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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2004 Volume 25 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2004 Volume 25 Issue 5

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Article

A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer

  • Authors:
    • Ryuichiro Yagyu
    • Yoichi Furukawa
    • Yu-Min Lin
    • Takashi Shimokawa
    • Takehira Yamamura
    • Yusuke Nakamura

  • View Affiliations / Copyright

    Affiliations: Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan
  • Pages: 1343-1348
    |
    Published online on: November 1, 2004
       https://doi.org/10.3892/ijo.25.5.1343
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Abstract

We previously analyzed expression profiles of 20 colorectal tumors by means of genome-wide cDNA microarray. Among the genes that were commonly up-regulated in the CRCs, we further characterized biological importance of a novel human gene termed RNF43 (RING finger protein 43) in colorectal carcinogenesis. Multiple-tissue northern blot analysis revealed undetectable expression of RNF43 in normal adult tissues examined and low levels of expression in fetal kidney and lung. Its exogenous expression conferred a growth-promoting effect in COS7 and NIH3T3 cells, and suppression of its expression by specific short interfering RNAs retarded the growth of colon cancer cells. Interestingly, RNF43 protein was shown to be a secreted protein, and addition of the conditioned media of the RNF43-transfected cells into culture media of NIH3T3 cells revealed a significant enhancement of cell growth. These data suggest that RNF43 may exert its growth promoting effect in an antocrine manner, and that it may be a novel diagnostic marker for colorectal cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Yagyu R, Furukawa Y, Lin Y, Shimokawa T, Yamamura T and Nakamura Y: A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer. Int J Oncol 25: 1343-1348, 2004.
APA
Yagyu, R., Furukawa, Y., Lin, Y., Shimokawa, T., Yamamura, T., & Nakamura, Y. (2004). A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer. International Journal of Oncology, 25, 1343-1348. https://doi.org/10.3892/ijo.25.5.1343
MLA
Yagyu, R., Furukawa, Y., Lin, Y., Shimokawa, T., Yamamura, T., Nakamura, Y."A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer". International Journal of Oncology 25.5 (2004): 1343-1348.
Chicago
Yagyu, R., Furukawa, Y., Lin, Y., Shimokawa, T., Yamamura, T., Nakamura, Y."A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer". International Journal of Oncology 25, no. 5 (2004): 1343-1348. https://doi.org/10.3892/ijo.25.5.1343
Copy and paste a formatted citation
x
Spandidos Publications style
Yagyu R, Furukawa Y, Lin Y, Shimokawa T, Yamamura T and Nakamura Y: A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer. Int J Oncol 25: 1343-1348, 2004.
APA
Yagyu, R., Furukawa, Y., Lin, Y., Shimokawa, T., Yamamura, T., & Nakamura, Y. (2004). A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer. International Journal of Oncology, 25, 1343-1348. https://doi.org/10.3892/ijo.25.5.1343
MLA
Yagyu, R., Furukawa, Y., Lin, Y., Shimokawa, T., Yamamura, T., Nakamura, Y."A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer". International Journal of Oncology 25.5 (2004): 1343-1348.
Chicago
Yagyu, R., Furukawa, Y., Lin, Y., Shimokawa, T., Yamamura, T., Nakamura, Y."A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer". International Journal of Oncology 25, no. 5 (2004): 1343-1348. https://doi.org/10.3892/ijo.25.5.1343
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