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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2005 Volume 26 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2005 Volume 26 Issue 6

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Article

Expression of bone morphogenetic protein 2 in breast cancer cells inhibits hypoxic cell death

  • Authors:
    • Martin Raida
    • Joachim H. Clement
    • Kurosh Ameri
    • Cheng Han
    • Russell D. Leek
    • Adrian. L. Harris

  • View Affiliations / Copyright

    Affiliations: University Hospital of Leipzig, Department of Hematology and Oncology, D-04103 Leipzig, Germany. martin.raida@medizin.uni-leipzig.de
  • Pages: 1465-1470
    |
    Published online on: June 1, 2005
       https://doi.org/10.3892/ijo.26.6.1465
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Abstract

BMP-2 is involved in the fetal and postnatal development of the mammary gland but has also been detected in breast cancer cells. To clarify the biological role of BMP-2 in breast cancer, we used the human breast cancer cell line MCF-7. Incubation with BMP-2 under serum-free conditions induced activation of the mitogen activated protein kinases (MAPKs) ERK1/2 and the basic helix-loop-helix transcription factors Id-1, proteins that can protect from apoptosis. Stably transfected MCF-7 cells overexpressing BMP-2 revealed significantly increased resistance to hypoxia-induced apoptosis compared to empty vector controls. Cytoplasmic BMP-2/4 protein expression was detected in carcinoma cells of 81 samples of invasive breast cancer in contrast to adjacent normal mammary epithelial cells. BMP-2/4 expression did not correlate with common prognostic parameters and was not associated with relapse-free or overall survival. We conclude that BMP-2/4 expression is reactivated in invasive breast cancer and part of an autocrine/paracrine mechanism rescuing malignant cells from hypoxic cell death via activation of the MAPK and Id-1 pathway.

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Copy and paste a formatted citation
Spandidos Publications style
Raida M, Clement JH, Ameri K, Han C, Leek RD and Harris AL: Expression of bone morphogenetic protein 2 in breast cancer cells inhibits hypoxic cell death. Int J Oncol 26: 1465-1470, 2005.
APA
Raida, M., Clement, J.H., Ameri, K., Han, C., Leek, R.D., & Harris, A.L. (2005). Expression of bone morphogenetic protein 2 in breast cancer cells inhibits hypoxic cell death. International Journal of Oncology, 26, 1465-1470. https://doi.org/10.3892/ijo.26.6.1465
MLA
Raida, M., Clement, J. H., Ameri, K., Han, C., Leek, R. D., Harris, A. L."Expression of bone morphogenetic protein 2 in breast cancer cells inhibits hypoxic cell death". International Journal of Oncology 26.6 (2005): 1465-1470.
Chicago
Raida, M., Clement, J. H., Ameri, K., Han, C., Leek, R. D., Harris, A. L."Expression of bone morphogenetic protein 2 in breast cancer cells inhibits hypoxic cell death". International Journal of Oncology 26, no. 6 (2005): 1465-1470. https://doi.org/10.3892/ijo.26.6.1465
Copy and paste a formatted citation
x
Spandidos Publications style
Raida M, Clement JH, Ameri K, Han C, Leek RD and Harris AL: Expression of bone morphogenetic protein 2 in breast cancer cells inhibits hypoxic cell death. Int J Oncol 26: 1465-1470, 2005.
APA
Raida, M., Clement, J.H., Ameri, K., Han, C., Leek, R.D., & Harris, A.L. (2005). Expression of bone morphogenetic protein 2 in breast cancer cells inhibits hypoxic cell death. International Journal of Oncology, 26, 1465-1470. https://doi.org/10.3892/ijo.26.6.1465
MLA
Raida, M., Clement, J. H., Ameri, K., Han, C., Leek, R. D., Harris, A. L."Expression of bone morphogenetic protein 2 in breast cancer cells inhibits hypoxic cell death". International Journal of Oncology 26.6 (2005): 1465-1470.
Chicago
Raida, M., Clement, J. H., Ameri, K., Han, C., Leek, R. D., Harris, A. L."Expression of bone morphogenetic protein 2 in breast cancer cells inhibits hypoxic cell death". International Journal of Oncology 26, no. 6 (2005): 1465-1470. https://doi.org/10.3892/ijo.26.6.1465
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