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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2004 Volume 24 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2004 Volume 24 Issue 6

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Article

Assessment of the antiinvasive potential of the anthracycline aclacinomycin (Aclarubicin®) in a human fibrosarcoma cell line

  • Authors:
    • Salima Addadi-Rebbah
    • Stephane Poitevin
    • Nicolas Fourre
    • Myriam Polette
    • Roselyne Garnotel
    • Pierre Jeannesson

  • View Affiliations / Copyright

    Affiliations: Unité MéDIAN CNRS UMR 6142, UFR de Pharmacie, F-51096 Reims Cedex, France
  • Pages: 1607-1615
    |
    Published online on: June 1, 2004
       https://doi.org/10.3892/ijo.24.6.1607
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Abstract

Aclacinomycin (Aclarubicin®) is a trisaccharide anthracycline anticancer drug active against a wide variety of solid tumors and haematological malignancies. We have evaluated its antimigrative and antiinvasive properties in a Boyden chamber with or without Matrigel and in wound repair assays. Aclacinomycin was demonstrated to inhibit HT-1080 cell migration and invasion while being more potent than the classical anthracycline doxorubicin. This decrease occurred in a dose-dependent manner and without affecting cell proliferation. Importantly, the antiinvasive effect was not associated to a modification in the production of the matrix-degrading enzymes MMP-2 and MMP-9 but rather to changes in cytoskeletal and focal contact formation. Indeed, the drug reduces cell polarity, impairs the actin-mediated membrane ruffling at the leading edge and decreases β1 integrin expression and activation. Dramatic alterations in the distribution of vinculin and in the expression and phosphorylation state of both FAK and Src kinases were also detected. As a conclusion, these data suggest a novel application for this chemotherapeutic agent due to its ability to reduce tumor cell invasion. Combination of aclacinomycin with MMP inhibitors could have therapeutic potential in preventing tumor metastasis.

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Copy and paste a formatted citation
Spandidos Publications style
Addadi-Rebbah S, Poitevin S, Fourre N, Polette M, Garnotel R and Jeannesson P: Assessment of the antiinvasive potential of the anthracycline aclacinomycin (Aclarubicin®) in a human fibrosarcoma cell line. Int J Oncol 24: 1607-1615, 2004.
APA
Addadi-Rebbah, S., Poitevin, S., Fourre, N., Polette, M., Garnotel, R., & Jeannesson, P. (2004). Assessment of the antiinvasive potential of the anthracycline aclacinomycin (Aclarubicin®) in a human fibrosarcoma cell line. International Journal of Oncology, 24, 1607-1615. https://doi.org/10.3892/ijo.24.6.1607
MLA
Addadi-Rebbah, S., Poitevin, S., Fourre, N., Polette, M., Garnotel, R., Jeannesson, P."Assessment of the antiinvasive potential of the anthracycline aclacinomycin (Aclarubicin®) in a human fibrosarcoma cell line". International Journal of Oncology 24.6 (2004): 1607-1615.
Chicago
Addadi-Rebbah, S., Poitevin, S., Fourre, N., Polette, M., Garnotel, R., Jeannesson, P."Assessment of the antiinvasive potential of the anthracycline aclacinomycin (Aclarubicin®) in a human fibrosarcoma cell line". International Journal of Oncology 24, no. 6 (2004): 1607-1615. https://doi.org/10.3892/ijo.24.6.1607
Copy and paste a formatted citation
x
Spandidos Publications style
Addadi-Rebbah S, Poitevin S, Fourre N, Polette M, Garnotel R and Jeannesson P: Assessment of the antiinvasive potential of the anthracycline aclacinomycin (Aclarubicin®) in a human fibrosarcoma cell line. Int J Oncol 24: 1607-1615, 2004.
APA
Addadi-Rebbah, S., Poitevin, S., Fourre, N., Polette, M., Garnotel, R., & Jeannesson, P. (2004). Assessment of the antiinvasive potential of the anthracycline aclacinomycin (Aclarubicin®) in a human fibrosarcoma cell line. International Journal of Oncology, 24, 1607-1615. https://doi.org/10.3892/ijo.24.6.1607
MLA
Addadi-Rebbah, S., Poitevin, S., Fourre, N., Polette, M., Garnotel, R., Jeannesson, P."Assessment of the antiinvasive potential of the anthracycline aclacinomycin (Aclarubicin®) in a human fibrosarcoma cell line". International Journal of Oncology 24.6 (2004): 1607-1615.
Chicago
Addadi-Rebbah, S., Poitevin, S., Fourre, N., Polette, M., Garnotel, R., Jeannesson, P."Assessment of the antiinvasive potential of the anthracycline aclacinomycin (Aclarubicin®) in a human fibrosarcoma cell line". International Journal of Oncology 24, no. 6 (2004): 1607-1615. https://doi.org/10.3892/ijo.24.6.1607
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