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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2004 Volume 25 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2004 Volume 25 Issue 5

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Article

CD80 gene therapy for lymph node involvement by gastric carcinoma

  • Authors:
    • Kinshi Kosaka
    • Masakazu Yashiro
    • Yoji Sakate
    • Hiroaki Tanaka
    • Takeshi Sunami
    • Masaichi Ohira
    • Kosei Hirakawa
  • View Affiliations / Copyright

    Affiliations: Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka 545-8585, Japan
  • Pages: 1319-1325
    |
    Published online on: November 1, 2004
       https://doi.org/10.3892/ijo.25.5.1319
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Abstract

The co-stimulatory molecule, CD80 (B7-1), is a ligand of CD28 and plays a key role in the induction of cell-mediated immune responses. Many tumors, including gastric cancer, have decreased expression of CD80 which leads to a failure of immune recognition. Lymph node spread is a factor of poor prognosis in gastric cancer. In this study, we transfected the CD80 gene by an adenovirus vector into a human gastric cancer cell line, OCUM-2MLN, and analyzed the effect on lymph node disease in vitro and in vivo. After transfection of CD80 in vitro, the adhesive ability of cancer cells for peripheral blood mononuclear cells and their cytotoxicity showed significant regression (p<0.01). Intratumoral injection of AdCD80 caused significantly growth of subcutaneous tumors. In vivo lymph node spread was suppressed by injection of AdCD80 into gastric tumors. Histopathologic findings revealed CD80-positive cells around the tumor. These results suggest that CD80 gene transfer into cancer cells using an adenovirus vector might be a promising approach for in vivo cancer therapy.

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Copy and paste a formatted citation
Spandidos Publications style
Kosaka K, Yashiro M, Sakate Y, Tanaka H, Sunami T, Ohira M and Hirakawa K: CD80 gene therapy for lymph node involvement by gastric carcinoma. Int J Oncol 25: 1319-1325, 2004.
APA
Kosaka, K., Yashiro, M., Sakate, Y., Tanaka, H., Sunami, T., Ohira, M., & Hirakawa, K. (2004). CD80 gene therapy for lymph node involvement by gastric carcinoma. International Journal of Oncology, 25, 1319-1325. https://doi.org/10.3892/ijo.25.5.1319
MLA
Kosaka, K., Yashiro, M., Sakate, Y., Tanaka, H., Sunami, T., Ohira, M., Hirakawa, K."CD80 gene therapy for lymph node involvement by gastric carcinoma". International Journal of Oncology 25.5 (2004): 1319-1325.
Chicago
Kosaka, K., Yashiro, M., Sakate, Y., Tanaka, H., Sunami, T., Ohira, M., Hirakawa, K."CD80 gene therapy for lymph node involvement by gastric carcinoma". International Journal of Oncology 25, no. 5 (2004): 1319-1325. https://doi.org/10.3892/ijo.25.5.1319
Copy and paste a formatted citation
x
Spandidos Publications style
Kosaka K, Yashiro M, Sakate Y, Tanaka H, Sunami T, Ohira M and Hirakawa K: CD80 gene therapy for lymph node involvement by gastric carcinoma. Int J Oncol 25: 1319-1325, 2004.
APA
Kosaka, K., Yashiro, M., Sakate, Y., Tanaka, H., Sunami, T., Ohira, M., & Hirakawa, K. (2004). CD80 gene therapy for lymph node involvement by gastric carcinoma. International Journal of Oncology, 25, 1319-1325. https://doi.org/10.3892/ijo.25.5.1319
MLA
Kosaka, K., Yashiro, M., Sakate, Y., Tanaka, H., Sunami, T., Ohira, M., Hirakawa, K."CD80 gene therapy for lymph node involvement by gastric carcinoma". International Journal of Oncology 25.5 (2004): 1319-1325.
Chicago
Kosaka, K., Yashiro, M., Sakate, Y., Tanaka, H., Sunami, T., Ohira, M., Hirakawa, K."CD80 gene therapy for lymph node involvement by gastric carcinoma". International Journal of Oncology 25, no. 5 (2004): 1319-1325. https://doi.org/10.3892/ijo.25.5.1319
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