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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2005 Volume 26 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2005 Volume 26 Issue 6

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Article

Modulation of Raf/MEK/ERK kinase activity does not affect the chemoresistance profile of advanced prostate cancer cells

  • Authors:
    • John T. Lee
    • Linda S. Steelman
    • James A. McCubrey

  • View Affiliations / Copyright

    Affiliations: Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, USA
  • Pages: 1637-1644
    |
    Published online on: June 1, 2005
       https://doi.org/10.3892/ijo.26.6.1637
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Abstract

The Raf/MEK/ERK signaling cascade has been extensively studied for its roles in growth and differentiation of a variety of cell types. Confliciting evidence exists regarding the function of classical MAPK signaling with regards to the development of chemotherapeutic drug resistance; some reports describe an pro-survival role, whereas others have suggested that activation of Raf/MEK/ERK is essential for drug-induced death. To elucidate the importance of MAPK signaling in the development of advanced prostate cancer drug resistance, DU145 and PC3 prostate cells were stably-infected/transfected with constitutively-activated mutants of both Raf-1 and B-Raf. Results from MTT analyses suggested that activation of either Raf-1 or B-Raf is inconsequential in prostate cancer chemoresistance. To confirm these findings, the MAPK signal transduction cascade was activated with EGF and response to doxorubicin or paclitaxel was measured in the presence/absence of the MEK-specific inhibitor, U0126. These results showed that inhibition of signals transduced by the MAPK pathway are insufficient to affect the chemoresistance profile of advanced prostate cancer cells. Together, these data demonstrate that the response of prostatic tumors to the chemotherapeutic compounds doxorubicin and paclitaxel is independent of Raf/MEK/ERK signaling.

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Copy and paste a formatted citation
Spandidos Publications style
Lee JT, Steelman LS and McCubrey JA: Modulation of Raf/MEK/ERK kinase activity does not affect the chemoresistance profile of advanced prostate cancer cells. Int J Oncol 26: 1637-1644, 2005.
APA
Lee, J.T., Steelman, L.S., & McCubrey, J.A. (2005). Modulation of Raf/MEK/ERK kinase activity does not affect the chemoresistance profile of advanced prostate cancer cells. International Journal of Oncology, 26, 1637-1644. https://doi.org/10.3892/ijo.26.6.1637
MLA
Lee, J. T., Steelman, L. S., McCubrey, J. A."Modulation of Raf/MEK/ERK kinase activity does not affect the chemoresistance profile of advanced prostate cancer cells". International Journal of Oncology 26.6 (2005): 1637-1644.
Chicago
Lee, J. T., Steelman, L. S., McCubrey, J. A."Modulation of Raf/MEK/ERK kinase activity does not affect the chemoresistance profile of advanced prostate cancer cells". International Journal of Oncology 26, no. 6 (2005): 1637-1644. https://doi.org/10.3892/ijo.26.6.1637
Copy and paste a formatted citation
x
Spandidos Publications style
Lee JT, Steelman LS and McCubrey JA: Modulation of Raf/MEK/ERK kinase activity does not affect the chemoresistance profile of advanced prostate cancer cells. Int J Oncol 26: 1637-1644, 2005.
APA
Lee, J.T., Steelman, L.S., & McCubrey, J.A. (2005). Modulation of Raf/MEK/ERK kinase activity does not affect the chemoresistance profile of advanced prostate cancer cells. International Journal of Oncology, 26, 1637-1644. https://doi.org/10.3892/ijo.26.6.1637
MLA
Lee, J. T., Steelman, L. S., McCubrey, J. A."Modulation of Raf/MEK/ERK kinase activity does not affect the chemoresistance profile of advanced prostate cancer cells". International Journal of Oncology 26.6 (2005): 1637-1644.
Chicago
Lee, J. T., Steelman, L. S., McCubrey, J. A."Modulation of Raf/MEK/ERK kinase activity does not affect the chemoresistance profile of advanced prostate cancer cells". International Journal of Oncology 26, no. 6 (2005): 1637-1644. https://doi.org/10.3892/ijo.26.6.1637
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