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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2004 Volume 24 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2004 Volume 24 Issue 6

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Article

Therapeutic effects of novel anti-tumor reagent, apoptosis inducing nucleosides from CD57+HLA-DRbright natural suppressor cell line on human gastric carcinoma-bearing SCID mice

  • Authors:
    • Aishun Jin
    • Yunlong Qi
    • Etsuko Mori
    • Maowu Guo
    • Seiichi Takasaki
    • Tsuneatsu Mori
  • View Affiliations / Copyright

    Affiliations: Departments of Immunology and Biochemistry, Institute of Medical Science, University of Tokyo, Tokyo, Japan
  • Pages: 1523-1528
    |
    Published online on: June 1, 2004
       https://doi.org/10.3892/ijo.24.6.1523
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Abstract

To further provide scientific evidence before clinical application, the anti-tumor effects of apoptosis inducing nucleosides (AINs) released from CD57+HLA-DRbright natural suppressor (CD57.DR-NS) cell line on human gastric carcinoma (GCIY)-bearing severe combined immunodeficiency (SCID) mice were examined by monitoring tumor cell growth and change of body weight of mice. The results obtained evidenced that AINs strongly induced apoptosis in the tumor tissues in SCID mice with decrease of tumor size and without loss of body weight. We found that peak 5 and peak 6 (P5 and P6) components among six components (AINs) isolated from CD57.DR-NS cell cultures by high performance liquid chromatograhy (HPLC) are the most effective. The anti-tumor effective dosage of P5, P6 and their mixture, P5+P6, were obtained in dose-dependent manner. Thus, the most effective method of administration of AINs for tumor regression without exhaustion was established in the present study. Corresponding to the previous study that AINs could generate apoptosis in malignant cells while lacking the toxicity in normal cells, the results obtained in the present preclinical experiments suggested anti-tumor efficacy of AINs with possible refrainment from side-effects in clinical trials.

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Copy and paste a formatted citation
Spandidos Publications style
Jin A, Qi Y, Mori E, Guo M, Takasaki S and Mori T: Therapeutic effects of novel anti-tumor reagent, apoptosis inducing nucleosides from CD57+HLA-DRbright natural suppressor cell line on human gastric carcinoma-bearing SCID mice. Int J Oncol 24: 1523-1528, 2004.
APA
Jin, A., Qi, Y., Mori, E., Guo, M., Takasaki, S., & Mori, T. (2004). Therapeutic effects of novel anti-tumor reagent, apoptosis inducing nucleosides from CD57+HLA-DRbright natural suppressor cell line on human gastric carcinoma-bearing SCID mice. International Journal of Oncology, 24, 1523-1528. https://doi.org/10.3892/ijo.24.6.1523
MLA
Jin, A., Qi, Y., Mori, E., Guo, M., Takasaki, S., Mori, T."Therapeutic effects of novel anti-tumor reagent, apoptosis inducing nucleosides from CD57+HLA-DRbright natural suppressor cell line on human gastric carcinoma-bearing SCID mice". International Journal of Oncology 24.6 (2004): 1523-1528.
Chicago
Jin, A., Qi, Y., Mori, E., Guo, M., Takasaki, S., Mori, T."Therapeutic effects of novel anti-tumor reagent, apoptosis inducing nucleosides from CD57+HLA-DRbright natural suppressor cell line on human gastric carcinoma-bearing SCID mice". International Journal of Oncology 24, no. 6 (2004): 1523-1528. https://doi.org/10.3892/ijo.24.6.1523
Copy and paste a formatted citation
x
Spandidos Publications style
Jin A, Qi Y, Mori E, Guo M, Takasaki S and Mori T: Therapeutic effects of novel anti-tumor reagent, apoptosis inducing nucleosides from CD57+HLA-DRbright natural suppressor cell line on human gastric carcinoma-bearing SCID mice. Int J Oncol 24: 1523-1528, 2004.
APA
Jin, A., Qi, Y., Mori, E., Guo, M., Takasaki, S., & Mori, T. (2004). Therapeutic effects of novel anti-tumor reagent, apoptosis inducing nucleosides from CD57+HLA-DRbright natural suppressor cell line on human gastric carcinoma-bearing SCID mice. International Journal of Oncology, 24, 1523-1528. https://doi.org/10.3892/ijo.24.6.1523
MLA
Jin, A., Qi, Y., Mori, E., Guo, M., Takasaki, S., Mori, T."Therapeutic effects of novel anti-tumor reagent, apoptosis inducing nucleosides from CD57+HLA-DRbright natural suppressor cell line on human gastric carcinoma-bearing SCID mice". International Journal of Oncology 24.6 (2004): 1523-1528.
Chicago
Jin, A., Qi, Y., Mori, E., Guo, M., Takasaki, S., Mori, T."Therapeutic effects of novel anti-tumor reagent, apoptosis inducing nucleosides from CD57+HLA-DRbright natural suppressor cell line on human gastric carcinoma-bearing SCID mice". International Journal of Oncology 24, no. 6 (2004): 1523-1528. https://doi.org/10.3892/ijo.24.6.1523
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