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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2005 Volume 27 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2005 Volume 27 Issue 1

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Article

Expression of transcription factor Yin Yang 1 in prostate cancer

  • Authors:
    • David Seligson
    • Steve Horvath
    • Sara Huerta-Yepez
    • Stephanie Hanna
    • Hermes Garban
    • Alice Roberts
    • Tao Shi
    • Xueli Liu
    • David Chia
    • Lee Goodglick
    • Benjamin Bonavida

  • View Affiliations / Copyright

    Affiliations: Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA
  • Pages: 131-141
    |
    Published online on: July 1, 2005
       https://doi.org/10.3892/ijo.27.1.131
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Abstract

The transcription repressor Yin Yang 1 (YY1) is expressed in several human cancer cell lines and its expression correlates with resistance to immune-mediated apoptosis. This study used tissue microarrays to investigate the expression and localization of YY1 in 1364 representative tissue samples from 246 hormone naïve prostate cancer patients who underwent radical prostatectomy. Staining intensity and frequency measures for both YY1 nuclear and cytoplasmic expression were higher in neoplastic tissues and in PIN samples compared to matched benign cells (p<0.0001 for all comparisons). Expression of YY1 is predominantly elevated in early malignancy (PIN), as well as in tumors of intermediate to high morphologic grade (Gleason's grade 3-5). Using multivariate Cox proportional hazards analysis, we observed that low nuclear YY1 staining is an independent predictor of a shorter time to recurrence (p=0.012). Based on these results, we hypothesize that YY1 may play a role in prostate cancer development; however, decreased YY1 may give metastatic cells a survival advantage. These results may also implicate YY1 as a useful diagnostic and prognostic marker.

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Copy and paste a formatted citation
Spandidos Publications style
Seligson D, Horvath S, Huerta-Yepez S, Hanna S, Garban H, Roberts A, Shi T, Liu X, Chia D, Goodglick L, Goodglick L, et al: Expression of transcription factor Yin Yang 1 in prostate cancer. Int J Oncol 27: 131-141, 2005.
APA
Seligson, D., Horvath, S., Huerta-Yepez, S., Hanna, S., Garban, H., Roberts, A. ... Bonavida, B. (2005). Expression of transcription factor Yin Yang 1 in prostate cancer. International Journal of Oncology, 27, 131-141. https://doi.org/10.3892/ijo.27.1.131
MLA
Seligson, D., Horvath, S., Huerta-Yepez, S., Hanna, S., Garban, H., Roberts, A., Shi, T., Liu, X., Chia, D., Goodglick, L., Bonavida, B."Expression of transcription factor Yin Yang 1 in prostate cancer". International Journal of Oncology 27.1 (2005): 131-141.
Chicago
Seligson, D., Horvath, S., Huerta-Yepez, S., Hanna, S., Garban, H., Roberts, A., Shi, T., Liu, X., Chia, D., Goodglick, L., Bonavida, B."Expression of transcription factor Yin Yang 1 in prostate cancer". International Journal of Oncology 27, no. 1 (2005): 131-141. https://doi.org/10.3892/ijo.27.1.131
Copy and paste a formatted citation
x
Spandidos Publications style
Seligson D, Horvath S, Huerta-Yepez S, Hanna S, Garban H, Roberts A, Shi T, Liu X, Chia D, Goodglick L, Goodglick L, et al: Expression of transcription factor Yin Yang 1 in prostate cancer. Int J Oncol 27: 131-141, 2005.
APA
Seligson, D., Horvath, S., Huerta-Yepez, S., Hanna, S., Garban, H., Roberts, A. ... Bonavida, B. (2005). Expression of transcription factor Yin Yang 1 in prostate cancer. International Journal of Oncology, 27, 131-141. https://doi.org/10.3892/ijo.27.1.131
MLA
Seligson, D., Horvath, S., Huerta-Yepez, S., Hanna, S., Garban, H., Roberts, A., Shi, T., Liu, X., Chia, D., Goodglick, L., Bonavida, B."Expression of transcription factor Yin Yang 1 in prostate cancer". International Journal of Oncology 27.1 (2005): 131-141.
Chicago
Seligson, D., Horvath, S., Huerta-Yepez, S., Hanna, S., Garban, H., Roberts, A., Shi, T., Liu, X., Chia, D., Goodglick, L., Bonavida, B."Expression of transcription factor Yin Yang 1 in prostate cancer". International Journal of Oncology 27, no. 1 (2005): 131-141. https://doi.org/10.3892/ijo.27.1.131
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