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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 2004 Volume 25 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2004 Volume 25 Issue 3

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Article

Loss of SFRP1 is associated with breast cancer progression and poor prognosis in early stage tumors

  • Authors:
    • Eva Klopocki
    • Glen Kristiansen
    • Peter J. Wild
    • Irina Klaman
    • Esmeralda Castanos-Velez
    • Gad Singer
    • Robert Stöhr
    • Ronald Simon
    • Guido Sauter
    • Haike Leibiger
    • Lutz Essers
    • Birgit Weber
    • Klaus Hermann
    • André Rosenthal
    • Arndt Hartmann
    • Edgar Dahl
  • View Affiliations / Copyright

    Affiliations: Freie Universität Berlin, D-14195 Berlin, Germany
  • Pages: 641-649
    |
    Published online on: September 1, 2004
       https://doi.org/10.3892/ijo.25.3.641
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Abstract

Aberrant activation of the Wnt signaling pathway plays an important role in the development of solid tumors such as breast and colon cancer. Secreted Frizzled-related protein 1 (SFRP1) is a negative regulator of the Wnt pathway. It has been described that SFRP1 mRNA is strongly down-regulated in breast cancer and a putative tumor suppressor function has been postulated. We have generated and characterized an SFRP1 specific antibody to analyze its expression on protein level and to investigate the association of SFRP1 expression with clinicopathological parameters and patient survival. Analysis of >2000 invasive breast tumors and 56 carcinoma in situ revealed similar frequencies of SFRP1 loss in these tumors (46% and 43% respectively). Therefore, we propose that loss of SFRP1 expression is an early event in breast tumorigenesis. SFRP1 expression was inversely correlated with tumor stage (p<0.001) but not with tumor grade (p=0.14) or lymph node status (p=0.84). Performing a multivariate analysis we could confirm the association between tumor stage and SFRP1 expression (p=0.029). In particular, loss of SFRP1 expression in early stage breast tumors (pT1) was associated with poor prognosis (p=0.04). In conclusion, expression of SFRP1 is commonly lost in breast cancer. SFRP1 expression might be useful as a novel prognostic marker in early stage breast cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Klopocki E, Kristiansen G, Wild PJ, Klaman I, Castanos-Velez E, Singer G, Stöhr R, Simon R, Sauter G, Leibiger H, Leibiger H, et al: Loss of SFRP1 is associated with breast cancer progression and poor prognosis in early stage tumors. Int J Oncol 25: 641-649, 2004.
APA
Klopocki, E., Kristiansen, G., Wild, P.J., Klaman, I., Castanos-Velez, E., Singer, G. ... Dahl, E. (2004). Loss of SFRP1 is associated with breast cancer progression and poor prognosis in early stage tumors. International Journal of Oncology, 25, 641-649. https://doi.org/10.3892/ijo.25.3.641
MLA
Klopocki, E., Kristiansen, G., Wild, P. J., Klaman, I., Castanos-Velez, E., Singer, G., Stöhr, R., Simon, R., Sauter, G., Leibiger, H., Essers, L., Weber, B., Hermann, K., Rosenthal, A., Hartmann, A., Dahl, E."Loss of SFRP1 is associated with breast cancer progression and poor prognosis in early stage tumors". International Journal of Oncology 25.3 (2004): 641-649.
Chicago
Klopocki, E., Kristiansen, G., Wild, P. J., Klaman, I., Castanos-Velez, E., Singer, G., Stöhr, R., Simon, R., Sauter, G., Leibiger, H., Essers, L., Weber, B., Hermann, K., Rosenthal, A., Hartmann, A., Dahl, E."Loss of SFRP1 is associated with breast cancer progression and poor prognosis in early stage tumors". International Journal of Oncology 25, no. 3 (2004): 641-649. https://doi.org/10.3892/ijo.25.3.641
Copy and paste a formatted citation
x
Spandidos Publications style
Klopocki E, Kristiansen G, Wild PJ, Klaman I, Castanos-Velez E, Singer G, Stöhr R, Simon R, Sauter G, Leibiger H, Leibiger H, et al: Loss of SFRP1 is associated with breast cancer progression and poor prognosis in early stage tumors. Int J Oncol 25: 641-649, 2004.
APA
Klopocki, E., Kristiansen, G., Wild, P.J., Klaman, I., Castanos-Velez, E., Singer, G. ... Dahl, E. (2004). Loss of SFRP1 is associated with breast cancer progression and poor prognosis in early stage tumors. International Journal of Oncology, 25, 641-649. https://doi.org/10.3892/ijo.25.3.641
MLA
Klopocki, E., Kristiansen, G., Wild, P. J., Klaman, I., Castanos-Velez, E., Singer, G., Stöhr, R., Simon, R., Sauter, G., Leibiger, H., Essers, L., Weber, B., Hermann, K., Rosenthal, A., Hartmann, A., Dahl, E."Loss of SFRP1 is associated with breast cancer progression and poor prognosis in early stage tumors". International Journal of Oncology 25.3 (2004): 641-649.
Chicago
Klopocki, E., Kristiansen, G., Wild, P. J., Klaman, I., Castanos-Velez, E., Singer, G., Stöhr, R., Simon, R., Sauter, G., Leibiger, H., Essers, L., Weber, B., Hermann, K., Rosenthal, A., Hartmann, A., Dahl, E."Loss of SFRP1 is associated with breast cancer progression and poor prognosis in early stage tumors". International Journal of Oncology 25, no. 3 (2004): 641-649. https://doi.org/10.3892/ijo.25.3.641
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