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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2005 Volume 26 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2005 Volume 26 Issue 4

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Article

Proteome-based identification of molecular markers predicting chemosensitivity to each category of anticancer agents in human gliomas

  • Authors:
    • Yasuo Iwadate
    • Tsukasa Sakaida
    • Takashi Saegusa
    • Takaki Hiwasa
    • Masaki Takiguchi
    • Shuichi Fujimoto
    • Akira Yamaura

  • View Affiliations / Copyright

    Affiliations: Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan. iwadatey@faculty.chiba-u.jp
  • Pages: 993-998
    |
    Published online on: April 1, 2005
       https://doi.org/10.3892/ijo.26.4.993
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Abstract

To identify the protein markers that are clinically useful for predicting efficacy of anticancer agents, we investigated the correlation between the proteome profiling patterns and the in vitro chemosensitivity in human gliomas. The proteome of 93 surgical samples were analyzed with two-dimensional gel electrophoresis (2DE) and mass spectrometry. The in vitro chemosensitivities to 10 different kinds of anticancer agents (cyclophosphamide, nimustine, cisplatin, cytosine arabinoside, mitomycin C, peplomycin, adriamycin, etoposide, vincristine, paclitaxel) were measured by flow cytometric detection of apoptosis. We identified a set of 41 proteins that significantly affected the in vitro chemosensitivity to each category of anticancer agents. Many of the proteins that correlated with chemoresistance were categorized into the signal transduction proteins including the G-proteins. The present study showed that the proteome analysis using 2DE could provide a list of proteins that may be the potential predictive markers for chemosensitivity in human gliomas. They can also be direct and rational targets for anti-glioma therapy and be used for sensitization to the conventional chemotherapeutic regimens.

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Copy and paste a formatted citation
Spandidos Publications style
Iwadate Y, Sakaida T, Saegusa T, Hiwasa T, Takiguchi M, Fujimoto S and Yamaura A: Proteome-based identification of molecular markers predicting chemosensitivity to each category of anticancer agents in human gliomas. Int J Oncol 26: 993-998, 2005.
APA
Iwadate, Y., Sakaida, T., Saegusa, T., Hiwasa, T., Takiguchi, M., Fujimoto, S., & Yamaura, A. (2005). Proteome-based identification of molecular markers predicting chemosensitivity to each category of anticancer agents in human gliomas. International Journal of Oncology, 26, 993-998. https://doi.org/10.3892/ijo.26.4.993
MLA
Iwadate, Y., Sakaida, T., Saegusa, T., Hiwasa, T., Takiguchi, M., Fujimoto, S., Yamaura, A."Proteome-based identification of molecular markers predicting chemosensitivity to each category of anticancer agents in human gliomas". International Journal of Oncology 26.4 (2005): 993-998.
Chicago
Iwadate, Y., Sakaida, T., Saegusa, T., Hiwasa, T., Takiguchi, M., Fujimoto, S., Yamaura, A."Proteome-based identification of molecular markers predicting chemosensitivity to each category of anticancer agents in human gliomas". International Journal of Oncology 26, no. 4 (2005): 993-998. https://doi.org/10.3892/ijo.26.4.993
Copy and paste a formatted citation
x
Spandidos Publications style
Iwadate Y, Sakaida T, Saegusa T, Hiwasa T, Takiguchi M, Fujimoto S and Yamaura A: Proteome-based identification of molecular markers predicting chemosensitivity to each category of anticancer agents in human gliomas. Int J Oncol 26: 993-998, 2005.
APA
Iwadate, Y., Sakaida, T., Saegusa, T., Hiwasa, T., Takiguchi, M., Fujimoto, S., & Yamaura, A. (2005). Proteome-based identification of molecular markers predicting chemosensitivity to each category of anticancer agents in human gliomas. International Journal of Oncology, 26, 993-998. https://doi.org/10.3892/ijo.26.4.993
MLA
Iwadate, Y., Sakaida, T., Saegusa, T., Hiwasa, T., Takiguchi, M., Fujimoto, S., Yamaura, A."Proteome-based identification of molecular markers predicting chemosensitivity to each category of anticancer agents in human gliomas". International Journal of Oncology 26.4 (2005): 993-998.
Chicago
Iwadate, Y., Sakaida, T., Saegusa, T., Hiwasa, T., Takiguchi, M., Fujimoto, S., Yamaura, A."Proteome-based identification of molecular markers predicting chemosensitivity to each category of anticancer agents in human gliomas". International Journal of Oncology 26, no. 4 (2005): 993-998. https://doi.org/10.3892/ijo.26.4.993
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