Expression of SIP1 in oral squamous cell carcinomas: implications for E-cadherin expression and tumor progression

Maeda,Genta; Chiba,Tadashige; Okazaki,Masahiro; Satoh,Tazuko; Taya,Yuji; Aoba,Takaaki; Kato,Koroku; Kawashiri,Shuichi; Imai,Kazushi

doi:10.3892/ijo.27.6.1535

December 2005 Volume 27 Issue 6

Full Size Image

Cover Legend PDF

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

December 2005 Volume 27 Issue 6

Full Size Image

Cover Legend PDF

Article

Expression of SIP1 in oral squamous cell carcinomas: implications for E-cadherin expression and tumor progression

Authors:
- Genta Maeda
- Tadashige Chiba
- Masahiro Okazaki
- Tazuko Satoh
- Yuji Taya
- Takaaki Aoba
- Koroku Kato
- Shuichi Kawashiri
- Kazushi Imai
View Affiliations / Copyright

Affiliations: Department of Biochemistry, School of Dentistry at Tokyo, The Nippon Dental University, Tokyo, Japan
Pages: 1535-1541
|
Published online on: December 1, 2005

https://doi.org/10.3892/ijo.27.6.1535
Expand metrics +

Abstract

Loss of E-cadherin expression allows carcinoma cells to liberate from the primary site and enhances invasion and metastasis. The genetic aberration of E-cadherin is a rare event in sporadic carcinomas, and transcription repressors are considered to take a central role in E-cadherin loss. However, expression of E-cadherin repressors is largely dependent on tissue and cell type. To identify the repressor expressed in oral squamous carcinomas, we compared the expression levels of E-cadherin and repressors by real-time RT-PCR. Among the repressors including SNAIL, SLUG, SIP1, E12 and E47, SIP1 was inversely correlated to E-cadherin (P<0.05). Chromatin immunoprecipitation showed that SIP1 specifically bound to the E-cadherin promoter region. SIP1 expression was immuno-histochemically detected in 27.7% of 47 oral carcinomas, and SIP1-positive carcinomas did not express E-cadherin (P<0.01). Thirteen patients with SIP1 staining showed a lower disease-specific survival rate (P<0.05). Multivariate risk factor analysis demonstrated that SIP1 expression was an independent prognostic value for disease-specific overall survival (P<0.05). These results suggest that SIP1 contributes to the loss of E-cadherin expression and that detection of SIP1 expression is a predictive and prognostic tool in clinical management of oral carcinomas.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Expression of SIP1 in oral squamous cell carcinomas: implications for E-cadherin expression and tumor progression

This article is mentioned in:

Abstract

Related Articles