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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2005 Volume 26 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

The der(12)t(12;16) breakpoint in an acute leukaemia case targets a Sec7 domain containing protein

  • Authors:
    • Anniek Corveleyn
    • Iwona Wlodarska
    • Cristina Mecucci
    • Peter Marynen

  • View Affiliations / Copyright

    Affiliations: Human Genome Laboratory, Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology (VIB), Katholieke Universiteit Leuven, B-3000 Leuven, Belgium
  • Pages: 1111-1120
    |
    Published online on: April 1, 2005
       https://doi.org/10.3892/ijo.26.4.1111
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Abstract

A balanced translocation t(12;16)(p13;p13) in a patient with AML-M1 and bone marrow eosinophilia was previously analysed by FISH. The 16p13 breakpoint was shown to occur in the MYH11 gene, the fusion partner of CBFβ in leukaemia patients with an inv(16) or a t(16;16), whereas the 12p13 breakpoint was shown to be present in cosmid c4H9. We present the molecular analysis of c4H9, resulting in the identification of a novel gene, SLAG. At the N-terminus, SLAG contains a Sec7 domain also found in proteins of the cytohesin family. In contrast to the cytohesins, no pleckstrin homology domain is present in SLAG. database searches identified several homologues, suggesting that SLAG defines a new subfamily of Sec7 proteins, characterised by an N-terminal Sec7 domain and a new C-terminal pleckstrin homology-like domain. The FISH data led to the hypothesis that rearrangement of SLAG might be involved in the pathogenesis of AML through the generation of a new fusion gene with MYH11. However, the putative SLAG-MYH11 fusions showed only weak transforming properties in NIH3T3 cells in a focus formation assay.

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Copy and paste a formatted citation
Spandidos Publications style
Corveleyn A, Wlodarska I, Mecucci C and Marynen P: The der(12)t(12;16) breakpoint in an acute leukaemia case targets a Sec7 domain containing protein. Int J Oncol 26: 1111-1120, 2005.
APA
Corveleyn, A., Wlodarska, I., Mecucci, C., & Marynen, P. (2005). The der(12)t(12;16) breakpoint in an acute leukaemia case targets a Sec7 domain containing protein. International Journal of Oncology, 26, 1111-1120. https://doi.org/10.3892/ijo.26.4.1111
MLA
Corveleyn, A., Wlodarska, I., Mecucci, C., Marynen, P."The der(12)t(12;16) breakpoint in an acute leukaemia case targets a Sec7 domain containing protein". International Journal of Oncology 26.4 (2005): 1111-1120.
Chicago
Corveleyn, A., Wlodarska, I., Mecucci, C., Marynen, P."The der(12)t(12;16) breakpoint in an acute leukaemia case targets a Sec7 domain containing protein". International Journal of Oncology 26, no. 4 (2005): 1111-1120. https://doi.org/10.3892/ijo.26.4.1111
Copy and paste a formatted citation
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Spandidos Publications style
Corveleyn A, Wlodarska I, Mecucci C and Marynen P: The der(12)t(12;16) breakpoint in an acute leukaemia case targets a Sec7 domain containing protein. Int J Oncol 26: 1111-1120, 2005.
APA
Corveleyn, A., Wlodarska, I., Mecucci, C., & Marynen, P. (2005). The der(12)t(12;16) breakpoint in an acute leukaemia case targets a Sec7 domain containing protein. International Journal of Oncology, 26, 1111-1120. https://doi.org/10.3892/ijo.26.4.1111
MLA
Corveleyn, A., Wlodarska, I., Mecucci, C., Marynen, P."The der(12)t(12;16) breakpoint in an acute leukaemia case targets a Sec7 domain containing protein". International Journal of Oncology 26.4 (2005): 1111-1120.
Chicago
Corveleyn, A., Wlodarska, I., Mecucci, C., Marynen, P."The der(12)t(12;16) breakpoint in an acute leukaemia case targets a Sec7 domain containing protein". International Journal of Oncology 26, no. 4 (2005): 1111-1120. https://doi.org/10.3892/ijo.26.4.1111
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