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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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International Journal of Oncology

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
August 2005 Volume 27 Issue 2

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Journal Metrics

Impact Factor: 4.9

CiteScore: 8.9

CiteScore Rank: Q1: #66/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Article

Diverse gene expression pattern during 5-fluorouridine-induced apoptosis

Thomas D. Schmittgen, Kari A. Gissel, Brian A. Zakrajsek, B. Paige Lawrence, Qian Liu, Eldon R. Jupe, Megan R. Lerner, Son V. Do, Daniel J. Brackett
Pages: 297-306
Published online on: 01 August 2005

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Article

INSL3 in the benign hyperplastic and neoplastic human prostate gland

Thomas Klonisch, Harald Müller-Huesmann, Maria Riedel, Astrid Kehlen, Joanna Bialek, Yvonne Radestock, Hans-Juergen Holzhausen, Klaus Steger, Martin Ludwig, Wolfgang Weidner, Cuong Hoang-Vu, Sabine Hombach-Klonisch
Pages: 307-315
Published online on: 01 August 2005

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Article

Coexpression, prognostic significance and predictive value of EGFR, EGFRvIII and phosphorylated EGFR in colorectal cancer

Matthew P. Cunningham, Sharadah Essapen, Hilary Thomas, Margaret Green, David P. Lovell, Clare Topham, Christopher Marks, Helmout Modjtahedi
Pages: 317-325
Published online on: 01 August 2005

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Article

Potential of endogenous estrogen receptor β to influence the selective ER modulator ERβ complex

Bin Chen, Csaba Gajdos, Rita Dardes, Noman Kidwai, Stephen R.D. Johnston, Mitchell Dowsett, V. Craig Jordan
Pages: 327-335
Published online on: 01 August 2005

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Article

Assessment of the significance of mitochondrial DNA damage by chemotherapeutic agents

Soo Lo, Berend Tolner, Jan-Willem Taanman, J. Mark Cooper, Mei Gu, John A. Hartley, Anthony H.V. Schapira, Daniel Hochhauser
Pages: 337-344
Published online on: 01 August 2005

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Article

Apoptosis in cryopreserved human ovarian tissue obtained from cancer patients: A tool for evaluating cryopreservation utility

E. Rimon, T. Cohen, A. Dantes, L. Hirsh, A. Amit, J. B. Lessing, S. Freimann, A. Amsterdam, F. Azem
Pages: 345-353
Published online on: 01 August 2005

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Article

Detection of cryptic chromosomal aberrations in the in vitro non-proliferating cells of acute myeloid leukemia

Constanze Karst, Anita Heller, Uwe Claussen, Erich Gebhart, Thomas Liehr
Pages: 355-359
Published online on: 01 August 2005

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Article

Establishment of a new human epithelioid sarcoma cell line, FU-EPS-1: Molecular cytogenetic characterization by use of spectral karyotyping and comparative genomic hybridization

Jun Nishio, Hiroshi Iwasaki, Kazuki Nabeshima, Masako Ishiguro, Sabine Naumann, Teruto Isayama, Masatoshi Naito, Yasuhiko Kaneko, Masahiro Kikuchi, Julia A. Bridge
Pages: 361-369
Published online on: 01 August 2005

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Article

Prediction of chemosensitivity of colorectal cancer to 5-fluorouracil by gene expression profiling with cDNA microarrays

Daisuke Shimizu, Takashi Ishikawa, Yasushi Ichikawa, Shinji Togo, Yoshihide Hayasizaki, Yasushi Okazaki, Peter. V Danenberg, Hiroshi Shimada
Pages: 371-376
Published online on: 01 August 2005

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Article

Tumor-targeted gene transfer in vivo via recombinant Newcastle disease virus modified by a bispecific fusion protein

Huijie Bian, Philippe Fournier, Ben Peeters, Volker Schirrmacher
Pages: 377-384
Published online on: 01 August 2005

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Article

High-throughput tissue microarray analysis of COX2 expression in urinary bladder cancer

Peter J. Wild, Leoni A. Kunz-Schughart, Robert Stoehr, Maximilian Burger, Hagen Blaszyk, Ronald Simon, Thomas Gasser, Michael Mihatsch, Guido Sauter, Arndt Hartmann
Pages: 385-391
Published online on: 01 August 2005

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Article

HIF-1α attenuates tumor growth in spite of augmented vascularization in an A549 adenocarcinoma mouse model

Rajkumar Savai, Ralph Theo Schermuly, Robert Voswinckel, Aparna Renigunta, Bernd Reichmann, Bastian Eul, Friedrich Grimminger, Werner Seeger, Frank Rose, Jörg Hänze
Pages: 393-400
Published online on: 01 August 2005

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Article

Bone morphogenetic protein 2 (BMP-2) induces in vitro invasion and in vivo hormone independent growth of breast carcinoma cells

Joachim H. Clement, Martin Raida, Jörg Sänger, Roy Bicknell, Jingwen Liu, Anke Naumann, Annette Geyer, Anja Waldau, Peter Hortschansky, Andreas Schmidt, Klaus Höffken, Stefan Wölft, Adrian L. Harris
Pages: 401-407
Published online on: 01 August 2005

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Article

Correlation of expression of nuclear proteins pKi67 and p63 with lectin histochemical features in head and neck squamous cell cancer

Martin Chovanec, Karel Smetana, Jan Betka, Jan Plzák, Jirí Brabec, Violeta Moya-Álvarez, Sabine André, Roman Kodet, Hans-Joachim Gabius
Pages: 409-415
Published online on: 01 August 2005

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Article

Genomic screens for genes upregulated by demethylation in colorectal cancer: possible usefulness for clinical application

Kazuhiko Ogawa, Tohru Utsunomiya, Koshi Mimori, Keishi Yamashita, Masahiro Okamoto, Fumiaki Tanaka, Hiroshi Inoue, Yoichi Ikeda, Motonori Saku, Sadayuki Murayama, Masaki Mori
Pages: 417-426
Published online on: 01 August 2005

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Article

Anti-tumour effects of triple therapy with octreotide, galanin and serotonin in comparison with those of 5-fluorouracil/leukovorin on human colon cancer

Veronica Tjomsland, Magdy El-Salhy
Pages: 427-432
Published online on: 01 August 2005

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Article

Antitumor activity of cationic liposome-mediated Bax gene transfer in osteosarcoma cells: Induction of apoptosis and caspase-independent cell death

Kenya Okumura, Minoru Nakase, Shinnosuke Nakamura, Madoka Inui, Kenichi Hiramoto, Toshiro Tagawa
Pages: 433-438
Published online on: 01 August 2005

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Article

c-erbB2-induced epithelial-mesenchymal transition in mammary epithelial cells is suppressed by cell-cell contact and initiated prior to E-cadherin downregulation

Lachmi E. Jenndahl, Petter Isakson, Dan Baeckström
Pages: 439-448
Published online on: 01 August 2005

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Article

Potentiation of the antitumor activity of α, α, α-trifluorothymidine by the co-administration of an inhibitor of thymidine phosphorylase at a suitable molar ratio in vivo

Tomohiro Emura, Norihiko Suzuki, Akio Fujioka, Hideyuki Ohshimo, Masakazu Fukushima
Pages: 449-455
Published online on: 01 August 2005

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Article

Cancer gene therapy using in vivo electroporation of Flt3-ligand

Kazuya Shimao, Takuya Takayama, Katsuhisa Enomoto, Tetsuya Saito, Shigenori Nagai, Jun-Ichi Miyazaki, Kenji Ogawa, Hideaki Tahara
Pages: 457-463
Published online on: 01 August 2005

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Article

Doxorubicin induces apoptosis with profile of large-scale DNA fragmentation and without DNA ladder in anaplastic thyroid carcinoma cells via histone hyperacetylation

Jee Hyun Rho, Do-Young Kang, Ki Jae Park, Hong Jo Choi, Hyung Sik Lee, Su-Bog Yee, Young Hyun Yoo
Pages: 465-471
Published online on: 01 August 2005

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Article

Induction of apoptosis by trichostatin A, a histone deacetylase inhibitor, is associated with inhibition of cyclooxygenase-2 activity in human non-small cell lung cancer cells

Yung Hyun Choi
Pages: 473-479
Published online on: 01 August 2005

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Article

Deletions at chromosome 2q and 12p are early and frequent molecular alterations in bronchial epithelium and NSCLC of long-term smokers

Ulrike Grepmeier, Wolfgang Dietmaier, Johannes Merk, Peter J. Wild, Ellen C. Obermann, Michael Pfeifer, Ferdinand Hofstaedter, Arndt Hartmann, Matthias Woenckhaus
Pages: 481-488
Published online on: 01 August 2005

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Article

Possible role of glutathione in mitochondrial apoptosis of human oral squamous cell carcinoma caused by inorganic selenium compounds

Masato Takahashi, Tomonori Sato, Fumiaki Shinohara, Seishi Echigo, Hidemi Rikiishi
Pages: 489-495
Published online on: 01 August 2005

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Article

15-Deoxy-Δ12, 14-prostaglandin J2 activates the expression of p15INK4b gene, a cyclin-dependent kinase inhibitor

Youichirou Matsuzaki, Makoto Koyama, Toshiaki Hitomi, Yuuki Takaoka, Mayumi Kawanaka, Toshiyuki Sakai
Pages: 497-503
Published online on: 01 August 2005

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Article

Vitamins K2, K3 and K5 exert in vivo antitumor effects on hepatocellular carcinoma by regulating the expression of G1 phase-related cell cycle molecules

Shigeki Kuriyama, Misuzu Hitomi, Hitoshi Yoshiji, Takako Nonomura, Tatsuhiro Tsujimoto, Akira Mitoro, Takami Akahane, Mutsumi Ogawa, Seiji Nakai, Akihiro Deguchi, Tsutomu Masaki, Naohito Uchida
Pages: 505-511
Published online on: 01 August 2005

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Article

Molecular characterization of Coriolus versicolor PSP-induced apoptosis in human promyelotic leukemic HL-60 cells using cDNA microarray

Fanya Zeng, Chung-Chau Hon, Wai-Hung Sit, Ken Yan-Ching Chow, Raymond Kin-Hi Hui, Ivy Ka-Man Law, Victor Wai-Lap Ng, Xiao-Tong Yang, Frederick Chi-Ching Leung, Jennifer Man-Fan Wan
Pages: 513-523
Published online on: 01 August 2005

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Article

Generation of an immortalized human endothelial cell line as a model of neovascular proliferating endothelial cells to assess chemosensitivity to anticancer drugs

Lucio Tentori, Matteo Vergati, Alessia Muzi, Lauretta Levati, Federica Ruffini, Olindo Forini, Patrizia Vernole, Pedro Miguel Lacal, Grazia Graziani
Pages: 525-535
Published online on: 01 August 2005

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Article

Arsenic trioxide mediates intrinsic and extrinsic pathways of apoptosis and cell cycle arrest in acute megakaryocytic leukemia

Hubert Kin Bong Lam, Karen Li, Ki Wai Chik, Mo Yang, Venus Chi Ting Liu, Chi Kong Li, Tai Fai Fok, Pak Cheung Ng, Matthew Ming Kong Shing, Carmen Ka Yee Chuen, Patrick Man Pan Yuen
Pages: 537-545
Published online on: 01 August 2005

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Article

DHPLC based fraction collection of TCR-γ rearrangments in childhood ALL: Direct sequencing of products amplified by a single or a multiplex PCR approach

Udo Zur Stadt, Hendrik Isbarn, Reinhard Schneppenheim, Hartmut Kabisch
Pages: 547-552
Published online on: 01 August 2005

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Article

Increased anticancer activity of the thymidylate synthase inhibitor BGC9331 combined with the topoisomerase I inhibitor SN-38 in human colorectal and breast cancer cells: Induction of apoptosis and ROCK cleavage through caspase-3-dependent and -independent mechanisms

Anne-Marie Coudray, Christophe Louvet, Michel Kornprobst, Eric Raymond, Thierry André, Christophe Tournigand, Sandrine Faivre, Aimery De Gramont, Annette K. Larsen, Christian Gespach
Pages: 553-561
Published online on: 01 August 2005

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Review

Anti-angiogenic strategies for cancer therapy (Review)

Malika Benouchan, Bruno M. Colombo
Pages: 563-571
Published online on: 01 August 2005

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Article

Acquisition of Fas resistance by Fas receptor mutation in a childhood B-precursor acute lymphoblastic leukemia cell line, MML-1

Hiroto Inaba, Keiji Shimada, Yan-Wen Zhou, Masaru Ido, Steven Buck, Shin Yonehara, Joseph Kaplan, Yoshihiro Komada
Pages: 573-579
Published online on: 01 August 2005

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Article

Comparative genomics on BMP4 orthologs

Yuriko Katoh, Masaru Katoh
Pages: 581-585
Published online on: 01 August 2005

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Journal Cover
January-2026 Volume 68 Issue 1

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Journal Metrics

Impact Factor: 4.9

CiteScore: 8.9

CiteScore Rank: Q1: #66/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Article Open Access

c‑Myc‑regulated RPLP0 via the ROS‑mediated JAK2/STAT3 positive feedback loop facilitates hepatocellular carcinoma malignancy progression

Yanqiu Meng, Lebin Yuan, Gangrui Meng, Hongxiang Huang, Xianbin Huang, Xinping Xu, Xiaodong Peng
Article Number: 13
Published online on: 27 November 2025

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Review Open Access

Obesity, chronic breast inflammation and carcinogenesis: Molecular pathways and clinical implications (Review)

Fangying Li, Zhenhua Gao
Article Number: 12
Published online on: 27 November 2025

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Review Open Access

The tumor microenvironment in lung cancer: Heterogeneity, therapeutic resistance and emerging treatment strategies (Review)

Li Liu, Li Yang, Hongmin Li, Tianlu Shang, Lihan Liu
Article Number: 11
Published online on: 26 November 2025

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Article Open Access

Discovery of the late autophagy inhibitor FZU‑0045‑053 and its anti‑breast cancer and immunomodulatory effects

Jinlan Luo, Yi Yang, Lulu Cheng, Fangting Cheng, Huangwenlong Zhuang, Shanshan Chen, Panpan Qiao, Yinbin Liang, Li Chen, Yang Sun, Haijun Chen, Qinying Liu
Article Number: 10
Published online on: 26 November 2025

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Correction Open Access

[Corrigendum] RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling

Zi-Hao Qi, Hua-Xiang Xu, Shi-Rong Zhang, Jin-Zhi Xu, Shuo Li, He-Li Gao, Wei Jin, Wen-Quan Wang, Chun-Tao Wu, Quan-Xing Ni, Xian-Jun Yu, Liang Liu
Article Number: 9
Published online on: 24 November 2025

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Article Open Access

Ephrin‑B2 promotes gastric cancer growth by inhibiting apoptosis and regulating the cell cycle via the Wnt/β‑catenin signaling pathway

Ding Ding, Xiaoshan Wang, Ran Xuan, Rui Li, Yalu Zhang, Zhengguang Wang
Article Number: 8
Published online on: 18 November 2025

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Expression of Concern Open Access

[Expression of Concern] Gene therapy for human colorectal cancer cell lines with recombinant adenovirus 5 based on loss of the insulin‑like growth factor 2 imprinting

Huiling Sun, Yuqin Pan, Bangshun He, Qiwen Deng, Rui Li, Yeqiong Xu, Jie Chen, Tianyi Gao, Houqun Ying, Feng Wang, Xian Liu, Shukui Wang
Article Number: 7
Published online on: 18 November 2025

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Review Open Access

Ferroptosis in biliary tract cancer: Molecular mechanisms and therapeutic applications (Review)

Ruiqi Zou, Yushi Dai, Siqi Yang, Haijie Hu, Fuyu Li, Fei Liu
Article Number: 6
Published online on: 14 November 2025

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Expression of Concern Open Access

[Expression of Concern] Radiosensitization of esophageal carcinoma cells by knockdown of RNF2 expression

Xing-Xiao Yang, Ming Ma, Mei-Xiang Sang, Xue-Xiao Wang, Heng Song, Zhi-Kun Liu, Shu-Chai Zhu
Article Number: 5
Published online on: 10 November 2025

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Review Open Access

Targeting ferroptosis in Helicobacter pylori‑associated gastric cancer development: From molecular mechanisms to application prospects (Review)

Chen-Yi Wang, Meng-Hui Wang, Chuan Xie
Article Number: 4
Published online on: 05 November 2025

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Expression of Concern Open Access

[Expression of Concern] Leptin promotes breast cancer cell migration and invasion via IL‑18 expression and secretion

Kuangfa Li, Lan Wei, Yunxiu Huang, Yang Wu, Min Su, Xueli Pang, Nian Wang, Feihu Ji, Changli Zhong, Tingmei Chen
Article Number: 3
Published online on: 04 November 2025

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Review Open Access

Cancer immunotherapy strategies based on transition‑metal medical materials: Still a long way to go (Review)

Zhefei Du, Zhenyu Cao, Chao Fang, Daihan Xie, Lixin Xie, Chunxia Su, Yu Huo
Article Number: 2
Published online on: 04 November 2025

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Expression of Concern Open Access

[Expression of Concern] Regulation of NADPH oxidase (Nox2) by lipid rafts in breast carcinoma cells

Rama Rao Malla, Hari Raghu, Jasti S. Rao
Article Number: 1
Published online on: 23 October 2025

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Journal Cover
February-2026 Volume 68 Issue 2

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Journal Metrics

Impact Factor: 4.9

CiteScore: 8.9

CiteScore Rank: Q1: #66/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.955

SCImago Journal Rank (SJR): 1226.0

Retraction Open Access

[Retracted] Cdc42 expression in cervical cancer and its effects on cervical tumor invasion and migration

Hongnan Ye, Youyi Zhang, Li Geng, Zijian Li
Article Number: 20
Published online on: 05 December 2025

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Article Open Access

Regulation and reversal of paclitaxel resistance via the STAT1‑mediated apoptotic pathway in ovarian cancer

Fanchen Wang, Xiaolin Xu, Bin Guan, Xin Li, Jia Yuan, Wencai Guan, Junyu Chen, Jingyi Fang, Qi Lu, Guoxiong Xu
Article Number: 19
Published online on: 05 December 2025

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Review

Cancer stem cell heterogeneity‑inspired therapeutics for enhancing tumor treatment outcomes (Review)

Hanning Xu, Qunchao Si, Yongyao Song, Shengping Sun, Xianghong Wei, Hui Long, Xiaomei Wang
Article Number: 18
Published online on: 04 December 2025

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Review Open Access

Roles of interleukins in spasmolytic polypeptide‑expressing metaplasia (Review)

Jiale Ma, Tiancheng Zhan, Xinyuan Zhang, Wang Gao, Shuangmei Zhao, Huizhen Li
Article Number: 17
Published online on: 03 December 2025

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Expression of Concern Open Access

[Expression of Concern] MUC1 is a downstream target of STAT3 and regulates lung cancer cell survival and invasion

Jingchun Gao, Matthew J. Mcconnell, Bin Yu, Jiannong Li, Justin M. Balko, Esther P. Black, Joseph O. Johnson, Mark C. Lloyd, Soner Altiok, Eric B. Haura
Article Number: 16
Published online on: 03 December 2025

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Review Open Access

Emerging biomarkers in prostate cancer diagnosis and treatment: Insights into genetic, RNA and metabolic markers (Review)

Yuanshe Huang, Jingxin Mao, Xiaobing Li
Article Number: 15
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] GDC‑0152 attenuates the malignant progression of osteosarcoma promoted by ANGPTL2 via PI3K/AKT but not p38MAPK signaling pathway

Lin Yang, Taipengfei Shu, Yingjian Liang, Wenguang Gu, Chunlei Wang, Xuanhe Song, Changdong Fan, Wenbo Wang
Article Number: 14
Published online on: 01 December 2025

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