Detection of S100B, S100A6 and galectin-3 ligands in meningiomas as markers of aggressiveness

  • Authors:
    • Sabine Hancq
    • Isabelle Salmon
    • Jacques Brotchi
    • Hans-Joachim Gabius
    • Claus W. Heizmann
    • Robert Kiss
    • Christine Decaestecker
  • View Affiliations

  • Published online on: November 1, 2004     https://doi.org/10.3892/ijo.25.5.1233
  • Pages: 1233-1240
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Abstract

The biological factors responsible for the increased aggressiveness in atypical meningiomas are not well known. The aim of this study is to evaluate the discriminatory value of a number of biological markers (S100 proteins and galectin-3 and its ligand profile) with respect to benign and atypical meningiomas. Using 63 meningiomas (39 benign and 24 atypical), we performed a semi-quantitative histochemical analysis of both the expression of galectin-3 and its ligand profile and the Ca2+-binding proteins S100A5, S100A6 and S100B. Three features were considered for each marker, namely the labeling index (LI), the staining intensity (SI) and the global score (LI + SI). A low S100A6 labeling index was observed in 51% of the benign and 25% of the atypical meningiomas (P=0.035). Furthermore, high S100B scores were observed in 46% of the benign and in only 8% of the atypical meningiomas (P=0.001). Seventy-one percent of the atypical meningiomas exhibited a low level of staining intensity for the galectin-3-binding sites as compared to only 36% of the benign meningiomas (P=0.007). The combination of these three markers (by means of a decision tree) enabled an improved discriminatory criterion to be established between the benign and the atypical meningiomas. Our results thus suggest that the galectin-3-binding sites and S100B (and S100A6 to a lesser extent) could play a role in the aggressiveness characterizing atypical meningiomas.

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November 2004
Volume 25 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Hancq S, Salmon I, Brotchi J, Gabius H, Heizmann CW, Kiss R and Decaestecker C: Detection of S100B, S100A6 and galectin-3 ligands in meningiomas as markers of aggressiveness. Int J Oncol 25: 1233-1240, 2004.
APA
Hancq, S., Salmon, I., Brotchi, J., Gabius, H., Heizmann, C.W., Kiss, R., & Decaestecker, C. (2004). Detection of S100B, S100A6 and galectin-3 ligands in meningiomas as markers of aggressiveness. International Journal of Oncology, 25, 1233-1240. https://doi.org/10.3892/ijo.25.5.1233
MLA
Hancq, S., Salmon, I., Brotchi, J., Gabius, H., Heizmann, C. W., Kiss, R., Decaestecker, C."Detection of S100B, S100A6 and galectin-3 ligands in meningiomas as markers of aggressiveness". International Journal of Oncology 25.5 (2004): 1233-1240.
Chicago
Hancq, S., Salmon, I., Brotchi, J., Gabius, H., Heizmann, C. W., Kiss, R., Decaestecker, C."Detection of S100B, S100A6 and galectin-3 ligands in meningiomas as markers of aggressiveness". International Journal of Oncology 25, no. 5 (2004): 1233-1240. https://doi.org/10.3892/ijo.25.5.1233