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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2005 Volume 26 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Dual lympho-myeloproliferative disorder in a patient with t(8;22) with BCR-FGFR1 gene fusion

  • Authors:
    • Anne Murati
    • Christine Arnoulet
    • Marina Lafage-Pochitaloff
    • José Adélaide
    • Martine Derré
    • Borhane Slama
    • Bénédicte Delaval
    • Cornel Popovici
    • Norbert Vey
    • Luc Xerri
    • Marie Joelle Mozziconacci
    • Olivier Boulat
    • Danielle Sainty
    • Daniel Birnbaum
    • Max Chaffanet

  • View Affiliations / Copyright

    Affiliations: Department of Molecular Oncology, Marseille Cancer Institute, UMR599 Inserm and Paoli-Calmettes Institute, France
  • Pages: 1485-1492
    |
    Published online on: June 1, 2005
       https://doi.org/10.3892/ijo.26.6.1485
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Abstract

The case of a patient presenting with a myeloproliferative disorder (MPD) characterized by a t(8;22) (p12;q11) translocation was investigated. The rearrangement resulted in the production of BCR-FGFR1 and FGFR1-BCR chimeric transcripts after in-frame fusions of BCR exon 4 with FGFR1 exon 9 and FGFR1 exon 8 with BCR exon 5, respectively. The four previously reported patients with such translocation presented with an atypical chronic myeloid leukemia (CML) without Philadelphia chromosome. In addition to a myeloproliferation, the patient had a B cell proliferation. The phenotypic characterization of the lymphoid cells in the bone marrow showed a continuum of maturation from blast B cells to polyclonal lymphocytes. In the blood, B cells showed a complete polyclonal maturation. The BCR-FGFR1 gene fusion was detected by dual-color fluorescence in situ hybridization in both CD19− and CD19+ populations. In contrast to the other FGFR1-MPDs that show myeloid and T cell proliferation, we propose that this t(8;22) MPD is a myeloid and B cell disease, and potentially a novel type of hematological disease. Although the FGFR1-MPD is rare, its study provides interesting clues to the understanding of hematopoietic stem cell biology and oncogene activation.

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Copy and paste a formatted citation
Spandidos Publications style
Murati A, Arnoulet C, Lafage-Pochitaloff M, Adélaide J, Derré M, Slama B, Delaval B, Popovici C, Vey N, Xerri L, Xerri L, et al: Dual lympho-myeloproliferative disorder in a patient with t(8;22) with BCR-FGFR1 gene fusion. Int J Oncol 26: 1485-1492, 2005.
APA
Murati, A., Arnoulet, C., Lafage-Pochitaloff, M., Adélaide, J., Derré, M., Slama, B. ... Chaffanet, M. (2005). Dual lympho-myeloproliferative disorder in a patient with t(8;22) with BCR-FGFR1 gene fusion. International Journal of Oncology, 26, 1485-1492. https://doi.org/10.3892/ijo.26.6.1485
MLA
Murati, A., Arnoulet, C., Lafage-Pochitaloff, M., Adélaide, J., Derré, M., Slama, B., Delaval, B., Popovici, C., Vey, N., Xerri, L., Joelle Mozziconacci, M., Boulat, O., Sainty, D., Birnbaum, D., Chaffanet, M."Dual lympho-myeloproliferative disorder in a patient with t(8;22) with BCR-FGFR1 gene fusion". International Journal of Oncology 26.6 (2005): 1485-1492.
Chicago
Murati, A., Arnoulet, C., Lafage-Pochitaloff, M., Adélaide, J., Derré, M., Slama, B., Delaval, B., Popovici, C., Vey, N., Xerri, L., Joelle Mozziconacci, M., Boulat, O., Sainty, D., Birnbaum, D., Chaffanet, M."Dual lympho-myeloproliferative disorder in a patient with t(8;22) with BCR-FGFR1 gene fusion". International Journal of Oncology 26, no. 6 (2005): 1485-1492. https://doi.org/10.3892/ijo.26.6.1485
Copy and paste a formatted citation
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Spandidos Publications style
Murati A, Arnoulet C, Lafage-Pochitaloff M, Adélaide J, Derré M, Slama B, Delaval B, Popovici C, Vey N, Xerri L, Xerri L, et al: Dual lympho-myeloproliferative disorder in a patient with t(8;22) with BCR-FGFR1 gene fusion. Int J Oncol 26: 1485-1492, 2005.
APA
Murati, A., Arnoulet, C., Lafage-Pochitaloff, M., Adélaide, J., Derré, M., Slama, B. ... Chaffanet, M. (2005). Dual lympho-myeloproliferative disorder in a patient with t(8;22) with BCR-FGFR1 gene fusion. International Journal of Oncology, 26, 1485-1492. https://doi.org/10.3892/ijo.26.6.1485
MLA
Murati, A., Arnoulet, C., Lafage-Pochitaloff, M., Adélaide, J., Derré, M., Slama, B., Delaval, B., Popovici, C., Vey, N., Xerri, L., Joelle Mozziconacci, M., Boulat, O., Sainty, D., Birnbaum, D., Chaffanet, M."Dual lympho-myeloproliferative disorder in a patient with t(8;22) with BCR-FGFR1 gene fusion". International Journal of Oncology 26.6 (2005): 1485-1492.
Chicago
Murati, A., Arnoulet, C., Lafage-Pochitaloff, M., Adélaide, J., Derré, M., Slama, B., Delaval, B., Popovici, C., Vey, N., Xerri, L., Joelle Mozziconacci, M., Boulat, O., Sainty, D., Birnbaum, D., Chaffanet, M."Dual lympho-myeloproliferative disorder in a patient with t(8;22) with BCR-FGFR1 gene fusion". International Journal of Oncology 26, no. 6 (2005): 1485-1492. https://doi.org/10.3892/ijo.26.6.1485
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