Evidence for existence of oligoclonal tumor-infiltrating lymphocytes and predominant production of T helper 1/T cytotoxic 1 type cytokines in gastric and colorectal tumors

Matsutani,Takaji; Shiiba,Ken-Ichi; Yoshioka,Takeshi; Tsuruta,Yuji; Suzuki,Ryuji; Ochi,Takahiro; Itoh,Tsunetoshi; Musha,Hiroaki; Mizoi,Takayuki; Sasaki,Iwao

doi:10.3892/ijo.25.1.133

July 2004 Volume 25 Issue 1

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July 2004 Volume 25 Issue 1

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Article

Evidence for existence of oligoclonal tumor-infiltrating lymphocytes and predominant production of T helper 1/T cytotoxic 1 type cytokines in gastric and colorectal tumors

Authors:
- Takaji Matsutani
- Ken-Ichi Shiiba
- Takeshi Yoshioka
- Yuji Tsuruta
- Ryuji Suzuki
- Takahiro Ochi
- Tsunetoshi Itoh
- Hiroaki Musha
- Takayuki Mizoi
- Iwao Sasaki
View Affiliations / Copyright

Affiliations: Division of Immunology and Embryology, Department of Cell Biology, Tohoku University School of Medicine, Sendai 980-8575, Japan. matsu@immem.med.tohoku.ac.jp
Pages: 133-141
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Published online on: July 1, 2004

https://doi.org/10.3892/ijo.25.1.133
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Abstract

Tumor-infiltrating lymphocytes (TIL) play a central role in cellular immunity against tumor. We have revealed the characteristics of TILs in terms of T-cell receptor (TCR) repertoire, T-cell clonality, and cytokine production. TCR repertoire analyses and CDR3 size spectratyping were performed using peripheral blood mononuclear cells (PBMCs) and tissue specimens of gastric or colorectal cancers surgically resected from 11 patients. The cytokine expression was measured by real-time quantitative polymerase chain reaction. TCR repertoires were similar among multiple tissue specimens from different sites of the same tumor. Similar peak patterns of CDR3 size spectratyping were observed among these tumor specimens, but not in normal tissues or PBMCs. In addition, identical peaks were detected in multiple specimens of the same tumor. The ratio of the levels of IFN-γ to that of IL-4 is significantly higher for tumor lesions compared with PBMCs. These results suggested that a limited number of TILs locally expand in response to tumor antigens exiting within gastric or colorectal cancers and local predominant production of the T helper 1/T cytotoxic 1 type cytokine may affect the anti-tumor immune response of TILs.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Evidence for existence of oligoclonal tumor-infiltrating lymphocytes and predominant production of T helper 1/T cytotoxic 1 type cytokines in gastric and colorectal tumors

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