Percutaneous ethanol and lipiodol injection therapy for hepatocellular carcinoma

Kurokohchi,Kazutaka; Masaki,Tsutomu; Miyauchi,Yoshiaki; Funaki,Toshiharu; Yoneyama,Hirohito; Miyoshi,Hisaaki; Yoshida,Shuhei; Himoto,Takashi; Morishita,Asahiro; Uchida,Naohito; Watanabe,Seishiro; Kuriyama,Shigeki

doi:10.3892/ijo.24.2.381

February 2004 Volume 24 Issue 2

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February 2004 Volume 24 Issue 2

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Article

Percutaneous ethanol and lipiodol injection therapy for hepatocellular carcinoma

Authors:
- Kazutaka Kurokohchi
- Tsutomu Masaki
- Yoshiaki Miyauchi
- Toshiharu Funaki
- Hirohito Yoneyama
- Hisaaki Miyoshi
- Shuhei Yoshida
- Takashi Himoto
- Asahiro Morishita
- Naohito Uchida
- Seishiro Watanabe
- Shigeki Kuriyama
View Affiliations / Copyright

Affiliations: Third Department of Internal Medicine, Kagawa University School of Medicine, Miki-cho, Kita-gun, Kagawa 761-0793, Japan
Pages: 381-387
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Published online on: February 1, 2004

https://doi.org/10.3892/ijo.24.2.381
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Abstract

Radiofrequency ablation (RFA) therapy is of great significance in the treatment of hepatocellular carcinoma (HCC) or metastatic liver tumors. RFA is able to achieve widely coagulated necrosis in a few sessions without major complications. However, HCC cases exist that are resistant to RFA therapy for several reasons. In the present study, we performed injection of the mixture of ethanol and lipiodol (percutaneous ethanol-lipiodol injection therapy: PELIT) for HCCs that lacked clear visuality of the entire shape of the tumor by ultrasonography (US) or computed tomography (CT), or that were difficult to treat with RFA alone due to their locations in the liver or due to severe liver dysfunction of the patients. Local recurrence rates of HCC treated with PELIT were shown to be low in patients followed up for at least 4 months. In all patients treated with PELIT, lipiodol was accumulated in the entire region of the tumor after several trials of PELIT and the accumulation was kept for many months. The biopsy examination from the tumor treated with PELIT showed that HCC cells were totally destroyed by the PELIT. Although RFA therapy serves as a central role for the treatment of HCCs, PELIT, considered to be milder therapy, is likely to be important as a supportive treatment for HCCs and useful for the treatment of HCCs that are difficult to treat with RFA.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Percutaneous ethanol and lipiodol injection therapy for hepatocellular carcinoma

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Abstract

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