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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 2004 Volume 25 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2004 Volume 25 Issue 3

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Article

Multiple EBNA1-binding sites within oriPI are required for EBNA1-dependent transactivation of the Epstein-Barr virus C promoter

  • Authors:
    • Henrik Zetterberg
    • Cecilia Boreström
    • Tina Nilsson
    • Lars Rymo

  • View Affiliations / Copyright

    Affiliations: Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, S-413 45 Göteborg, Sweden. henrik.zetterberg@clinchem.gu.se
  • Pages: 693-696
    |
    Published online on: September 1, 2004
       https://doi.org/10.3892/ijo.25.3.693
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Abstract

The transactivating function of the oriPI-EBNA1 complex is essential for activation of the Epstein-Barr virus (EBV) C promoter (Cp) in lymphoblastoid cell lines expressing the viral growth programme. Furthermore, the oriPI-EBNA1 complex is believed to play an important role during promoter switching upon primary infection of B-lymphocytes and establishment of latent infection in vivo. Previously, it was shown that six EBNA1-binding sites within oriPI were required for transactivation of the heterologous thymidine kinase promoter. Here, we define the number of EBNA1-binding sites within oriPI necessary for its biological function as EBNA1-dependent Cp enhancer. We show that four EBNA1-binding sites within oriPI lead to significant upregulation of Cp in response to EBNA1 and eight or more to full activation. Thus, multiple EBNA1 homodimers at oriPI are required for the formation of a transcriptionally active Cp complex, a process that involves EBNA1-induced changes in the chromatin structure including DNA looping and nucleosome destabilization.

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Copy and paste a formatted citation
Spandidos Publications style
Zetterberg H, Boreström C, Nilsson T and Rymo L: Multiple EBNA1-binding sites within oriPI are required for EBNA1-dependent transactivation of the Epstein-Barr virus C promoter. Int J Oncol 25: 693-696, 2004.
APA
Zetterberg, H., Boreström, C., Nilsson, T., & Rymo, L. (2004). Multiple EBNA1-binding sites within oriPI are required for EBNA1-dependent transactivation of the Epstein-Barr virus C promoter. International Journal of Oncology, 25, 693-696. https://doi.org/10.3892/ijo.25.3.693
MLA
Zetterberg, H., Boreström, C., Nilsson, T., Rymo, L."Multiple EBNA1-binding sites within oriPI are required for EBNA1-dependent transactivation of the Epstein-Barr virus C promoter". International Journal of Oncology 25.3 (2004): 693-696.
Chicago
Zetterberg, H., Boreström, C., Nilsson, T., Rymo, L."Multiple EBNA1-binding sites within oriPI are required for EBNA1-dependent transactivation of the Epstein-Barr virus C promoter". International Journal of Oncology 25, no. 3 (2004): 693-696. https://doi.org/10.3892/ijo.25.3.693
Copy and paste a formatted citation
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Spandidos Publications style
Zetterberg H, Boreström C, Nilsson T and Rymo L: Multiple EBNA1-binding sites within oriPI are required for EBNA1-dependent transactivation of the Epstein-Barr virus C promoter. Int J Oncol 25: 693-696, 2004.
APA
Zetterberg, H., Boreström, C., Nilsson, T., & Rymo, L. (2004). Multiple EBNA1-binding sites within oriPI are required for EBNA1-dependent transactivation of the Epstein-Barr virus C promoter. International Journal of Oncology, 25, 693-696. https://doi.org/10.3892/ijo.25.3.693
MLA
Zetterberg, H., Boreström, C., Nilsson, T., Rymo, L."Multiple EBNA1-binding sites within oriPI are required for EBNA1-dependent transactivation of the Epstein-Barr virus C promoter". International Journal of Oncology 25.3 (2004): 693-696.
Chicago
Zetterberg, H., Boreström, C., Nilsson, T., Rymo, L."Multiple EBNA1-binding sites within oriPI are required for EBNA1-dependent transactivation of the Epstein-Barr virus C promoter". International Journal of Oncology 25, no. 3 (2004): 693-696. https://doi.org/10.3892/ijo.25.3.693
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