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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2004 Volume 25 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2004 Volume 25 Issue 6

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Article

Arrangement of expression and distribution of tight junction protein claudin-1 in cell dissociation of pancreatic cancer cells

  • Authors:
    • Xiaodong Tan
    • Hiroshi Egami
    • Shinji Ishikawa
    • Takashi Kurizaki
    • Masahide Nakagawa
    • Masahiko Hirota
    • Michio Ogawa

  • View Affiliations / Copyright

    Affiliations: Department of Surgery II, Kumamoto University Medical School, Kumamoto, Japan
  • Pages: 1567-1574
    |
    Published online on: December 1, 2004
       https://doi.org/10.3892/ijo.25.6.1567
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Abstract

Mitogen-activated protein kinase kinase 2 (MEK2) was isolated previously as a potential factor related to cancer cell dissociation in highly (PC-1.0) and weakly (PC-1) invasive pancreatic cancer cells. On the other hand, changes of structure and function of tight junction (TJ) are reported to be correlated with carcinogenesis and tumor development. In this study, immunocytochemistry and Western blot analysis were performed in pancreatic cancer cells using anti-claudin-1, MEK2 and phosphorylated MEK1/2 (p-MEK1/2) antibodies to reveal the correlation between TJ and cancer cell dissociation, as well as the involvement of MEK2 in regulation of TJ in cell dissociation of pancreatic cancer. After incubation with conditioned medium of PC-1.0 cells, plasma membrane distribution of claudin-1 was obviously disrupted, and expressions of MEK2 and p-MEK1/2, as well as dissociation of cell colonies, were significantly induced in PC-1 and CAPAN-2 cells. However, U0126 (a MEK1/2 inhibitor) treatment apparently induced the plasma membrane distribution of claudin-1 and aggregation of single cells in PC-1.0 and AsPC-1 cells, synchronously seriously suppressed MEK2 and p-MEK1/2 expression. Arrangement of expression and distribution of claudin-1 is closely related to cell dissociation status in pancreatic cancer cells through MEK2 activation.

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Copy and paste a formatted citation
Spandidos Publications style
Tan X, Egami H, Ishikawa S, Kurizaki T, Nakagawa M, Hirota M and Ogawa M: Arrangement of expression and distribution of tight junction protein claudin-1 in cell dissociation of pancreatic cancer cells. Int J Oncol 25: 1567-1574, 2004.
APA
Tan, X., Egami, H., Ishikawa, S., Kurizaki, T., Nakagawa, M., Hirota, M., & Ogawa, M. (2004). Arrangement of expression and distribution of tight junction protein claudin-1 in cell dissociation of pancreatic cancer cells. International Journal of Oncology, 25, 1567-1574. https://doi.org/10.3892/ijo.25.6.1567
MLA
Tan, X., Egami, H., Ishikawa, S., Kurizaki, T., Nakagawa, M., Hirota, M., Ogawa, M."Arrangement of expression and distribution of tight junction protein claudin-1 in cell dissociation of pancreatic cancer cells". International Journal of Oncology 25.6 (2004): 1567-1574.
Chicago
Tan, X., Egami, H., Ishikawa, S., Kurizaki, T., Nakagawa, M., Hirota, M., Ogawa, M."Arrangement of expression and distribution of tight junction protein claudin-1 in cell dissociation of pancreatic cancer cells". International Journal of Oncology 25, no. 6 (2004): 1567-1574. https://doi.org/10.3892/ijo.25.6.1567
Copy and paste a formatted citation
x
Spandidos Publications style
Tan X, Egami H, Ishikawa S, Kurizaki T, Nakagawa M, Hirota M and Ogawa M: Arrangement of expression and distribution of tight junction protein claudin-1 in cell dissociation of pancreatic cancer cells. Int J Oncol 25: 1567-1574, 2004.
APA
Tan, X., Egami, H., Ishikawa, S., Kurizaki, T., Nakagawa, M., Hirota, M., & Ogawa, M. (2004). Arrangement of expression and distribution of tight junction protein claudin-1 in cell dissociation of pancreatic cancer cells. International Journal of Oncology, 25, 1567-1574. https://doi.org/10.3892/ijo.25.6.1567
MLA
Tan, X., Egami, H., Ishikawa, S., Kurizaki, T., Nakagawa, M., Hirota, M., Ogawa, M."Arrangement of expression and distribution of tight junction protein claudin-1 in cell dissociation of pancreatic cancer cells". International Journal of Oncology 25.6 (2004): 1567-1574.
Chicago
Tan, X., Egami, H., Ishikawa, S., Kurizaki, T., Nakagawa, M., Hirota, M., Ogawa, M."Arrangement of expression and distribution of tight junction protein claudin-1 in cell dissociation of pancreatic cancer cells". International Journal of Oncology 25, no. 6 (2004): 1567-1574. https://doi.org/10.3892/ijo.25.6.1567
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