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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 2004 Volume 25 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2004 Volume 25 Issue 2

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Article

Overexpression of CD105 in rat myoblasts: Role of CD105 in cell attachment, spreading and survival

  • Authors:
    • Baoqiang Guo
    • Paul Rooney
    • Mark Slevin
    • Chenggang Li
    • Sudeep Parameshwar
    • Donghui Liu
    • Pat Kumar
    • Carmelo Bernabeu
    • Shant Kumar

  • View Affiliations / Copyright

    Affiliations: Laboratory Medicine Academic Group, The Medical School, University of Manchester, Manchester, M13 9PT, UK. baoqiang.guo@man.ac.uk
  • Pages: 285-291
    |
    Published online on: August 1, 2004
       https://doi.org/10.3892/ijo.25.2.285
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Abstract

CD105 is a receptor for transforming growth factor-β but it is also considered to be involved in cellular functions such as cell adhesion and migration. Using CD105 transfected rat myoblasts, we have investigated the role of CD105 in cell adhesion, spreading, growth and migration. CD105 transfected myoblasts expressed abundant CD105, which was preferentially located within focal adhesion sites. These cells took on a bipolar morphology whereas mock cells remained polygonal or rounded, and when wounded, CD105 expressing cells realigned their long axis prior to migrating and migrated as a cohort of cells. CD105 expression promoted cellular attachment, spreading, survival and growth in serum-free conditions and each of these parameters could be inhibited by a RGD-containing peptide but not a RAD-containing peptide. Mock-transfected cells could not attach, spread or grow under these conditions. Attachment, spreading and growth in CD105 expressing cells could be promoted by the addition of a monoclonal antibody against CD105. Expression of CD105 resulted in the phosphorylation of JNK1 but had no effect on β1 integrin expression. From this preliminary study, we conclude that in addition to acting as a transforming growth factor-β receptor, CD105 has an important role in cell adhesion, migration and survival.

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Copy and paste a formatted citation
Spandidos Publications style
Guo B, Rooney P, Slevin M, Li C, Parameshwar S, Liu D, Kumar P, Bernabeu C and Kumar S: Overexpression of CD105 in rat myoblasts: Role of CD105 in cell attachment, spreading and survival. Int J Oncol 25: 285-291, 2004.
APA
Guo, B., Rooney, P., Slevin, M., Li, C., Parameshwar, S., Liu, D. ... Kumar, S. (2004). Overexpression of CD105 in rat myoblasts: Role of CD105 in cell attachment, spreading and survival. International Journal of Oncology, 25, 285-291. https://doi.org/10.3892/ijo.25.2.285
MLA
Guo, B., Rooney, P., Slevin, M., Li, C., Parameshwar, S., Liu, D., Kumar, P., Bernabeu, C., Kumar, S."Overexpression of CD105 in rat myoblasts: Role of CD105 in cell attachment, spreading and survival". International Journal of Oncology 25.2 (2004): 285-291.
Chicago
Guo, B., Rooney, P., Slevin, M., Li, C., Parameshwar, S., Liu, D., Kumar, P., Bernabeu, C., Kumar, S."Overexpression of CD105 in rat myoblasts: Role of CD105 in cell attachment, spreading and survival". International Journal of Oncology 25, no. 2 (2004): 285-291. https://doi.org/10.3892/ijo.25.2.285
Copy and paste a formatted citation
x
Spandidos Publications style
Guo B, Rooney P, Slevin M, Li C, Parameshwar S, Liu D, Kumar P, Bernabeu C and Kumar S: Overexpression of CD105 in rat myoblasts: Role of CD105 in cell attachment, spreading and survival. Int J Oncol 25: 285-291, 2004.
APA
Guo, B., Rooney, P., Slevin, M., Li, C., Parameshwar, S., Liu, D. ... Kumar, S. (2004). Overexpression of CD105 in rat myoblasts: Role of CD105 in cell attachment, spreading and survival. International Journal of Oncology, 25, 285-291. https://doi.org/10.3892/ijo.25.2.285
MLA
Guo, B., Rooney, P., Slevin, M., Li, C., Parameshwar, S., Liu, D., Kumar, P., Bernabeu, C., Kumar, S."Overexpression of CD105 in rat myoblasts: Role of CD105 in cell attachment, spreading and survival". International Journal of Oncology 25.2 (2004): 285-291.
Chicago
Guo, B., Rooney, P., Slevin, M., Li, C., Parameshwar, S., Liu, D., Kumar, P., Bernabeu, C., Kumar, S."Overexpression of CD105 in rat myoblasts: Role of CD105 in cell attachment, spreading and survival". International Journal of Oncology 25, no. 2 (2004): 285-291. https://doi.org/10.3892/ijo.25.2.285
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