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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2004 Volume 25 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2004 Volume 25 Issue 4

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Article

Enhancement of apoptosis in salivary gland cancer cells by the combination of oral fluoropyrimidine anticancer agent (S-1) and radiation

  • Authors:
    • Koji Harada
    • Shin-Ichi Kawaguchi
    • Supriatno
    • Tomitaro Onoue
    • Hideo Yoshida
    • Mitsunobu Sato

  • View Affiliations / Copyright

    Affiliations: Second Department of Oral and Maxillofacial Surgery, University of Tokushima, School of Dentistry, Tokushima 770-8504, Japan. harako@dent.tokushima-u.ac.jp , Second Department of Oral and Maxillofacial Surgery, University of Tokushima, School of Dentistry, 3-18-15 Kuramoto-cho, Tokushima 770-8504, Japan. harako@dent.tokushima-u.ac.jp
  • Pages: 905-911
    |
    Published online on: October 1, 2004
       https://doi.org/10.3892/ijo.25.4.905
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Abstract

S-1 is a new oral antineoplastic agent which can inhibit cell growth and induces apoptosis in certain types of cancer cells including gastric carcinomas, colorectal cancers and salivary gland cancers, but its effect on response of tumor cells to radiation has not been clarified yet. We have reported that S-1 can sensitize human oral cancer cells to radiation, and that S-1 in combination with radiation can exert remarkable effects on decreasing clonogenic survival and in vivo tumor growth. Here, we demonstrate the mechanism of apoptosis enhancing activity by the combination treatment of S-1 and radiation in salivary gland cancer cells. S-1 in combination with radiation have a remarkable effect on decreasing in vitro cell growth. In addition, the combined treatment of S-1 and radiation resulted in an increased DNA fragmentation by detecting Hoechst 33258 staining. Moreover, apoptosis of the cells by combined treatment of S-1 and radiation was associated with reactive oxygen/nitrogen species generation and the activation of caspase-8, -9 and -3. These results indicate that S-1 in combination with radiation can markedly enhance apoptosis of salivary gland cancer cells, and the combined therapy of S-1 and radiation are currently leading to the design of clinical studies.

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Copy and paste a formatted citation
Spandidos Publications style
Harada K, Kawaguchi S, Supriatno , Onoue T, Yoshida H and Sato M: Enhancement of apoptosis in salivary gland cancer cells by the combination of oral fluoropyrimidine anticancer agent (S-1) and radiation. Int J Oncol 25: 905-911, 2004.
APA
Harada, K., Kawaguchi, S., Supriatno, , Onoue, T., Yoshida, H., & Sato, M. (2004). Enhancement of apoptosis in salivary gland cancer cells by the combination of oral fluoropyrimidine anticancer agent (S-1) and radiation. International Journal of Oncology, 25, 905-911. https://doi.org/10.3892/ijo.25.4.905
MLA
Harada, K., Kawaguchi, S., Supriatno, , Onoue, T., Yoshida, H., Sato, M."Enhancement of apoptosis in salivary gland cancer cells by the combination of oral fluoropyrimidine anticancer agent (S-1) and radiation". International Journal of Oncology 25.4 (2004): 905-911.
Chicago
Harada, K., Kawaguchi, S., Supriatno, , Onoue, T., Yoshida, H., Sato, M."Enhancement of apoptosis in salivary gland cancer cells by the combination of oral fluoropyrimidine anticancer agent (S-1) and radiation". International Journal of Oncology 25, no. 4 (2004): 905-911. https://doi.org/10.3892/ijo.25.4.905
Copy and paste a formatted citation
x
Spandidos Publications style
Harada K, Kawaguchi S, Supriatno , Onoue T, Yoshida H and Sato M: Enhancement of apoptosis in salivary gland cancer cells by the combination of oral fluoropyrimidine anticancer agent (S-1) and radiation. Int J Oncol 25: 905-911, 2004.
APA
Harada, K., Kawaguchi, S., Supriatno, , Onoue, T., Yoshida, H., & Sato, M. (2004). Enhancement of apoptosis in salivary gland cancer cells by the combination of oral fluoropyrimidine anticancer agent (S-1) and radiation. International Journal of Oncology, 25, 905-911. https://doi.org/10.3892/ijo.25.4.905
MLA
Harada, K., Kawaguchi, S., Supriatno, , Onoue, T., Yoshida, H., Sato, M."Enhancement of apoptosis in salivary gland cancer cells by the combination of oral fluoropyrimidine anticancer agent (S-1) and radiation". International Journal of Oncology 25.4 (2004): 905-911.
Chicago
Harada, K., Kawaguchi, S., Supriatno, , Onoue, T., Yoshida, H., Sato, M."Enhancement of apoptosis in salivary gland cancer cells by the combination of oral fluoropyrimidine anticancer agent (S-1) and radiation". International Journal of Oncology 25, no. 4 (2004): 905-911. https://doi.org/10.3892/ijo.25.4.905
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