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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 2005 Volume 27 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2005 Volume 27 Issue 3

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Article

NF-κB activation contributes to anthracycline resistance pathway in human ovarian carcinoma cell line A2780

  • Authors:
    • Carmela Salvatore
    • Grazia Camarda
    • Carlo Alberto Maggi
    • Cristina Goso
    • Stefano Manzini
    • Monica Binaschi

  • View Affiliations / Copyright

    Affiliations: Menarini Ricerche, 00040 Pomezia, Rome, Italy
  • Pages: 799-806
    |
    Published online on: September 1, 2005
       https://doi.org/10.3892/ijo.27.3.799
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Abstract

The development of chemoresistance is a major obstacle for successful anticancer therapy. Understanding the molecular mechanisms leading to chemoresistance is a rational step to improve the therapeutic efficacy of cytotoxic drugs. Since anthracyclines play an important role in cancer chemotherapy, we have generated a human ovarian tumor cell line resistant to sabarubicin (MEN 10755), the newest anthracycline molecule in clinical development. Expression of the transporter protein MRP that affected sabarubicin uptake, and a reduced DNA topoisomerase II content in A2780/saba cells was observed. Since the poisoning of DNA topoisomerase II results in DNA damage, which is a critical signal for NF-κB activation, we explored if this transcription factor has a role in the chemoresistance to anthracyclines. We showed a reduced NF-κB activation in the resistant cell line. Moreover, qualitative changes in NF-κB dimer formation between the two cell lines were observed. In agreement with the hypothesis of a role of NF-κB in mediating drug resistance, we showed that the pharmacological inhibition of NF-κB activation attenuated drug resistance in A2780/saba cells whereas it had no effect in A2780 cells. Altogether, these findings show that anthracycline resistance in A2780 cell lines is due to the coexpression of several molecular mechanisms.

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Copy and paste a formatted citation
Spandidos Publications style
Salvatore C, Camarda G, Maggi CA, Goso C, Manzini S and Binaschi M: NF-κB activation contributes to anthracycline resistance pathway in human ovarian carcinoma cell line A2780. Int J Oncol 27: 799-806, 2005.
APA
Salvatore, C., Camarda, G., Maggi, C.A., Goso, C., Manzini, S., & Binaschi, M. (2005). NF-κB activation contributes to anthracycline resistance pathway in human ovarian carcinoma cell line A2780. International Journal of Oncology, 27, 799-806. https://doi.org/10.3892/ijo.27.3.799
MLA
Salvatore, C., Camarda, G., Maggi, C. A., Goso, C., Manzini, S., Binaschi, M."NF-κB activation contributes to anthracycline resistance pathway in human ovarian carcinoma cell line A2780". International Journal of Oncology 27.3 (2005): 799-806.
Chicago
Salvatore, C., Camarda, G., Maggi, C. A., Goso, C., Manzini, S., Binaschi, M."NF-κB activation contributes to anthracycline resistance pathway in human ovarian carcinoma cell line A2780". International Journal of Oncology 27, no. 3 (2005): 799-806. https://doi.org/10.3892/ijo.27.3.799
Copy and paste a formatted citation
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Spandidos Publications style
Salvatore C, Camarda G, Maggi CA, Goso C, Manzini S and Binaschi M: NF-κB activation contributes to anthracycline resistance pathway in human ovarian carcinoma cell line A2780. Int J Oncol 27: 799-806, 2005.
APA
Salvatore, C., Camarda, G., Maggi, C.A., Goso, C., Manzini, S., & Binaschi, M. (2005). NF-κB activation contributes to anthracycline resistance pathway in human ovarian carcinoma cell line A2780. International Journal of Oncology, 27, 799-806. https://doi.org/10.3892/ijo.27.3.799
MLA
Salvatore, C., Camarda, G., Maggi, C. A., Goso, C., Manzini, S., Binaschi, M."NF-κB activation contributes to anthracycline resistance pathway in human ovarian carcinoma cell line A2780". International Journal of Oncology 27.3 (2005): 799-806.
Chicago
Salvatore, C., Camarda, G., Maggi, C. A., Goso, C., Manzini, S., Binaschi, M."NF-κB activation contributes to anthracycline resistance pathway in human ovarian carcinoma cell line A2780". International Journal of Oncology 27, no. 3 (2005): 799-806. https://doi.org/10.3892/ijo.27.3.799
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