Distinct expression of Survivin splice variants in breast carcinomas

  • Authors:
    • Frédérique Vegran
    • Romain Boidot
    • Claire Oudin
    • Jean-Marc Riedinger
    • Sarab Lizard-Nacol
  • View Affiliations

  • Published online on: October 1, 2005     https://doi.org/10.3892/ijo.27.4.1151
  • Pages: 1151-1157
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Abstract

Survivin, a member of the inhibitor apoptosis family, is expressed in several human tumours, and its expression is regulated by p53. Recently, three alternative splice variants (Survivin-2B, Survivin-ΔEx3 and Survivin-3B), differing in their antiapoptotic properties, were identified. To date, little is known about the expression of all Survivin splice variants in breast cancer, particularly the recently identified Survivin-3B variant. In this study, we show that all Survivin transcripts were expressed in breast tumour cell lines and breast carcinomas, with a very weak expression detected in adjacent normal tissue. Frequency of proapoptotic Survivin-2B was significantly higher in small tumour size (p=0.026) and was inversely associated with axillary node positive carcinomas (p=0.004). In contrast, Survivin-3B was more frequent in high-grade carcinomas (p=0.004). Correlation with p53 status revealed that Survivin-3B was significantly more frequent in carcinomas with p53 gene mutation (p=0.036). After neoadjuvant chemotherapy, a significant reduction in the percentage of expressing Survivin (p=0.016) and Survivin-2B (p=0.027) was observed, while no change was found for Survivin-ΔEx3 and Survivin-3B variants. These results demonstrate for the first time that Survivin variants are differentially expressed in breast cancer according to tumour progression and treatment and suggest that Survivin-3B might act as an antiapoptotic factor in this lesion, with its expression regulated by p53.

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October 2005
Volume 27 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Vegran F, Boidot R, Oudin C, Riedinger J and Lizard-Nacol S: Distinct expression of Survivin splice variants in breast carcinomas. Int J Oncol 27: 1151-1157, 2005.
APA
Vegran, F., Boidot, R., Oudin, C., Riedinger, J., & Lizard-Nacol, S. (2005). Distinct expression of Survivin splice variants in breast carcinomas. International Journal of Oncology, 27, 1151-1157. https://doi.org/10.3892/ijo.27.4.1151
MLA
Vegran, F., Boidot, R., Oudin, C., Riedinger, J., Lizard-Nacol, S."Distinct expression of Survivin splice variants in breast carcinomas". International Journal of Oncology 27.4 (2005): 1151-1157.
Chicago
Vegran, F., Boidot, R., Oudin, C., Riedinger, J., Lizard-Nacol, S."Distinct expression of Survivin splice variants in breast carcinomas". International Journal of Oncology 27, no. 4 (2005): 1151-1157. https://doi.org/10.3892/ijo.27.4.1151