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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2004 Volume 24 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2004 Volume 24 Issue 4

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Article

Wild-type p53 gene transfer into mutated p53 HT29 cells improves sensitivity to photodynamic therapy via induction of apoptosis

  • Authors:
    • Muriel Barberi-Heyob
    • Pierre-Olivier Védrine
    • Jean-Louis Merlin
    • Régine Millon
    • Joseph Abecassis
    • Marie-France Poupon
    • François Guillemin

  • View Affiliations / Copyright

    Affiliations: Centre Alexis Vautrin, Unité de Recherche en Thérapie Photodynamique, 54511 Vandœuvre-les-Nancy Cedex, France. m.barberi@nancy.fnclcc.fr
  • Pages: 951-958
    |
    Published online on: April 1, 2004
       https://doi.org/10.3892/ijo.24.4.951
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Abstract

Photodynamic therapy (PDT) is an effective local cancer treatment that induces cytotoxicity through the intracellular generation of reactive oxygen species. It is generally thought that p53 regulates chemotherapy and radiation therapy responsiveness via apoptosis induction control. The current study investigated whether cellular sensitivity to PDT is increased when a wild-type (wt) p53 status is restored by gene transfer in the established HT9blk Ala273-mutant p53 human colon cancer cell line. The photosensitizer accumulation was similar in both cell lines, and survival measurements using MTT test and clonogenic assays demonstrated that wt p53 transfected cells (HT29A4) were significantly more sensitive to chlorin e6-mediated PDT. P53 protein expression and its functionality as a transcription factor demonstrated through the induction of mdm2 transactivation, were not found to be directly involved in this differential photosensitivity. However, induction of caspase 3 activation (2.6-fold), leading to significant apoptosis induction 24-h after PDT was observed in HT29A4 cells. These results suggest that the introduction of wt p53 in HT29A4 potentiates the cell sensitivity to PDT through the induction of apoptosis in relation to p53 mutational status, but independently of p53 expression level and transcriptional activity.

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Copy and paste a formatted citation
Spandidos Publications style
Barberi-Heyob M, Védrine P, Merlin J, Millon R, Abecassis J, Poupon M and Guillemin F: Wild-type p53 gene transfer into mutated p53 HT29 cells improves sensitivity to photodynamic therapy via induction of apoptosis. Int J Oncol 24: 951-958, 2004.
APA
Barberi-Heyob, M., Védrine, P., Merlin, J., Millon, R., Abecassis, J., Poupon, M., & Guillemin, F. (2004). Wild-type p53 gene transfer into mutated p53 HT29 cells improves sensitivity to photodynamic therapy via induction of apoptosis. International Journal of Oncology, 24, 951-958. https://doi.org/10.3892/ijo.24.4.951
MLA
Barberi-Heyob, M., Védrine, P., Merlin, J., Millon, R., Abecassis, J., Poupon, M., Guillemin, F."Wild-type p53 gene transfer into mutated p53 HT29 cells improves sensitivity to photodynamic therapy via induction of apoptosis". International Journal of Oncology 24.4 (2004): 951-958.
Chicago
Barberi-Heyob, M., Védrine, P., Merlin, J., Millon, R., Abecassis, J., Poupon, M., Guillemin, F."Wild-type p53 gene transfer into mutated p53 HT29 cells improves sensitivity to photodynamic therapy via induction of apoptosis". International Journal of Oncology 24, no. 4 (2004): 951-958. https://doi.org/10.3892/ijo.24.4.951
Copy and paste a formatted citation
x
Spandidos Publications style
Barberi-Heyob M, Védrine P, Merlin J, Millon R, Abecassis J, Poupon M and Guillemin F: Wild-type p53 gene transfer into mutated p53 HT29 cells improves sensitivity to photodynamic therapy via induction of apoptosis. Int J Oncol 24: 951-958, 2004.
APA
Barberi-Heyob, M., Védrine, P., Merlin, J., Millon, R., Abecassis, J., Poupon, M., & Guillemin, F. (2004). Wild-type p53 gene transfer into mutated p53 HT29 cells improves sensitivity to photodynamic therapy via induction of apoptosis. International Journal of Oncology, 24, 951-958. https://doi.org/10.3892/ijo.24.4.951
MLA
Barberi-Heyob, M., Védrine, P., Merlin, J., Millon, R., Abecassis, J., Poupon, M., Guillemin, F."Wild-type p53 gene transfer into mutated p53 HT29 cells improves sensitivity to photodynamic therapy via induction of apoptosis". International Journal of Oncology 24.4 (2004): 951-958.
Chicago
Barberi-Heyob, M., Védrine, P., Merlin, J., Millon, R., Abecassis, J., Poupon, M., Guillemin, F."Wild-type p53 gene transfer into mutated p53 HT29 cells improves sensitivity to photodynamic therapy via induction of apoptosis". International Journal of Oncology 24, no. 4 (2004): 951-958. https://doi.org/10.3892/ijo.24.4.951
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