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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 2005 Volume 27 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2005 Volume 27 Issue 3

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Article

Suppression of tumor growth in human gastric cancer with HER2 overexpression by an anti-HER2 antibody in a murine model

  • Authors:
    • Yoko Matsui
    • Masafumi Inomata
    • Manabu Tojigamori
    • Kazuya Sonoda
    • Norio Shiraishi
    • Seigo Kitano

  • View Affiliations / Copyright

    Affiliations: Department of Surgery I, Oita University Faculty of Medicine, Hasama-machi, Oita 879-5593, Japan. skyyoko@med.oita-u.ac.jp
  • Pages: 681-685
    |
    Published online on: September 1, 2005
       https://doi.org/10.3892/ijo.27.3.681
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Abstract

New modalities are necessary for the treatment of patients with unresectable gastric cancer. The aim of this study was to investigate whether or not anti-HER2 antibody could suppress the growth of human gastric cancer cells with HER2 overexpression in vitro and in vivo. Four human gastric cancer cell lines, NCI-N87, MKN-45P, Kato-III, and MKN-1, were used in this study. The suppression of cell proliferation in vitro and of subcutaneous tumor growth in a nude mouse model after treatment with trastuzumab was examined. The expression of HER2 protein was investigated by Western blot analysis. The effect of trastuzumab on the survival rate of nude mice with peritoneal dissemination was examined. Trastuzumab significantly reduced proliferative activity in NCI-N87, a HER2-overexpressing human gastric cancer cell line, in vitro. In the nude mouse model with transplanted subcutaneous tumor, trastuzumab significantly suppressed the tumor growth of NCI-N87 cells, and then HER2 expression was reduced. Trastuzumab improved the survival rate of mice with peritoneal dissemination of MKN-45P cells. Trastuzumab therapy is a potential candidate for a novel treatment of HER2-overexpressing gastric cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Matsui Y, Inomata M, Tojigamori M, Sonoda K, Shiraishi N and Kitano S: Suppression of tumor growth in human gastric cancer with HER2 overexpression by an anti-HER2 antibody in a murine model. Int J Oncol 27: 681-685, 2005.
APA
Matsui, Y., Inomata, M., Tojigamori, M., Sonoda, K., Shiraishi, N., & Kitano, S. (2005). Suppression of tumor growth in human gastric cancer with HER2 overexpression by an anti-HER2 antibody in a murine model. International Journal of Oncology, 27, 681-685. https://doi.org/10.3892/ijo.27.3.681
MLA
Matsui, Y., Inomata, M., Tojigamori, M., Sonoda, K., Shiraishi, N., Kitano, S."Suppression of tumor growth in human gastric cancer with HER2 overexpression by an anti-HER2 antibody in a murine model". International Journal of Oncology 27.3 (2005): 681-685.
Chicago
Matsui, Y., Inomata, M., Tojigamori, M., Sonoda, K., Shiraishi, N., Kitano, S."Suppression of tumor growth in human gastric cancer with HER2 overexpression by an anti-HER2 antibody in a murine model". International Journal of Oncology 27, no. 3 (2005): 681-685. https://doi.org/10.3892/ijo.27.3.681
Copy and paste a formatted citation
x
Spandidos Publications style
Matsui Y, Inomata M, Tojigamori M, Sonoda K, Shiraishi N and Kitano S: Suppression of tumor growth in human gastric cancer with HER2 overexpression by an anti-HER2 antibody in a murine model. Int J Oncol 27: 681-685, 2005.
APA
Matsui, Y., Inomata, M., Tojigamori, M., Sonoda, K., Shiraishi, N., & Kitano, S. (2005). Suppression of tumor growth in human gastric cancer with HER2 overexpression by an anti-HER2 antibody in a murine model. International Journal of Oncology, 27, 681-685. https://doi.org/10.3892/ijo.27.3.681
MLA
Matsui, Y., Inomata, M., Tojigamori, M., Sonoda, K., Shiraishi, N., Kitano, S."Suppression of tumor growth in human gastric cancer with HER2 overexpression by an anti-HER2 antibody in a murine model". International Journal of Oncology 27.3 (2005): 681-685.
Chicago
Matsui, Y., Inomata, M., Tojigamori, M., Sonoda, K., Shiraishi, N., Kitano, S."Suppression of tumor growth in human gastric cancer with HER2 overexpression by an anti-HER2 antibody in a murine model". International Journal of Oncology 27, no. 3 (2005): 681-685. https://doi.org/10.3892/ijo.27.3.681
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