International Journal of Oncology 24.2 (2004): 337-347.
Chicago
Takedatsu, H., Shichijo, S., Azuma, K., Takedatsu, H., Sata, M., Itoh, K."Detection of a set of peptide vaccine candidates for use in HLA-A31+ epithelial cancer patients". International Journal of Oncology 24, no. 2 (2004): 337-347. https://doi.org/10.3892/ijo.24.2.337