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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2005 Volume 27 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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November 2005 Volume 27 Issue 5

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Article

Selective accumulation and strong photodynamic effects of a new photosensitizer, ATX-S10·Na (II), in experimental malignant glioma

  • Authors:
    • Junkoh Yamamoto
    • Toru Hirano
    • Shaoyi Li
    • Masayo Koide
    • Eiji Kohno
    • Chikanori Inenaga
    • Tsutomu Tokuyama
    • Naoki Yokota
    • Seiji Yamamoto
    • Susumu Terakawa
    • Hiroki Namba
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan
  • Pages: 1207-1213
    |
    Published online on: November 1, 2005
       https://doi.org/10.3892/ijo.27.5.1207
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Abstract

We investigated the feasibility of a novel photosensitizer, ATX-S10·Na (II), in photodynamic therapy (PDT) for glioma. First, PDT was performed in various brain tumor cell lines in vitro. Cytotoxicity depended upon both drug concentration and laser energy and the 50% inhibitory concentration ranged from 3.5 to 20 µg/ml. Next, PDT was performed in the subcutaneous and intracranial 9L tumor models in Fischer rats using ATX-S10·Na (II) and light from a 670-nm diode laser delivered by intratumoral insertion of an optical fiber. The effect of PDT on brain tumors was evaluated using magnetic resonance imaging. Sequential changes of the ATX-S10·Na (II) concentrations were also measured quantitatively by fluorospectrometry up to 12 h after intravenous administration in rats with intracranial and subcutaneous tumors. The concentration of ATX-S10·Na (II) in the brain tumor reached a maximum at 2 h after administration and the tumor/normal brain concentration ratio was as high as 131 at 8 h. Intratumoral PDT for intracranial tumors irradiated at this timing showed an obvious anti-tumor effect without severe side effects. The present study demonstrated the highly selective accumulation of ATX-S10·Na (II) in tumor tissue and its potent photodynamic effect in an experimental malignant glioma model.

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Copy and paste a formatted citation
Spandidos Publications style
Yamamoto J, Hirano T, Li S, Koide M, Kohno E, Inenaga C, Tokuyama T, Yokota N, Yamamoto S, Terakawa S, Terakawa S, et al: Selective accumulation and strong photodynamic effects of a new photosensitizer, ATX-S10·Na (II), in experimental malignant glioma. Int J Oncol 27: 1207-1213, 2005.
APA
Yamamoto, J., Hirano, T., Li, S., Koide, M., Kohno, E., Inenaga, C. ... Namba, H. (2005). Selective accumulation and strong photodynamic effects of a new photosensitizer, ATX-S10·Na (II), in experimental malignant glioma. International Journal of Oncology, 27, 1207-1213. https://doi.org/10.3892/ijo.27.5.1207
MLA
Yamamoto, J., Hirano, T., Li, S., Koide, M., Kohno, E., Inenaga, C., Tokuyama, T., Yokota, N., Yamamoto, S., Terakawa, S., Namba, H."Selective accumulation and strong photodynamic effects of a new photosensitizer, ATX-S10·Na (II), in experimental malignant glioma". International Journal of Oncology 27.5 (2005): 1207-1213.
Chicago
Yamamoto, J., Hirano, T., Li, S., Koide, M., Kohno, E., Inenaga, C., Tokuyama, T., Yokota, N., Yamamoto, S., Terakawa, S., Namba, H."Selective accumulation and strong photodynamic effects of a new photosensitizer, ATX-S10·Na (II), in experimental malignant glioma". International Journal of Oncology 27, no. 5 (2005): 1207-1213. https://doi.org/10.3892/ijo.27.5.1207
Copy and paste a formatted citation
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Spandidos Publications style
Yamamoto J, Hirano T, Li S, Koide M, Kohno E, Inenaga C, Tokuyama T, Yokota N, Yamamoto S, Terakawa S, Terakawa S, et al: Selective accumulation and strong photodynamic effects of a new photosensitizer, ATX-S10·Na (II), in experimental malignant glioma. Int J Oncol 27: 1207-1213, 2005.
APA
Yamamoto, J., Hirano, T., Li, S., Koide, M., Kohno, E., Inenaga, C. ... Namba, H. (2005). Selective accumulation and strong photodynamic effects of a new photosensitizer, ATX-S10·Na (II), in experimental malignant glioma. International Journal of Oncology, 27, 1207-1213. https://doi.org/10.3892/ijo.27.5.1207
MLA
Yamamoto, J., Hirano, T., Li, S., Koide, M., Kohno, E., Inenaga, C., Tokuyama, T., Yokota, N., Yamamoto, S., Terakawa, S., Namba, H."Selective accumulation and strong photodynamic effects of a new photosensitizer, ATX-S10·Na (II), in experimental malignant glioma". International Journal of Oncology 27.5 (2005): 1207-1213.
Chicago
Yamamoto, J., Hirano, T., Li, S., Koide, M., Kohno, E., Inenaga, C., Tokuyama, T., Yokota, N., Yamamoto, S., Terakawa, S., Namba, H."Selective accumulation and strong photodynamic effects of a new photosensitizer, ATX-S10·Na (II), in experimental malignant glioma". International Journal of Oncology 27, no. 5 (2005): 1207-1213. https://doi.org/10.3892/ijo.27.5.1207
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