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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2004 Volume 24 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2004 Volume 24 Issue 4

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Article

Microarray analysis of differentially expressed genes associated with human ovarian cancer

  • Authors:
    • Byeong-Chel Lee
    • Kiweon Cha
    • Shalom Avraham
    • Hava Karsenty Avraham

  • View Affiliations / Copyright

    Affiliations: Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA, USA
  • Pages: 847-851
    |
    Published online on: April 1, 2004
       https://doi.org/10.3892/ijo.24.4.847
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Abstract

To define the molecular changes associated with ovarian cancer, DNA microarray analysis has been adapted to detect differentially expressed genes in human normal ovary tissue, borderline, and invasive epithelial ovarian tumors. The differential expression of genes in the tumor tissues and normal tissues was confirmed by Northern and/or semi-quantitative RT-PCR analysis. Analysis of the differential gene-expression profiles of the normal and neoplastic ovary allowed us to detect previously unidentified genes in ovarian tissues. We observed up-regulation of the following genes in ovarian cancer: catechol-O-methyltransferase (COMT), the autocrine motility factor neuroleukin (NLK), the transcription regulator high mobility group I proteins (HMGI), the tyrosine kinase receptor ErbB-3, S100-α protein and Acyl-CoA-binding protein (ACBP). The transcription factor, chicken ovalbumin up-stream promoter transcription factor II (COUP-TFII), was the only gene down-regulated in ovarian cancer. Comparable gene-expression profiles were previously reported in breast cancer, suggesting that similar molecular events also exist in ovarian cancer. Our microarray analysis showed that most differentially expressed genes in ovarian cancer are linked to glucose/insulin metabolism, providing a possible molecular link between the glucose/insulin signaling pathway and the neoplasms of ovarian cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Lee B, Cha K, Avraham S and Avraham HK: Microarray analysis of differentially expressed genes associated with human ovarian cancer. Int J Oncol 24: 847-851, 2004.
APA
Lee, B., Cha, K., Avraham, S., & Avraham, H.K. (2004). Microarray analysis of differentially expressed genes associated with human ovarian cancer. International Journal of Oncology, 24, 847-851. https://doi.org/10.3892/ijo.24.4.847
MLA
Lee, B., Cha, K., Avraham, S., Avraham, H. K."Microarray analysis of differentially expressed genes associated with human ovarian cancer". International Journal of Oncology 24.4 (2004): 847-851.
Chicago
Lee, B., Cha, K., Avraham, S., Avraham, H. K."Microarray analysis of differentially expressed genes associated with human ovarian cancer". International Journal of Oncology 24, no. 4 (2004): 847-851. https://doi.org/10.3892/ijo.24.4.847
Copy and paste a formatted citation
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Spandidos Publications style
Lee B, Cha K, Avraham S and Avraham HK: Microarray analysis of differentially expressed genes associated with human ovarian cancer. Int J Oncol 24: 847-851, 2004.
APA
Lee, B., Cha, K., Avraham, S., & Avraham, H.K. (2004). Microarray analysis of differentially expressed genes associated with human ovarian cancer. International Journal of Oncology, 24, 847-851. https://doi.org/10.3892/ijo.24.4.847
MLA
Lee, B., Cha, K., Avraham, S., Avraham, H. K."Microarray analysis of differentially expressed genes associated with human ovarian cancer". International Journal of Oncology 24.4 (2004): 847-851.
Chicago
Lee, B., Cha, K., Avraham, S., Avraham, H. K."Microarray analysis of differentially expressed genes associated with human ovarian cancer". International Journal of Oncology 24, no. 4 (2004): 847-851. https://doi.org/10.3892/ijo.24.4.847
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