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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 2005 Volume 27 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2005 Volume 27 Issue 2

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Article

Doxorubicin induces apoptosis with profile of large-scale DNA fragmentation and without DNA ladder in anaplastic thyroid carcinoma cells via histone hyperacetylation

  • Authors:
    • Jee Hyun Rho
    • Do-Young Kang
    • Ki Jae Park
    • Hong Jo Choi
    • Hyung Sik Lee
    • Su-Bog Yee
    • Young Hyun Yoo

  • View Affiliations / Copyright

    Affiliations: Department of Anatomy and Cell Biology, Institute of Cell Death and Differentiation, Dong-A University College of Medicine (BK21 program) and Medical Science Research Center, Busan, South Korea
  • Pages: 465-471
    |
    Published online on: August 1, 2005
       https://doi.org/10.3892/ijo.27.2.465
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Abstract

Doxorubicin is known to be the most effective single cytotoxic drug against anaplastic thyroid carcinoma (ATC). Although doxorubicin has been shown to cause cell death, at least partly, by inducing apoptosis in ATC cells, the mechanism underlying its pharmacological efficacy has not been fully delineated. We, in this study, revealed that doxorubicin induced apoptosis in ATC cells by altering the acetylation state of histone. Doxorubicin reduced histone deacetylase activity and induced hyperacetylation of histone 3. Noticeably, ladder-like DNA fragments from their genomic DNA on agarose gel were not detected irrespective of several lines of evidence supporting the induction of apoptosis. Pulse field electrophoresis showed disintegration of nuclear DNA into giant fragments of 1-2 Mbp and high molecular-weight fragments of 100-1000 kbp. We next examined whether a histone deacetylase inhibitor trichostatin A (TsA) augmented doxorubicin-induced apoptosis in ATC cells. TSA potentiated doxorubicin-induced stage I apoptosis in ATC cells. Our study sheds light on the development of a new combination therapy strategy for more effective responses for ATC treatment.

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Copy and paste a formatted citation
Spandidos Publications style
Rho JH, Kang D, Park KJ, Choi HJ, Lee HS, Yee S and Yoo YH: Doxorubicin induces apoptosis with profile of large-scale DNA fragmentation and without DNA ladder in anaplastic thyroid carcinoma cells via histone hyperacetylation. Int J Oncol 27: 465-471, 2005.
APA
Rho, J.H., Kang, D., Park, K.J., Choi, H.J., Lee, H.S., Yee, S., & Yoo, Y.H. (2005). Doxorubicin induces apoptosis with profile of large-scale DNA fragmentation and without DNA ladder in anaplastic thyroid carcinoma cells via histone hyperacetylation. International Journal of Oncology, 27, 465-471. https://doi.org/10.3892/ijo.27.2.465
MLA
Rho, J. H., Kang, D., Park, K. J., Choi, H. J., Lee, H. S., Yee, S., Yoo, Y. H."Doxorubicin induces apoptosis with profile of large-scale DNA fragmentation and without DNA ladder in anaplastic thyroid carcinoma cells via histone hyperacetylation". International Journal of Oncology 27.2 (2005): 465-471.
Chicago
Rho, J. H., Kang, D., Park, K. J., Choi, H. J., Lee, H. S., Yee, S., Yoo, Y. H."Doxorubicin induces apoptosis with profile of large-scale DNA fragmentation and without DNA ladder in anaplastic thyroid carcinoma cells via histone hyperacetylation". International Journal of Oncology 27, no. 2 (2005): 465-471. https://doi.org/10.3892/ijo.27.2.465
Copy and paste a formatted citation
x
Spandidos Publications style
Rho JH, Kang D, Park KJ, Choi HJ, Lee HS, Yee S and Yoo YH: Doxorubicin induces apoptosis with profile of large-scale DNA fragmentation and without DNA ladder in anaplastic thyroid carcinoma cells via histone hyperacetylation. Int J Oncol 27: 465-471, 2005.
APA
Rho, J.H., Kang, D., Park, K.J., Choi, H.J., Lee, H.S., Yee, S., & Yoo, Y.H. (2005). Doxorubicin induces apoptosis with profile of large-scale DNA fragmentation and without DNA ladder in anaplastic thyroid carcinoma cells via histone hyperacetylation. International Journal of Oncology, 27, 465-471. https://doi.org/10.3892/ijo.27.2.465
MLA
Rho, J. H., Kang, D., Park, K. J., Choi, H. J., Lee, H. S., Yee, S., Yoo, Y. H."Doxorubicin induces apoptosis with profile of large-scale DNA fragmentation and without DNA ladder in anaplastic thyroid carcinoma cells via histone hyperacetylation". International Journal of Oncology 27.2 (2005): 465-471.
Chicago
Rho, J. H., Kang, D., Park, K. J., Choi, H. J., Lee, H. S., Yee, S., Yoo, Y. H."Doxorubicin induces apoptosis with profile of large-scale DNA fragmentation and without DNA ladder in anaplastic thyroid carcinoma cells via histone hyperacetylation". International Journal of Oncology 27, no. 2 (2005): 465-471. https://doi.org/10.3892/ijo.27.2.465
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