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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2004 Volume 25 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2004 Volume 25 Issue 6

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Article

Valproic acid and interferon-α synergistically inhibit neuroblastoma cell growth in vitro and in vivo

  • Authors:
    • Martin Michaelis
    • Tatyana Suhan
    • Jaroslav Cinatl
    • Pablo Hernáiz Driever
    • Jindrich Cinatl

  • View Affiliations / Copyright

    Affiliations: Institut für Medizinische Virologie, Klinikum der J.W. Goethe Universität, 60596 Frankfurt am Main, Germany
  • Pages: 1795-1799
    |
    Published online on: December 1, 2004
       https://doi.org/10.3892/ijo.25.6.1795
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Abstract

Valproic acid (VPA) as a differentiation inducing anti-neoplastic substance is currently tested in solid tumour and leukaemia patients. Previously, we were able to show that the anti-cancer activity of VPA was synergistically increased by interferon-α (IFN-α) in Be(2)-C neuroblastoma (NB) cells. Now, we studied the effects of VPA in combination with IFN-α on two other NB cell lines. UKF-NB-2 and UKF-NB-3 cell growth was synergistically inhibited by VPA and IFN-α. Cell cycle investigations revealed massive accumulation of cells in G0/G1-phase after a combined treatment with VPA and IFN-α. The VPA-induced accumulation of acetylated histones in NB cell nuclei that indicates inhibition of histone deacetylases was not further enhanced by the combination treatment with IFN-α. Most strikingly, VPA plus IFN-α synergistically inhibited growth of UKF-NB-3 xenograft tumours in nude mice and induced complete cures in two out of six animals, while single treatment merely inhibited tumour growth. The results of this study together with our previous report strongly encourage the clinical evaluation of VPA and IFN-α for NB patients.

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Copy and paste a formatted citation
Spandidos Publications style
Michaelis M, Suhan T, Cinatl J, Driever PH and Cinatl J: Valproic acid and interferon-α synergistically inhibit neuroblastoma cell growth in vitro and in vivo. Int J Oncol 25: 1795-1799, 2004.
APA
Michaelis, M., Suhan, T., Cinatl, J., Driever, P.H., & Cinatl, J. (2004). Valproic acid and interferon-α synergistically inhibit neuroblastoma cell growth in vitro and in vivo. International Journal of Oncology, 25, 1795-1799. https://doi.org/10.3892/ijo.25.6.1795
MLA
Michaelis, M., Suhan, T., Cinatl, J., Driever, P. H., Cinatl, J."Valproic acid and interferon-α synergistically inhibit neuroblastoma cell growth in vitro and in vivo". International Journal of Oncology 25.6 (2004): 1795-1799.
Chicago
Michaelis, M., Suhan, T., Cinatl, J., Driever, P. H., Cinatl, J."Valproic acid and interferon-α synergistically inhibit neuroblastoma cell growth in vitro and in vivo". International Journal of Oncology 25, no. 6 (2004): 1795-1799. https://doi.org/10.3892/ijo.25.6.1795
Copy and paste a formatted citation
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Spandidos Publications style
Michaelis M, Suhan T, Cinatl J, Driever PH and Cinatl J: Valproic acid and interferon-α synergistically inhibit neuroblastoma cell growth in vitro and in vivo. Int J Oncol 25: 1795-1799, 2004.
APA
Michaelis, M., Suhan, T., Cinatl, J., Driever, P.H., & Cinatl, J. (2004). Valproic acid and interferon-α synergistically inhibit neuroblastoma cell growth in vitro and in vivo. International Journal of Oncology, 25, 1795-1799. https://doi.org/10.3892/ijo.25.6.1795
MLA
Michaelis, M., Suhan, T., Cinatl, J., Driever, P. H., Cinatl, J."Valproic acid and interferon-α synergistically inhibit neuroblastoma cell growth in vitro and in vivo". International Journal of Oncology 25.6 (2004): 1795-1799.
Chicago
Michaelis, M., Suhan, T., Cinatl, J., Driever, P. H., Cinatl, J."Valproic acid and interferon-α synergistically inhibit neuroblastoma cell growth in vitro and in vivo". International Journal of Oncology 25, no. 6 (2004): 1795-1799. https://doi.org/10.3892/ijo.25.6.1795
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