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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2004 Volume 24 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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An International Open Access Journal Devoted to General Medicine.

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June 2004 Volume 24 Issue 6

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Article

Stimulation of cells from a non-invaded and an invaded lymph node with a HER-2+ tumor with peptides corresponding to T-cell epitopes E75 and G89 induced expansion of central memory cells (TCM) from the metastasis-negative lymph nodes

  • Authors:
    • Byung K. Ko
    • Clay L. Efferson
    • Kouichiro Kawano
    • Henry M. Kuerer
    • Aysegul Sahin
    • James L. Murray
    • Constantin G. Ioannides

  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, College of Medicine, Ulsan University Hospital, Ulsan, Korea. kobyky59@yahoo.com
  • Pages: 1413-1418
    |
    Published online on: June 1, 2004
       https://doi.org/10.3892/ijo.24.6.1413
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Abstract

Breast cancer metastasizes from the primary site to the axillary lymph nodes (LN). It is unknown whether tumor metastasis abolishes or enhances the ability of LN cells to develop a specific response to the Ag expressed by the tumor, and whether an immune response to the same Ag is present in the tumor-free LN. We stimulated lymphocytes from a metastasis negative (Met−) and a metastasis positive (Met+) LN, invaded by a HER-2+ tumor, from the same patient, with HER-2 peptides E75 (369-377) and G89 (776-778). E75 define a CTL epitope presented by HLA-A2, while G89 define a CD4+ cell recognized epitope. Met− LN responded to E75+G89 with higher expansion of E75 TCR+ CD45RO+ CCR7− (CCR7−) and E75-TCR+ CD45RO+ CCR7+ (CCR7+) cells than Met+ LN. Stimulation with E75+G89 induced a significant increase in CCR7+ cells in Met− LN compared with Met+ LN. The levels of IFN-α and IL-15 were higher in Met− LN cultures stimulated with E75+G89 than in Met+ LN cultures. This increase did not correlate with the levels of induction of IFN-γ, IL-4, and IL-10. The finding of higher expansion of Ag specific CCR7+ cells and of differentiation to CCR7− cells, which define the TCM and TEM subsets respectively, in Met− LN, by G89 is novel for tumor systems. This may have implications for preventative vaccination strategies for breast and ovarian cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Ko BK, Efferson CL, Kawano K, Kuerer HM, Sahin A, Murray JL and Ioannides CG: Stimulation of cells from a non-invaded and an invaded lymph node with a HER-2+ tumor with peptides corresponding to T-cell epitopes E75 and G89 induced expansion of central memory cells (TCM) from the metastasis-negative lymph nodes. Int J Oncol 24: 1413-1418, 2004.
APA
Ko, B.K., Efferson, C.L., Kawano, K., Kuerer, H.M., Sahin, A., Murray, J.L., & Ioannides, C.G. (2004). Stimulation of cells from a non-invaded and an invaded lymph node with a HER-2+ tumor with peptides corresponding to T-cell epitopes E75 and G89 induced expansion of central memory cells (TCM) from the metastasis-negative lymph nodes. International Journal of Oncology, 24, 1413-1418. https://doi.org/10.3892/ijo.24.6.1413
MLA
Ko, B. K., Efferson, C. L., Kawano, K., Kuerer, H. M., Sahin, A., Murray, J. L., Ioannides, C. G."Stimulation of cells from a non-invaded and an invaded lymph node with a HER-2+ tumor with peptides corresponding to T-cell epitopes E75 and G89 induced expansion of central memory cells (TCM) from the metastasis-negative lymph nodes". International Journal of Oncology 24.6 (2004): 1413-1418.
Chicago
Ko, B. K., Efferson, C. L., Kawano, K., Kuerer, H. M., Sahin, A., Murray, J. L., Ioannides, C. G."Stimulation of cells from a non-invaded and an invaded lymph node with a HER-2+ tumor with peptides corresponding to T-cell epitopes E75 and G89 induced expansion of central memory cells (TCM) from the metastasis-negative lymph nodes". International Journal of Oncology 24, no. 6 (2004): 1413-1418. https://doi.org/10.3892/ijo.24.6.1413
Copy and paste a formatted citation
x
Spandidos Publications style
Ko BK, Efferson CL, Kawano K, Kuerer HM, Sahin A, Murray JL and Ioannides CG: Stimulation of cells from a non-invaded and an invaded lymph node with a HER-2+ tumor with peptides corresponding to T-cell epitopes E75 and G89 induced expansion of central memory cells (TCM) from the metastasis-negative lymph nodes. Int J Oncol 24: 1413-1418, 2004.
APA
Ko, B.K., Efferson, C.L., Kawano, K., Kuerer, H.M., Sahin, A., Murray, J.L., & Ioannides, C.G. (2004). Stimulation of cells from a non-invaded and an invaded lymph node with a HER-2+ tumor with peptides corresponding to T-cell epitopes E75 and G89 induced expansion of central memory cells (TCM) from the metastasis-negative lymph nodes. International Journal of Oncology, 24, 1413-1418. https://doi.org/10.3892/ijo.24.6.1413
MLA
Ko, B. K., Efferson, C. L., Kawano, K., Kuerer, H. M., Sahin, A., Murray, J. L., Ioannides, C. G."Stimulation of cells from a non-invaded and an invaded lymph node with a HER-2+ tumor with peptides corresponding to T-cell epitopes E75 and G89 induced expansion of central memory cells (TCM) from the metastasis-negative lymph nodes". International Journal of Oncology 24.6 (2004): 1413-1418.
Chicago
Ko, B. K., Efferson, C. L., Kawano, K., Kuerer, H. M., Sahin, A., Murray, J. L., Ioannides, C. G."Stimulation of cells from a non-invaded and an invaded lymph node with a HER-2+ tumor with peptides corresponding to T-cell epitopes E75 and G89 induced expansion of central memory cells (TCM) from the metastasis-negative lymph nodes". International Journal of Oncology 24, no. 6 (2004): 1413-1418. https://doi.org/10.3892/ijo.24.6.1413
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