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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 2005 Volume 27 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2005 Volume 27 Issue 2

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Article

Possible role of glutathione in mitochondrial apoptosis of human oral squamous cell carcinoma caused by inorganic selenium compounds

  • Authors:
    • Masato Takahashi
    • Tomonori Sato
    • Fumiaki Shinohara
    • Seishi Echigo
    • Hidemi Rikiishi

  • View Affiliations / Copyright

    Affiliations: Department of Microbiology and Immunology, Tohoku University Graduate School of Dentistry, Aoba-ku, Sendai 980-8575, Japan
  • Pages: 489-495
    |
    Published online on: August 1, 2005
       https://doi.org/10.3892/ijo.27.2.489
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Abstract

Selenium (Se) is a very effective anti-cancer agent. We studied the effects of inorganic Se compounds on induction of apoptosis by which Se compounds exert cancer chemopreventive activity. With the use of HSC-3 human oral squamous cell carcinoma cells, the present study showed that treatment with Se for 72 h, in the form of SeO2 and Na2SeO3, but not Na2SeO4, markedly induced apoptosis in a dose-dependent manner. Treatment of HSC-3 cells with 100 µM SeO2 resulted in the caspase-3-like and -9-like activation. Se compounds induced a loss of mitochondrial membrane potential (ΔΨm), but did not induce the generation of reactive oxygen species. Treatment with SeO2 for 18 h resulted in 80% loss of reduced glutathione (GSH), which is known to be involved in the metabolism of Se. Treatment with N-acetyl-L-cysteine, or exogenous GSH, prevented the SeO2-induced apoptosis. Treatment with GSH led to the partial reverse in reduction of ΔΨm caused by SeO2, while buthionine sulfoximine augmented the SeO2- or Na2SeO3-induced apoptosis.These results suggest that modulation of the mitochondrial redox equilibrium by Se contributes to the mitochondrial pathway, regulating caspase-9-mediated apoptosis without a concurrent increase in ROS.

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Copy and paste a formatted citation
Spandidos Publications style
Takahashi M, Sato T, Shinohara F, Echigo S and Rikiishi H: Possible role of glutathione in mitochondrial apoptosis of human oral squamous cell carcinoma caused by inorganic selenium compounds. Int J Oncol 27: 489-495, 2005.
APA
Takahashi, M., Sato, T., Shinohara, F., Echigo, S., & Rikiishi, H. (2005). Possible role of glutathione in mitochondrial apoptosis of human oral squamous cell carcinoma caused by inorganic selenium compounds. International Journal of Oncology, 27, 489-495. https://doi.org/10.3892/ijo.27.2.489
MLA
Takahashi, M., Sato, T., Shinohara, F., Echigo, S., Rikiishi, H."Possible role of glutathione in mitochondrial apoptosis of human oral squamous cell carcinoma caused by inorganic selenium compounds". International Journal of Oncology 27.2 (2005): 489-495.
Chicago
Takahashi, M., Sato, T., Shinohara, F., Echigo, S., Rikiishi, H."Possible role of glutathione in mitochondrial apoptosis of human oral squamous cell carcinoma caused by inorganic selenium compounds". International Journal of Oncology 27, no. 2 (2005): 489-495. https://doi.org/10.3892/ijo.27.2.489
Copy and paste a formatted citation
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Spandidos Publications style
Takahashi M, Sato T, Shinohara F, Echigo S and Rikiishi H: Possible role of glutathione in mitochondrial apoptosis of human oral squamous cell carcinoma caused by inorganic selenium compounds. Int J Oncol 27: 489-495, 2005.
APA
Takahashi, M., Sato, T., Shinohara, F., Echigo, S., & Rikiishi, H. (2005). Possible role of glutathione in mitochondrial apoptosis of human oral squamous cell carcinoma caused by inorganic selenium compounds. International Journal of Oncology, 27, 489-495. https://doi.org/10.3892/ijo.27.2.489
MLA
Takahashi, M., Sato, T., Shinohara, F., Echigo, S., Rikiishi, H."Possible role of glutathione in mitochondrial apoptosis of human oral squamous cell carcinoma caused by inorganic selenium compounds". International Journal of Oncology 27.2 (2005): 489-495.
Chicago
Takahashi, M., Sato, T., Shinohara, F., Echigo, S., Rikiishi, H."Possible role of glutathione in mitochondrial apoptosis of human oral squamous cell carcinoma caused by inorganic selenium compounds". International Journal of Oncology 27, no. 2 (2005): 489-495. https://doi.org/10.3892/ijo.27.2.489
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