Selective accumulation and strong photodynamic effects of a new photosensitizer, ATX-S10·Na (II), in experimental malignant glioma

  • Authors:
    • Junkoh Yamamoto
    • Toru Hirano
    • Shaoyi Li
    • Masayo Koide
    • Eiji Kohno
    • Chikanori Inenaga
    • Tsutomu Tokuyama
    • Naoki Yokota
    • Seiji Yamamoto
    • Susumu Terakawa
    • Hiroki Namba
  • View Affiliations

  • Published online on: November 1, 2005     https://doi.org/10.3892/ijo.27.5.1207
  • Pages: 1207-1213
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Abstract

We investigated the feasibility of a novel photosensitizer, ATX-S10·Na (II), in photodynamic therapy (PDT) for glioma. First, PDT was performed in various brain tumor cell lines in vitro. Cytotoxicity depended upon both drug concentration and laser energy and the 50% inhibitory concentration ranged from 3.5 to 20 µg/ml. Next, PDT was performed in the subcutaneous and intracranial 9L tumor models in Fischer rats using ATX-S10·Na (II) and light from a 670-nm diode laser delivered by intratumoral insertion of an optical fiber. The effect of PDT on brain tumors was evaluated using magnetic resonance imaging. Sequential changes of the ATX-S10·Na (II) concentrations were also measured quantitatively by fluorospectrometry up to 12 h after intravenous administration in rats with intracranial and subcutaneous tumors. The concentration of ATX-S10·Na (II) in the brain tumor reached a maximum at 2 h after administration and the tumor/normal brain concentration ratio was as high as 131 at 8 h. Intratumoral PDT for intracranial tumors irradiated at this timing showed an obvious anti-tumor effect without severe side effects. The present study demonstrated the highly selective accumulation of ATX-S10·Na (II) in tumor tissue and its potent photodynamic effect in an experimental malignant glioma model.

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November 2005
Volume 27 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Yamamoto J, Hirano T, Li S, Koide M, Kohno E, Inenaga C, Tokuyama T, Yokota N, Yamamoto S, Terakawa S, Terakawa S, et al: Selective accumulation and strong photodynamic effects of a new photosensitizer, ATX-S10·Na (II), in experimental malignant glioma. Int J Oncol 27: 1207-1213, 2005
APA
Yamamoto, J., Hirano, T., Li, S., Koide, M., Kohno, E., Inenaga, C. ... Namba, H. (2005). Selective accumulation and strong photodynamic effects of a new photosensitizer, ATX-S10·Na (II), in experimental malignant glioma. International Journal of Oncology, 27, 1207-1213. https://doi.org/10.3892/ijo.27.5.1207
MLA
Yamamoto, J., Hirano, T., Li, S., Koide, M., Kohno, E., Inenaga, C., Tokuyama, T., Yokota, N., Yamamoto, S., Terakawa, S., Namba, H."Selective accumulation and strong photodynamic effects of a new photosensitizer, ATX-S10·Na (II), in experimental malignant glioma". International Journal of Oncology 27.5 (2005): 1207-1213.
Chicago
Yamamoto, J., Hirano, T., Li, S., Koide, M., Kohno, E., Inenaga, C., Tokuyama, T., Yokota, N., Yamamoto, S., Terakawa, S., Namba, H."Selective accumulation and strong photodynamic effects of a new photosensitizer, ATX-S10·Na (II), in experimental malignant glioma". International Journal of Oncology 27, no. 5 (2005): 1207-1213. https://doi.org/10.3892/ijo.27.5.1207