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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 2005 Volume 26 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2005 Volume 26 Issue 5

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Article

Loss of caspase-1 gene expression in human gastric carcinomas and cell lines

  • Authors:
    • Chang Do Jee
    • Hye Seung Lee
    • Soo In Bae
    • Han Kwang Yang
    • You Mie Lee
    • Min Suk Rho
    • Woo Ho Kim

  • View Affiliations / Copyright

    Affiliations: Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea
  • Pages: 1265-1271
    |
    Published online on: May 1, 2005
       https://doi.org/10.3892/ijo.26.5.1265
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Abstract

The caspases are a family of aspartic acid-specific proteases that fulfill varied and often critical roles in mammalian apoptosis or in the proteolytic activation of cytokines. Caspase-1 (interleukin-1β-converting enzyme) is a member of the cysteine protease family, which cleaves target proteins following aspartic acid residues. We investigated caspase-1 expression in stomach cancer, tissues and cell lines. Of 301 consecutive gastric carcinomas, 58 cases (19.3%) showed the expressional loss of caspase-1. Loss of caspase-1 expression was significantly associated with pTNM stage (p=0.03), lymph node metastasis (p=0.01) and patient survival (p<0.01). Caspase-1 expression was also significantly correlated in an inverse manner with p53 expression (p<0.01). Among the 11 gastric cancer cell lines examined, three cell lines showed loss of expression at the protein and mRNA levels. On treatment with 5-aza-2'-deoxycytidine (5-aza-C), and/or trichostatin A (TSA), all three cell lines re-expressed caspase-1 mRNA. The above findings suggest that epigenetic events such as DNA methylation and histone deacetylation play important roles in the regulation of caspase-1, and that loss of caspase-1 expression is associated with poor survival in gastric carcinoma.

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Copy and paste a formatted citation
Spandidos Publications style
Jee CD, Lee HS, Bae SI, Yang HK, Lee YM, Rho MS and Kim WH: Loss of caspase-1 gene expression in human gastric carcinomas and cell lines. Int J Oncol 26: 1265-1271, 2005.
APA
Jee, C.D., Lee, H.S., Bae, S.I., Yang, H.K., Lee, Y.M., Rho, M.S., & Kim, W.H. (2005). Loss of caspase-1 gene expression in human gastric carcinomas and cell lines. International Journal of Oncology, 26, 1265-1271. https://doi.org/10.3892/ijo.26.5.1265
MLA
Jee, C. D., Lee, H. S., Bae, S. I., Yang, H. K., Lee, Y. M., Rho, M. S., Kim, W. H."Loss of caspase-1 gene expression in human gastric carcinomas and cell lines". International Journal of Oncology 26.5 (2005): 1265-1271.
Chicago
Jee, C. D., Lee, H. S., Bae, S. I., Yang, H. K., Lee, Y. M., Rho, M. S., Kim, W. H."Loss of caspase-1 gene expression in human gastric carcinomas and cell lines". International Journal of Oncology 26, no. 5 (2005): 1265-1271. https://doi.org/10.3892/ijo.26.5.1265
Copy and paste a formatted citation
x
Spandidos Publications style
Jee CD, Lee HS, Bae SI, Yang HK, Lee YM, Rho MS and Kim WH: Loss of caspase-1 gene expression in human gastric carcinomas and cell lines. Int J Oncol 26: 1265-1271, 2005.
APA
Jee, C.D., Lee, H.S., Bae, S.I., Yang, H.K., Lee, Y.M., Rho, M.S., & Kim, W.H. (2005). Loss of caspase-1 gene expression in human gastric carcinomas and cell lines. International Journal of Oncology, 26, 1265-1271. https://doi.org/10.3892/ijo.26.5.1265
MLA
Jee, C. D., Lee, H. S., Bae, S. I., Yang, H. K., Lee, Y. M., Rho, M. S., Kim, W. H."Loss of caspase-1 gene expression in human gastric carcinomas and cell lines". International Journal of Oncology 26.5 (2005): 1265-1271.
Chicago
Jee, C. D., Lee, H. S., Bae, S. I., Yang, H. K., Lee, Y. M., Rho, M. S., Kim, W. H."Loss of caspase-1 gene expression in human gastric carcinomas and cell lines". International Journal of Oncology 26, no. 5 (2005): 1265-1271. https://doi.org/10.3892/ijo.26.5.1265
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