Tumor and metastasis suppression by the human RNASET2 gene

Acquati,Francesco; Possati,Laura; Ferrante,Luigi; Campomenosi,Paola; Talevi,Simona; Bardelli,Silvana; Margiotta,Chiara; Russo,Antonella; Bortoletto,Elisabetta; Rocchetti,Romina; Calza,Roberta; Cinquetti,Raffaella; Monti,Laura; Salis,Silvia; Barbanti-Brodano,Giuseppe; Taramelli,Roberto

doi:10.3892/ijo.26.5.1159

May 2005 Volume 26 Issue 5

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May 2005 Volume 26 Issue 5

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Article

Tumor and metastasis suppression by the human RNASET2 gene

Authors:
- Francesco Acquati
- Laura Possati
- Luigi Ferrante
- Paola Campomenosi
- Simona Talevi
- Silvana Bardelli
- Chiara Margiotta
- Antonella Russo
- Elisabetta Bortoletto
- Romina Rocchetti
- Roberta Calza
- Raffaella Cinquetti
- Laura Monti
- Silvia Salis
- Giuseppe Barbanti-Brodano
- Roberto Taramelli
View Affiliations / Copyright

Affiliations: Dipartimento di Biotecnologie e Scienze Molecolari, Università degli Studi dell'Insubria, I-21100 Varese, Italy. francesco.acquati@uninsubria.it
Pages: 1159-1168
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Published online on: May 1, 2005

https://doi.org/10.3892/ijo.26.5.1159
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Abstract

The region 6q27 from human chromosome 6 has been reported to contain one or more tumor suppressor genes on the basis of cytogenetic, molecular and functional studies. We have recently carried out a detailed analysis of a candidate gene from 6q27 to evaluate its putative role as a tumor suppressor gene involved in ovarian cancer pathogenesis. The RNASET2 gene was shown to behave as a class II tumor suppressor and abolish the tumorigenic potential of an ovarian cancer-derived cell line. In this study, we have started the cellular and biochemical characterization of RNASET2 and showed that it is a secreted glycoprotein. Moreover, we have extended our previous studies by evaluating the effect of RNASET2 on the metastatic behavior of the highly-invasive ovarian cancer cell line HEY3MET2. From such analysis, RNASET2 was found to significantly decrease the metastatic potential of this cell line in vivo. Moreover, RNASET2-mediated suppression of tumorigenesis and metastasis was not affected by a double point mutation targeted to the putative ribonuclease catalytic sites, suggesting that tumor suppression by RNASET2 is not mediated by its ribonuclease activity. The potential biological implications of this unexpected finding are discussed in relation to the current evolutionary models.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Tumor and metastasis suppression by the human RNASET2 gene

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Abstract

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