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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2004 Volume 25 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2004 Volume 25 Issue 1

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Article

In vitro quantification of the cytotoxic T lymphocyte response against human telomerase reverse transcriptase in breast cancer

  • Authors:
    • Shoba Maria Prescilla Amarnath
    • Charlotte Emma Dyer
    • Aswatha Ramesh
    • Obi Iwuagwu
    • Philip John Drew
    • John Greenman

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Postgraduate Medical Institute, University of Hull, Hull, UK
  • Pages: 211-217
    |
    Published online on: July 1, 2004
       https://doi.org/10.3892/ijo.25.1.211
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Abstract

Telomerase is expressed in approximately 90% of breast cancers but not in normal somatic cells. The catalytic subunit of telomerase, human telomerase reverse transcriptase (hTERT), is a widely expressed tumour-associated antigen against which specific cytotoxic T lymphocyte (CTL) responses have been identified. Human CD8+ CTL have been shown to recognise hTERT synthetic peptides in an HLA-restricted manner and to lyse hTERT+ tumour cells. This study has investigated the specific CD8+ CTL response in a defined cohort of primary breast cancer patients against 3 hTERT peptides using an IFNγ ELISpot assay. A specific CD8+ CTL response against at least one of the hTERT peptides was observed in 75% of cancer patients, with 8/17 patients responding to both HLA-A2 restricted peptides. In contrast, 38% of normal healthy female controls responded against a single peptide only. This suggests that a specific immune response exists against hTERT in breast cancer patients and that hTERT is a suitable target for tumour-based immunotherapy.

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Copy and paste a formatted citation
Spandidos Publications style
Amarnath SM, Dyer CE, Ramesh A, Iwuagwu O, Drew PJ and Greenman J: In vitro quantification of the cytotoxic T lymphocyte response against human telomerase reverse transcriptase in breast cancer. Int J Oncol 25: 211-217, 2004.
APA
Amarnath, S.M., Dyer, C.E., Ramesh, A., Iwuagwu, O., Drew, P.J., & Greenman, J. (2004). In vitro quantification of the cytotoxic T lymphocyte response against human telomerase reverse transcriptase in breast cancer. International Journal of Oncology, 25, 211-217. https://doi.org/10.3892/ijo.25.1.211
MLA
Amarnath, S. M., Dyer, C. E., Ramesh, A., Iwuagwu, O., Drew, P. J., Greenman, J."In vitro quantification of the cytotoxic T lymphocyte response against human telomerase reverse transcriptase in breast cancer". International Journal of Oncology 25.1 (2004): 211-217.
Chicago
Amarnath, S. M., Dyer, C. E., Ramesh, A., Iwuagwu, O., Drew, P. J., Greenman, J."In vitro quantification of the cytotoxic T lymphocyte response against human telomerase reverse transcriptase in breast cancer". International Journal of Oncology 25, no. 1 (2004): 211-217. https://doi.org/10.3892/ijo.25.1.211
Copy and paste a formatted citation
x
Spandidos Publications style
Amarnath SM, Dyer CE, Ramesh A, Iwuagwu O, Drew PJ and Greenman J: In vitro quantification of the cytotoxic T lymphocyte response against human telomerase reverse transcriptase in breast cancer. Int J Oncol 25: 211-217, 2004.
APA
Amarnath, S.M., Dyer, C.E., Ramesh, A., Iwuagwu, O., Drew, P.J., & Greenman, J. (2004). In vitro quantification of the cytotoxic T lymphocyte response against human telomerase reverse transcriptase in breast cancer. International Journal of Oncology, 25, 211-217. https://doi.org/10.3892/ijo.25.1.211
MLA
Amarnath, S. M., Dyer, C. E., Ramesh, A., Iwuagwu, O., Drew, P. J., Greenman, J."In vitro quantification of the cytotoxic T lymphocyte response against human telomerase reverse transcriptase in breast cancer". International Journal of Oncology 25.1 (2004): 211-217.
Chicago
Amarnath, S. M., Dyer, C. E., Ramesh, A., Iwuagwu, O., Drew, P. J., Greenman, J."In vitro quantification of the cytotoxic T lymphocyte response against human telomerase reverse transcriptase in breast cancer". International Journal of Oncology 25, no. 1 (2004): 211-217. https://doi.org/10.3892/ijo.25.1.211
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