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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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International Journal of Oncology

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
October 2004 Volume 25 Issue 4

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Journal Metrics

Impact Factor: 4.9

CiteScore: 8.9

CiteScore Rank: Q1: #66/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Article

Genome-wide gene-expression profiles of breast-cancer cells purified with laser microbeam microdissection: Identification of genes associated with progression and metastasis

Toshihiko Nishidate, Toyomasa Katagiri, Meng-Lay Lin, Yuria Mano, Yoshio Miki, Fujio Kasumi, Masataka Yoshimoto, Tatsuhiko Tsunoda, Koichi Hirata, Yusuke Nakamura
Pages: 797-819
Published online on: 01 October 2004

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Article

Deregulated expression of the PCPH proto-oncogene in human breast cancers

Maria José Blánquez, Maria Isabel Arenas, Isabel Conde, Oscar M. Tirado, Ricardo Paniagua, Vicente Notario
Pages: 821-830
Published online on: 01 October 2004

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Article

Overexpression of c-met in oral SCC promotes hepatocyte growth factor-induced disruption of cadherin junctions and invasion

M. Murai, X. Shen, L. Huang, W. M. Carpenter, C. S. Lin, S. Silverman, J. Regezi, R. H. Kramer
Pages: 831-840
Published online on: 01 October 2004

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Article

Opsonization with a trifunctional bispecific (αCD3 x αEpCAM) antibody results in efficient lysis in vitro and in vivo of EpCAM positive tumor cells by cytotoxic T lymphocytes

M. Schmitt, A. Schmitt, P. Reinhardt, B. Thess, B. Manfras, H. Lindhofer, H. Riechelmann, M. Wiesneth, S. Gronau
Pages: 841-848
Published online on: 01 October 2004

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Article

Angiotensin II activates MAP kinase and NF-κB through angiotensin II type I receptor in human pancreatic cancer cells

Koji Amaya, Tetsuo Ohta, Hirohisa Kitagawa, Masato Kayahara, Hiroyuki Takamura, Takashi Fujimura, Gen-Ichi Nishimura, Koichi Shimizu, Koichi Miwa
Pages: 849-856
Published online on: 01 October 2004

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Article

Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism

Hala Gali-Muhtasib, Mona Diab-Assaf, Carsten Boltze, Josianne Al-Hmaira, Roland Hartig, Albert Roessner, Regine Schneider-Stock
Pages: 857-866
Published online on: 01 October 2004

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Article

Bone marrow microenvironment facilitating dendritic cell: CD4 T cell interactions and maintenance of CD4 memory

Markus Feuerer, Philipp Beckhove, Yolanda Mahnke, Mirja Hommel, Bruno Kyewski, Alf Hamann, Viktor Umansky, Volker Schirrmacher
Pages: 867-876
Published online on: 01 October 2004

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Article

Thymidylate synthase expression pattern is a prognostic factor in patients of colorectal cancer treated with 5-fluorouracil

María-Encarnación Fernández-Contreras, Beatriz Jiménez de Ayala, María-Luisa García de Paredes, Amalia Velasco, Pedro L. Majano, José Palacios, Carlos Gamallo
Pages: 877-885
Published online on: 01 October 2004

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Article

Photodynamic-induced vascular damage of the chick chorioallantoic membrane model using perylenequinones

William Chin, Weber Lau, Saw Lay Lay, Kho Kiang Wei, Malini Olivo
Pages: 887-891
Published online on: 01 October 2004

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Article

Multicolor FISH and cytometric analyses allow classification of urothelial carcinomas into two subtypes, low- and high-grade tumors

Kenzo Ikemoto, Tomoko Furuya, Kenji Matsuda, Shigeto Kawauchi, Atsunori Oga, Junko Ikeda, Xiu Ping Liu, Kohsuke Sasaki
Pages: 893-898
Published online on: 01 October 2004

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Article

Evidence of oxytocin/oxytocin receptor interplay in human prostate gland and carcinomas

Paola Cassoni, Tiziana Marrocco, Anna Sapino, Elena Allia, Gianni Bussolati
Pages: 899-904
Published online on: 01 October 2004

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Article

Enhancement of apoptosis in salivary gland cancer cells by the combination of oral fluoropyrimidine anticancer agent (S-1) and radiation

Koji Harada, Shin-Ichi Kawaguchi, Supriatno, Tomitaro Onoue, Hideo Yoshida, Mitsunobu Sato
Pages: 905-911
Published online on: 01 October 2004

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Article

Dysfunction of p53 pathway in human colorectal cancer: analysis of p53 gene mutation and the expression of the p53-associated factors p14ARF, p33ING1, p21WAF1 and MDM2.

Masatsugu Tachibana, Hitoshi Kawamata, Takahiro Fujimori, Fumie Omotehara, Hideki Horiuchi, Yasuo Ohkura, Seiji Igarashi, Kenjiro Kotake, Keiichi Kubota
Pages: 913-933
Published online on: 01 October 2004

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Article

NAD(P)H:Quinone oxidoreductase-1 C609T polymorphism analysis in human superficial bladder cancers: relationship of genotype status to NQO1 phenotype and clinical response to Mitomycin C.

Saurajyoti Basu, John E Brown, G Michael Flannigan, Jason H Gill, Paul M Loadman, Sandie W Martin, Brian Naylor, Rajiv Puri, Andrew J Scally, Jill M Seargent, Tariq Shah, Roger M Phillips
Pages: 921-928
Published online on: 01 October 2004

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Article

Comparison of automated and manual determination of HER2 status in breast cancer for diagnostic use: a comparative methodological study using the Ventana BenchMark automated staining system and manual tests.

Agnes Bánkfalvi, Werner Boecker, Angelika Reiner
Pages: 929-964
Published online on: 01 October 2004

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Article

Sialylated core 1 based O-linked glycans enhance the growth rate of mammary carcinoma cells in MUC1 transgenic mice.

Arron Mungul, Lucienne Cooper, Inka Brockhausen, Kenneth Ryder, Ulla Mandel, Henrik Clausen, Aurelia Rughetti, David W Miles, Joyce Taylor-Papadimitriou, Joy M Burchell
Pages: 937-980
Published online on: 01 October 2004

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Article

Cytosolic thymidine kinase is a specific histopathologic tumour marker for breast carcinomas.

Qimin He, Yongrong Mao, Jainping Wu, Catrine Decker, Malik Merza, Naining Wang, Staffan Eriksson, Juan Castro, Sven Skog
Pages: 945-998
Published online on: 01 October 2004

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Article

Molecular cytogenetic characterization shows higher genetic homogeneity in conventional renal cell carcinoma compared to other kidney cancers.

Andrei Alimov, Birgitta Sundelin, Ulf Bergerheim, Maxim Pavlenko, Pavel Pisa, Anders Zetterberg, Catharina Larsson, Svetlana Lagercrantz
Pages: 955-1015
Published online on: 01 October 2004

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Article

Breast cancer progression in MCF10A series of cell lines is associated with alterations in retinoic acid and retinoid X receptors and with differential response to retinoids.

Xinjian Peng, Duri Yun, Konstantin Christov
Pages: 961-1032
Published online on: 01 October 2004

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Article

Cancer evolution and immunity in a rat colorectal carcinogenesis model.

Luca Vannucci, Anna Fiserova, Ondrej Horvath, Pavel Rossmann, Franco Mosca, Miloslav Pospisil
Pages: 973-1054
Published online on: 01 October 2004

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Article

Galectin-3 and cancer (Review).

Stéphane Califice, Vincent Castronovo, Frédéric Van Den Brûle
Pages: 983-1075
Published online on: 01 October 2004

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Article

A novel C/T polymorphism in the core promoter of human de novo cytosine DNA methyltransferase 3B6 is associated with prognosis in head and neck cancer.

Luo Wang, Marivonne Rodriguez, Edward S Kim, Yunling Xu, Neby Bekele, Adel K El-Naggar, Waun Ki Hong, Li Mao, Yun W Oh
Pages: 993-1002
Published online on: 01 October 2004

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Article

Influence of keratinocyte growth factor on clonal growth of epithelial tumor cells, lymphoma and leukemia cells and on sensitivity of tumor cells towards 5-fluorouracil in vitro.

Elisabeth Oelmann, Susan Haghgu, Emma Kulimova, Rolf M Mesters, Joachim Kienast, Hermann Herbst, Christiane Schmitmann, Astrid Kolkmeyer, Hubert Serve, Wolfgang E Berdel
Pages: 1001-1013
Published online on: 01 October 2004

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Article

CRIPTO-1: a novel target for therapeutic intervention in human carcinoma.

Nicola Normanno, Antonella De Luca, Monica R Maiello, Caterina Bianco, Mario Mancino, Luigi Strizzi, Claudio Arra, Fortunato Ciardiello, Sudhir Agrawal, David S Salomon
Pages: 1013-1033
Published online on: 01 October 2004

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Article

Impact of dehydroepiandrosterone on hepatocarcinogenesis in the rat (Review).

Doris Mayer, Klaus Forstner
Pages: 1021-1051
Published online on: 01 October 2004

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Article

Transcription factor NF-Y regulates mdr1 expression through binding to inverted CCAAT sequence in drug-resistant human squamous carcinoma cells.

Hirohiko Okamura, Kaya Yoshida, Eiko Sasaki, Hiroyuki Morimoto, Tatsuji Haneji
Pages: 1031-1038
Published online on: 01 October 2004

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Article

Polyploidisation of metastatic colon carcinoma cells by microtubule and tubulin interacting drugs: effect on proteolytic activity and invasiveness.

Nikolaus Seiler, Yann Schneider, Francine Gossé, René Schleiffer, Francis Raul
Pages: 1039-1087
Published online on: 01 October 2004

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Article

Search for epithelial-specific mRNAs in peripheral blood of patients with colon cancer by RT-PCR.

Rossella Solmi, Paola De Sanctis, Cinzia Zucchini, Giampaolo Ugolini, Giancarlo Rosati, Marco Del Governatore, Domenico Coppola, Thymothy J Yeatman, Luca Lenzi, Antonello Caira, Simone Zanotti, Mario Taffurelli, Paolo Carinci, Luisa Valvassori, Pierluigi Strippoli
Pages: 1049-1105
Published online on: 01 October 2004

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Article

A telomerase-immortalized primary human prostate cancer clonal cell line with neoplastic phenotypes.

Yongpeng Gu, Kee-Hong Kim, Daejin Ko, Keiichiro Nakamura, Yutaka Yasunaga, Judd W Moul, Shiv Srivastava, Paul Arnstein, Johng S Rhim
Pages: 1057-1121
Published online on: 01 October 2004

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Article

siRNA-mediated down-regulation of survivin inhibits bladder cancer cell growth.

Shuangli Ning, Susanne Fuessel, Matthias Kotzsch, Kai Kraemer, Matthias Kappler, Uta Schmidt, Helge Taubert, Manfred P Wirth, Axel Meye
Pages: 1065-1136
Published online on: 01 October 2004

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Article

Evidence for transcriptional repression of SPARC-like 1, a gene downregulated in human lung tumors.

Silvia G Isler, Christian U Ludwig, Ruth Chiquet-Ehrismann, Susanne Schenk
Pages: 1073-1082
Published online on: 01 October 2004

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Article

Modulation of the transactivation function of nuclear factor-kappaB by lipopolysaccharide in RAW264.7 macrophages.

Sang Won Jung, Mi Hee Lee, Yong Chan Kim, Sang-Gi Paik, Yung Hyun Choi, Young Sang Kim, Kwang Il Kang
Pages: 1081-1088
Published online on: 01 October 2004

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Article

Enhanced expression of adaptor molecule p46 Shc in nuclei of hepatocellular carcinoma cells: study of LEC rats.

Shuhei Yoshida, Tsutomu Masaki, Han Feng, Jin Yuji, Yoshiaki Miyauchi, Toshiharu Funaki, Hitoshi Yoshiji, Kouzo Matsumoto, Naohito Uchida, Seishiro Watanabe, Kazutaka Kurokohchi, Shigeki Kuriyama
Pages: 1089-1185
Published online on: 01 October 2004

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Article

A novel 4,4'-bispyridyl-5,5'-perfluoroalkyl-2,2'-bisoxazol with antitumoral activity via cell cycle arrest and induction of apoptosis.

Mónica Báñez-Coronel, Agustín Rodríguez-González, Yolanda Martín-Cantalejo, Beatriz Sáez, Javier Soto, M Jesús Villa, Miguel F Braña, Juan Carlos Lacal
Pages: 1097-1200
Published online on: 01 October 2004

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Article

Confirmation of 42-bp deletion within the ERCC1 5' UTR.

Tiyuan Li, Yuping Song, Xiaobing Liang, Ying Guo, Eddie Reed, Jing Jie Yu
Pages: 1105-1116
Published online on: 01 October 2004

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Article

Construction and expression of a bispecific single-chain antibody that penetrates mutant p53 colon cancer cells and binds p53.

Richard H Weisbart, Rika Wakelin, Grace Chan, Carl W Miller, Phillip H Koeffler
Pages: 1113-1121
Published online on: 01 October 2004

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Article

Expression of the cell surface mucin gene family in adenocarcinomas.

Leisl M Packer, Stephanie J Williams, Shirley Callaghan, David C Gotley, Michael A McGuckin
Pages: 1119-1126
Published online on: 01 October 2004

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Article

Risk factors in alcohol associated breast cancer: alcohol dehydrogenase polymorphism and estrogens.

C Coutelle, B Höhn, M Benesova, C M Oneta, P Quattrochi, H-J Roth, H Schmidt-Gayk, A Schneeweiss, G Bastert, H K Seitz
Pages: 1127-1159
Published online on: 01 October 2004

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Article

Prostate cancer chemoprevention: models, limitations and potential (Review).

Sanjay Gupta
Pages: 1133-1181
Published online on: 01 October 2004

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Article

p53 autoantibodies from patients with colorectal cancer recognize common epitopes in the N- or C-terminus of p53.

Jumana Saleh, Dorit Kreissler-Haag, Mathias Montenarh
Pages: 1149-1204
Published online on: 01 October 2004

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Article

Regulation of beta1 integrin expression by PKCepsilon in renal cancer cells.

Walburgis Brenner, Frank Benzing, Justine Gudejko-Thiel, Renate Fischer, Gloria Färber, Jan G Hengstler, Barbara Seliger, Joachim W Thüroff
Pages: 1157-1220
Published online on: 01 October 2004

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Article

HPV16-associated tumours: therapy of surgical minimal residual disease with dendritic cell-based vaccines.

Milan Reinis, Marie Indrová, Luis Mendoza, Romana Mikysková, Jana Bieblová, Jan Bubeník, Jana Símová
Pages: 1165-1235
Published online on: 01 October 2004

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Article

Apoptotic responsiveness of PC-3 prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand: evidence for differential effects of Bcl-xL and Bcl-2 down-regulation.

Jürgen Sonnemann, Volker Gekeler, Antje Sagrauske, Cornelia Müller, Hans-Peter Hofmann, James F Beck
Pages: 1171-1252
Published online on: 01 October 2004

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Article

Expression of vitamin D3 receptor and retinoid receptors in human breast cancer: identification of potential heterodimeric receptors.

I Conde, R Paniagua, B Fraile, A Ruiz, M I Arenas
Pages: 1183-1274
Published online on: 01 October 2004

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Article

Identification and characterization of human CXXC10 gene in silico.

Masuko Katoh, Masaru Katoh
Pages: 1193-1202
Published online on: 01 October 2004

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Article

Characterization of human ARHGAP10 gene in silico.

Masuko Katoh, Masaru Katoh
Pages: 1201-1207
Published online on: 01 October 2004

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Journal Cover
January-2026 Volume 68 Issue 1

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Journal Metrics

Impact Factor: 4.9

CiteScore: 8.9

CiteScore Rank: Q1: #66/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Article Open Access

c‑Myc‑regulated RPLP0 via the ROS‑mediated JAK2/STAT3 positive feedback loop facilitates hepatocellular carcinoma malignancy progression

Yanqiu Meng, Lebin Yuan, Gangrui Meng, Hongxiang Huang, Xianbin Huang, Xinping Xu, Xiaodong Peng
Article Number: 13
Published online on: 27 November 2025

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Review Open Access

Obesity, chronic breast inflammation and carcinogenesis: Molecular pathways and clinical implications (Review)

Fangying Li, Zhenhua Gao
Article Number: 12
Published online on: 27 November 2025

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Review Open Access

The tumor microenvironment in lung cancer: Heterogeneity, therapeutic resistance and emerging treatment strategies (Review)

Li Liu, Li Yang, Hongmin Li, Tianlu Shang, Lihan Liu
Article Number: 11
Published online on: 26 November 2025

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Article Open Access

Discovery of the late autophagy inhibitor FZU‑0045‑053 and its anti‑breast cancer and immunomodulatory effects

Jinlan Luo, Yi Yang, Lulu Cheng, Fangting Cheng, Huangwenlong Zhuang, Shanshan Chen, Panpan Qiao, Yinbin Liang, Li Chen, Yang Sun, Haijun Chen, Qinying Liu
Article Number: 10
Published online on: 26 November 2025

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Correction Open Access

[Corrigendum] RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling

Zi-Hao Qi, Hua-Xiang Xu, Shi-Rong Zhang, Jin-Zhi Xu, Shuo Li, He-Li Gao, Wei Jin, Wen-Quan Wang, Chun-Tao Wu, Quan-Xing Ni, Xian-Jun Yu, Liang Liu
Article Number: 9
Published online on: 24 November 2025

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Article Open Access

Ephrin‑B2 promotes gastric cancer growth by inhibiting apoptosis and regulating the cell cycle via the Wnt/β‑catenin signaling pathway

Ding Ding, Xiaoshan Wang, Ran Xuan, Rui Li, Yalu Zhang, Zhengguang Wang
Article Number: 8
Published online on: 18 November 2025

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Expression of Concern Open Access

[Expression of Concern] Gene therapy for human colorectal cancer cell lines with recombinant adenovirus 5 based on loss of the insulin‑like growth factor 2 imprinting

Huiling Sun, Yuqin Pan, Bangshun He, Qiwen Deng, Rui Li, Yeqiong Xu, Jie Chen, Tianyi Gao, Houqun Ying, Feng Wang, Xian Liu, Shukui Wang
Article Number: 7
Published online on: 18 November 2025

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Review Open Access

Ferroptosis in biliary tract cancer: Molecular mechanisms and therapeutic applications (Review)

Ruiqi Zou, Yushi Dai, Siqi Yang, Haijie Hu, Fuyu Li, Fei Liu
Article Number: 6
Published online on: 14 November 2025

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Expression of Concern Open Access

[Expression of Concern] Radiosensitization of esophageal carcinoma cells by knockdown of RNF2 expression

Xing-Xiao Yang, Ming Ma, Mei-Xiang Sang, Xue-Xiao Wang, Heng Song, Zhi-Kun Liu, Shu-Chai Zhu
Article Number: 5
Published online on: 10 November 2025

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Review Open Access

Targeting ferroptosis in Helicobacter pylori‑associated gastric cancer development: From molecular mechanisms to application prospects (Review)

Chen-Yi Wang, Meng-Hui Wang, Chuan Xie
Article Number: 4
Published online on: 05 November 2025

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Expression of Concern Open Access

[Expression of Concern] Leptin promotes breast cancer cell migration and invasion via IL‑18 expression and secretion

Kuangfa Li, Lan Wei, Yunxiu Huang, Yang Wu, Min Su, Xueli Pang, Nian Wang, Feihu Ji, Changli Zhong, Tingmei Chen
Article Number: 3
Published online on: 04 November 2025

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Review Open Access

Cancer immunotherapy strategies based on transition‑metal medical materials: Still a long way to go (Review)

Zhefei Du, Zhenyu Cao, Chao Fang, Daihan Xie, Lixin Xie, Chunxia Su, Yu Huo
Article Number: 2
Published online on: 04 November 2025

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Expression of Concern Open Access

[Expression of Concern] Regulation of NADPH oxidase (Nox2) by lipid rafts in breast carcinoma cells

Rama Rao Malla, Hari Raghu, Jasti S. Rao
Article Number: 1
Published online on: 23 October 2025

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February-2026 Volume 68 Issue 2

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Journal Metrics

Impact Factor: 4.9

CiteScore: 8.9

CiteScore Rank: Q1: #66/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Retraction Open Access

[Retracted] Cdc42 expression in cervical cancer and its effects on cervical tumor invasion and migration

Hongnan Ye, Youyi Zhang, Li Geng, Zijian Li
Article Number: 20
Published online on: 05 December 2025

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Article Open Access

Regulation and reversal of paclitaxel resistance via the STAT1‑mediated apoptotic pathway in ovarian cancer

Fanchen Wang, Xiaolin Xu, Bin Guan, Xin Li, Jia Yuan, Wencai Guan, Junyu Chen, Jingyi Fang, Qi Lu, Guoxiong Xu
Article Number: 19
Published online on: 05 December 2025

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Review

Cancer stem cell heterogeneity‑inspired therapeutics for enhancing tumor treatment outcomes (Review)

Hanning Xu, Qunchao Si, Yongyao Song, Shengping Sun, Xianghong Wei, Hui Long, Xiaomei Wang
Article Number: 18
Published online on: 04 December 2025

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Review Open Access

Roles of interleukins in spasmolytic polypeptide‑expressing metaplasia (Review)

Jiale Ma, Tiancheng Zhan, Xinyuan Zhang, Wang Gao, Shuangmei Zhao, Huizhen Li
Article Number: 17
Published online on: 03 December 2025

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Expression of Concern Open Access

[Expression of Concern] MUC1 is a downstream target of STAT3 and regulates lung cancer cell survival and invasion

Jingchun Gao, Matthew J. Mcconnell, Bin Yu, Jiannong Li, Justin M. Balko, Esther P. Black, Joseph O. Johnson, Mark C. Lloyd, Soner Altiok, Eric B. Haura
Article Number: 16
Published online on: 03 December 2025

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Review Open Access

Emerging biomarkers in prostate cancer diagnosis and treatment: Insights into genetic, RNA and metabolic markers (Review)

Yuanshe Huang, Jingxin Mao, Xiaobing Li
Article Number: 15
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] GDC‑0152 attenuates the malignant progression of osteosarcoma promoted by ANGPTL2 via PI3K/AKT but not p38MAPK signaling pathway

Lin Yang, Taipengfei Shu, Yingjian Liang, Wenguang Gu, Chunlei Wang, Xuanhe Song, Changdong Fan, Wenbo Wang
Article Number: 14
Published online on: 01 December 2025

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