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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2004 Volume 25 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2004 Volume 25 Issue 5

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Article

The PDZ protein Tip-1 is a gain of function target of the HPV16 E6 oncoprotein

  • Authors:
    • Lynne Hampson
    • Chenggang Li
    • Anthony William Oliver
    • Henry Charles Kitchener
    • Ian Noel Hampson

  • View Affiliations / Copyright

    Affiliations: University of Manchester Gynaecological Oncology Laboratory, St Mary's Hospital, Whitworth Park, Manchester M13 OJH, UK
  • Pages: 1249-1256
    |
    Published online on: November 1, 2004
       https://doi.org/10.3892/ijo.25.5.1249
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Abstract

Previous work has indicated that the PDZ domain Tax interacting protein 1 (Tip-1) is a target of the HTLV1 Tax protein and is a potential RhoA effector. We have used the yeast two-hybrid system to show that Tip-1 also interacts with the HPV16 E6 protein. This interaction was confirmed by co-immunoprecipitation from E6 expressing C33A cervical carcinoma cells (C33A-E6) which showed that Tip-1 was not degraded by interaction with the HPV16 E6 oncoprotein. During routine passage we observed that C33A-E6 had a less compact morphology and were less adherent than control vector transfected cells C33A-V cells - a known effect of GTP-RhoA. Comparison of C33A-E6 to C33A-V demonstrated that E6 expressing cells had higher levels of phosphorylated myosin light chains (MLC) and increased cell motility, which was inhibited by antisense silencing of Tip-1 expression and by the RhoA kinase (ROCK) inhibitor Y27632. Both C33A-E6 and C33A-V cells were shown to express GTP activated RhoA. Since ROCKs can be activated by GTP RhoA these data indicate that E6 may increase cell motility by augmenting GTP RhoA mediated activation of ROCKs and that this is dependent on the expression of the Tip-1 protein.

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Copy and paste a formatted citation
Spandidos Publications style
Hampson L, Li C, Oliver AW, Kitchener HC and Hampson IN: The PDZ protein Tip-1 is a gain of function target of the HPV16 E6 oncoprotein. Int J Oncol 25: 1249-1256, 2004.
APA
Hampson, L., Li, C., Oliver, A.W., Kitchener, H.C., & Hampson, I.N. (2004). The PDZ protein Tip-1 is a gain of function target of the HPV16 E6 oncoprotein. International Journal of Oncology, 25, 1249-1256. https://doi.org/10.3892/ijo.25.5.1249
MLA
Hampson, L., Li, C., Oliver, A. W., Kitchener, H. C., Hampson, I. N."The PDZ protein Tip-1 is a gain of function target of the HPV16 E6 oncoprotein". International Journal of Oncology 25.5 (2004): 1249-1256.
Chicago
Hampson, L., Li, C., Oliver, A. W., Kitchener, H. C., Hampson, I. N."The PDZ protein Tip-1 is a gain of function target of the HPV16 E6 oncoprotein". International Journal of Oncology 25, no. 5 (2004): 1249-1256. https://doi.org/10.3892/ijo.25.5.1249
Copy and paste a formatted citation
x
Spandidos Publications style
Hampson L, Li C, Oliver AW, Kitchener HC and Hampson IN: The PDZ protein Tip-1 is a gain of function target of the HPV16 E6 oncoprotein. Int J Oncol 25: 1249-1256, 2004.
APA
Hampson, L., Li, C., Oliver, A.W., Kitchener, H.C., & Hampson, I.N. (2004). The PDZ protein Tip-1 is a gain of function target of the HPV16 E6 oncoprotein. International Journal of Oncology, 25, 1249-1256. https://doi.org/10.3892/ijo.25.5.1249
MLA
Hampson, L., Li, C., Oliver, A. W., Kitchener, H. C., Hampson, I. N."The PDZ protein Tip-1 is a gain of function target of the HPV16 E6 oncoprotein". International Journal of Oncology 25.5 (2004): 1249-1256.
Chicago
Hampson, L., Li, C., Oliver, A. W., Kitchener, H. C., Hampson, I. N."The PDZ protein Tip-1 is a gain of function target of the HPV16 E6 oncoprotein". International Journal of Oncology 25, no. 5 (2004): 1249-1256. https://doi.org/10.3892/ijo.25.5.1249
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