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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2004 Volume 25 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2004 Volume 25 Issue 6

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Article

Aurora-A/STK15/BTAK enhances chromosomal instability in bladder cancer cells

  • Authors:
    • Gail C. Fraizer
    • Miguel F. Diaz
    • I.-Ling Lee
    • H. Barton Grossman
    • Subrata Sen

  • View Affiliations / Copyright

    Affiliations: Department of Biological Science, Kent State University, Kent, OH 44242, USA. gfraizer@kent.edu
  • Pages: 1631-1639
    |
    Published online on: December 1, 2004
       https://doi.org/10.3892/ijo.25.6.1631
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Abstract

Chromosomal aneuploidy is associated with invasive bladder cancer and one of the genes implicated in these changes is Aurora-A/STK15/BTAK, that is localized on chromosome 20q13 and encodes a centrosome-associated serine/threonine kinase. To better understand the association between Aurora-A/STK15 expression, tumor aneuploidy and clinical prognosis, we sought to determine whether overexpression of Aurora-A/STK15 in cultured urothelial cells facilitated chromosomal instability. Using immunofluorescence staining, Northern and Western blot analyses, we verified that overexpression of Aurora-A/STK15 in bladder tumor cell lines enhanced chromosomal instability. Additionally, we observed that some bladder tumor cell lines expressed more Aurora-A/STK15 than cultured normal urothelial cells and that Aurora-A/STK15 expression was higher in an immortalized E7 urothelial cell line having 20q amplification than in an E6 line lacking 20q amplification. These results were consistent with our observations of higher mRNA levels in some T3 invasive bladder tumors than in T1 superficial tumors and adjacent normal bladder tissue. Overall our results suggest that overexpression of Aurora-A/STK15 in bladder tumor cells contributes to tumor progression by promoting chromosomal instability leading to aneuploidy.

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Copy and paste a formatted citation
Spandidos Publications style
Fraizer GC, Diaz MF, Lee I, Grossman HB and Sen S: Aurora-A/STK15/BTAK enhances chromosomal instability in bladder cancer cells. Int J Oncol 25: 1631-1639, 2004.
APA
Fraizer, G.C., Diaz, M.F., Lee, I., Grossman, H.B., & Sen, S. (2004). Aurora-A/STK15/BTAK enhances chromosomal instability in bladder cancer cells. International Journal of Oncology, 25, 1631-1639. https://doi.org/10.3892/ijo.25.6.1631
MLA
Fraizer, G. C., Diaz, M. F., Lee, I., Grossman, H. B., Sen, S."Aurora-A/STK15/BTAK enhances chromosomal instability in bladder cancer cells". International Journal of Oncology 25.6 (2004): 1631-1639.
Chicago
Fraizer, G. C., Diaz, M. F., Lee, I., Grossman, H. B., Sen, S."Aurora-A/STK15/BTAK enhances chromosomal instability in bladder cancer cells". International Journal of Oncology 25, no. 6 (2004): 1631-1639. https://doi.org/10.3892/ijo.25.6.1631
Copy and paste a formatted citation
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Spandidos Publications style
Fraizer GC, Diaz MF, Lee I, Grossman HB and Sen S: Aurora-A/STK15/BTAK enhances chromosomal instability in bladder cancer cells. Int J Oncol 25: 1631-1639, 2004.
APA
Fraizer, G.C., Diaz, M.F., Lee, I., Grossman, H.B., & Sen, S. (2004). Aurora-A/STK15/BTAK enhances chromosomal instability in bladder cancer cells. International Journal of Oncology, 25, 1631-1639. https://doi.org/10.3892/ijo.25.6.1631
MLA
Fraizer, G. C., Diaz, M. F., Lee, I., Grossman, H. B., Sen, S."Aurora-A/STK15/BTAK enhances chromosomal instability in bladder cancer cells". International Journal of Oncology 25.6 (2004): 1631-1639.
Chicago
Fraizer, G. C., Diaz, M. F., Lee, I., Grossman, H. B., Sen, S."Aurora-A/STK15/BTAK enhances chromosomal instability in bladder cancer cells". International Journal of Oncology 25, no. 6 (2004): 1631-1639. https://doi.org/10.3892/ijo.25.6.1631
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