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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2004 Volume 24 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2004 Volume 24 Issue 6

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Article

ERK activation and subsequent RB phosphorylation are important determinants of the sensitivity to paclitaxel in lung adenocarcinoma cells

  • Authors:
    • Hisashi Suyama
    • Tadashi Igishi
    • Hiroyuki Sano
    • Shingo Matsumoto
    • Yasushi Shigeoka
    • Hirofumi Nakanishi
    • Masahiro Endo
    • Naoto Burioka
    • Yutaka Hitsuda
    • Eiji Shimizu
  • View Affiliations / Copyright

    Affiliations: Division of Blood Transfusion, Faculty of Medicine, Tottori University, Yonago 683-8504, Japan
  • Pages: 1499-1504
    |
    Published online on: June 1, 2004
       https://doi.org/10.3892/ijo.24.6.1499
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Abstract

Paclitaxel is used frequently in the treatment of advanced non-small cell lung cancer. This study was carried out in order to determine the role of extracellular signal-regulated kinases (ERK) and retinoblastoma protein (pRB) in the governing mechanism resistance to paclitaxel using two lung adenocarcinoma cell lines with differing sensitivities. In paclitaxel-sensitive Ma-10 cells, treatment with paclitaxel induced pRB phosphorylation at Ser795 and ERK activation. In contrast, in paclitaxel-resistant Ma-31 cells, paclitaxel dephosphorylated pRB at Ser795 without affecting ERK activity. A specific ERK inhibitor, PD98059, blocked paclitaxel-induced ERK activation and pRB phosphorylation at Ser795 in Ma-10 cells. Furthermore, PD98059 inhibited cell cycle progression during paclitaxel treatment, the accumulation of sub-G1 population, and the cytotoxic effect by paclitaxel in Ma-10 cells, suggesting that ERK activation by paclitaxel, subsequent pRB phosphorylation, and the cell cycle progression during paclitaxel treatment are important determinants of sensitivity to paclitaxel. These observations raise the possibility that the promotion of cell cycle during the exposure of lung cancer cells to paclitaxel may sensitize resistant cells to paclitaxel.

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Copy and paste a formatted citation
Spandidos Publications style
Suyama H, Igishi T, Sano H, Matsumoto S, Shigeoka Y, Nakanishi H, Endo M, Burioka N, Hitsuda Y, Shimizu E, Shimizu E, et al: ERK activation and subsequent RB phosphorylation are important determinants of the sensitivity to paclitaxel in lung adenocarcinoma cells. Int J Oncol 24: 1499-1504, 2004.
APA
Suyama, H., Igishi, T., Sano, H., Matsumoto, S., Shigeoka, Y., Nakanishi, H. ... Shimizu, E. (2004). ERK activation and subsequent RB phosphorylation are important determinants of the sensitivity to paclitaxel in lung adenocarcinoma cells. International Journal of Oncology, 24, 1499-1504. https://doi.org/10.3892/ijo.24.6.1499
MLA
Suyama, H., Igishi, T., Sano, H., Matsumoto, S., Shigeoka, Y., Nakanishi, H., Endo, M., Burioka, N., Hitsuda, Y., Shimizu, E."ERK activation and subsequent RB phosphorylation are important determinants of the sensitivity to paclitaxel in lung adenocarcinoma cells". International Journal of Oncology 24.6 (2004): 1499-1504.
Chicago
Suyama, H., Igishi, T., Sano, H., Matsumoto, S., Shigeoka, Y., Nakanishi, H., Endo, M., Burioka, N., Hitsuda, Y., Shimizu, E."ERK activation and subsequent RB phosphorylation are important determinants of the sensitivity to paclitaxel in lung adenocarcinoma cells". International Journal of Oncology 24, no. 6 (2004): 1499-1504. https://doi.org/10.3892/ijo.24.6.1499
Copy and paste a formatted citation
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Spandidos Publications style
Suyama H, Igishi T, Sano H, Matsumoto S, Shigeoka Y, Nakanishi H, Endo M, Burioka N, Hitsuda Y, Shimizu E, Shimizu E, et al: ERK activation and subsequent RB phosphorylation are important determinants of the sensitivity to paclitaxel in lung adenocarcinoma cells. Int J Oncol 24: 1499-1504, 2004.
APA
Suyama, H., Igishi, T., Sano, H., Matsumoto, S., Shigeoka, Y., Nakanishi, H. ... Shimizu, E. (2004). ERK activation and subsequent RB phosphorylation are important determinants of the sensitivity to paclitaxel in lung adenocarcinoma cells. International Journal of Oncology, 24, 1499-1504. https://doi.org/10.3892/ijo.24.6.1499
MLA
Suyama, H., Igishi, T., Sano, H., Matsumoto, S., Shigeoka, Y., Nakanishi, H., Endo, M., Burioka, N., Hitsuda, Y., Shimizu, E."ERK activation and subsequent RB phosphorylation are important determinants of the sensitivity to paclitaxel in lung adenocarcinoma cells". International Journal of Oncology 24.6 (2004): 1499-1504.
Chicago
Suyama, H., Igishi, T., Sano, H., Matsumoto, S., Shigeoka, Y., Nakanishi, H., Endo, M., Burioka, N., Hitsuda, Y., Shimizu, E."ERK activation and subsequent RB phosphorylation are important determinants of the sensitivity to paclitaxel in lung adenocarcinoma cells". International Journal of Oncology 24, no. 6 (2004): 1499-1504. https://doi.org/10.3892/ijo.24.6.1499
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