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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2005 Volume 27 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2005 Volume 27 Issue 4

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Review

Old and new insights into the mechanisms of action of two nucleoside analogs active in lymphoid malignancies: fludarabine and cladribine (Review)

  • Authors:
    • Eric Van Den Neste
    • Sabine Cardoen
    • Fritz Offner
    • Françoise Bontemps

  • View Affiliations / Copyright

    Affiliations: Laboratory of Physiological Chemistry, Christian de Duve Institute of Cellular Pathology, UCL-ICP 7539, 1200 Brussels, Belgium. vandenneste@sang.ucl.ac.be
  • Pages: 1113-1124
    |
    Published online on: October 1, 2005
       https://doi.org/10.3892/ijo.27.4.1113
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Abstract

This review focuses on two chemotherapeutic agents belonging to the family of purine analogs, 9-β-D-arabinosyl-2-fluoroadenine-5'-monophosphate (F-ara-AMP, fludarabine), which is the soluble form of F-ara-A, and 2-chloro-2'-deoxyadenosine (CdA, cladribine). Both compounds display remarkable activity in malignancies arising from the clonal expansion of lymphocytes, and particularly in B-cell chronic lymphocytic leukemia (B-CLL). These analogs are prodrugs that must be converted into their respective nucleotides as an essential requirement for cytotoxicity. Triphosphate analogs inhibit various processes involved in DNA and RNA synthesis. Moreover, the effect of nucleoside analogs in leukemic cells may involve modulation of apoptosis pathways, cell-cycle control, or signal transduction pathways. These findings are of crucial importance because alterations in these pathways may be involved in leukemic cell resistance toward nucleoside analogs and, hence, constitute new molecular targets to sensitize leukemic cells to these drugs.

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Copy and paste a formatted citation
Spandidos Publications style
Van Den Neste E, Cardoen S, Offner F and Bontemps F: Old and new insights into the mechanisms of action of two nucleoside analogs active in lymphoid malignancies: fludarabine and cladribine (Review). Int J Oncol 27: 1113-1124, 2005.
APA
Van Den Neste, E., Cardoen, S., Offner, F., & Bontemps, F. (2005). Old and new insights into the mechanisms of action of two nucleoside analogs active in lymphoid malignancies: fludarabine and cladribine (Review). International Journal of Oncology, 27, 1113-1124. https://doi.org/10.3892/ijo.27.4.1113
MLA
Van Den Neste, E., Cardoen, S., Offner, F., Bontemps, F."Old and new insights into the mechanisms of action of two nucleoside analogs active in lymphoid malignancies: fludarabine and cladribine (Review)". International Journal of Oncology 27.4 (2005): 1113-1124.
Chicago
Van Den Neste, E., Cardoen, S., Offner, F., Bontemps, F."Old and new insights into the mechanisms of action of two nucleoside analogs active in lymphoid malignancies: fludarabine and cladribine (Review)". International Journal of Oncology 27, no. 4 (2005): 1113-1124. https://doi.org/10.3892/ijo.27.4.1113
Copy and paste a formatted citation
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Spandidos Publications style
Van Den Neste E, Cardoen S, Offner F and Bontemps F: Old and new insights into the mechanisms of action of two nucleoside analogs active in lymphoid malignancies: fludarabine and cladribine (Review). Int J Oncol 27: 1113-1124, 2005.
APA
Van Den Neste, E., Cardoen, S., Offner, F., & Bontemps, F. (2005). Old and new insights into the mechanisms of action of two nucleoside analogs active in lymphoid malignancies: fludarabine and cladribine (Review). International Journal of Oncology, 27, 1113-1124. https://doi.org/10.3892/ijo.27.4.1113
MLA
Van Den Neste, E., Cardoen, S., Offner, F., Bontemps, F."Old and new insights into the mechanisms of action of two nucleoside analogs active in lymphoid malignancies: fludarabine and cladribine (Review)". International Journal of Oncology 27.4 (2005): 1113-1124.
Chicago
Van Den Neste, E., Cardoen, S., Offner, F., Bontemps, F."Old and new insights into the mechanisms of action of two nucleoside analogs active in lymphoid malignancies: fludarabine and cladribine (Review)". International Journal of Oncology 27, no. 4 (2005): 1113-1124. https://doi.org/10.3892/ijo.27.4.1113
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