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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2005 Volume 27 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2005 Volume 27 Issue 6

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Article

Hypericin: a promising fluorescence marker for differentiating between glioblastoma and neurons in vitro

  • Authors:
    • Rainer Ritz
    • Martin Müller
    • Michael Weller
    • Klaus Dietz
    • Selim Kuci
    • Florian Roser
    • Marcos Tatagiba

  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, University Hospital Tuebingen, 72076 Tuebingen, Germany. rainer.ritz@med.uni-tuebingen.de
  • Pages: 1543-1549
    |
    Published online on: December 1, 2005
       https://doi.org/10.3892/ijo.27.6.1543
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Abstract

The naturally occurring photosensitizer, hypericin, with its high quantum yield of singlet oxygen photogeneration was studied for its ability to differentiate between glioblastoma cells and fetal rat neurons using fluorescence microscopy. Eight human glioma cell lines and twelve primary human glioma cell cultures were compared to human astrocytes and cerebellar granule neurons after incubation with 20 µM hypericin for 5-120 min. Photobleaching effects have been studied by exposing the cell lines to 100 msec of excitation light (510-550 wavelength). Mainly, perinuclear hypericin staining was detected. Neurons can be differentiated from glioblastoma cell lines and astrocytes by a lower fluorescence intensity (Tukey-Kramer HSD test, p<0.0001). Therefore, hypericin seems to be a promising substance for the photodynamic therapy of malignant brain tumors.

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Copy and paste a formatted citation
Spandidos Publications style
Ritz R, Müller M, Weller M, Dietz K, Kuci S, Roser F and Tatagiba M: Hypericin: a promising fluorescence marker for differentiating between glioblastoma and neurons in vitro. Int J Oncol 27: 1543-1549, 2005.
APA
Ritz, R., Müller, M., Weller, M., Dietz, K., Kuci, S., Roser, F., & Tatagiba, M. (2005). Hypericin: a promising fluorescence marker for differentiating between glioblastoma and neurons in vitro. International Journal of Oncology, 27, 1543-1549. https://doi.org/10.3892/ijo.27.6.1543
MLA
Ritz, R., Müller, M., Weller, M., Dietz, K., Kuci, S., Roser, F., Tatagiba, M."Hypericin: a promising fluorescence marker for differentiating between glioblastoma and neurons in vitro". International Journal of Oncology 27.6 (2005): 1543-1549.
Chicago
Ritz, R., Müller, M., Weller, M., Dietz, K., Kuci, S., Roser, F., Tatagiba, M."Hypericin: a promising fluorescence marker for differentiating between glioblastoma and neurons in vitro". International Journal of Oncology 27, no. 6 (2005): 1543-1549. https://doi.org/10.3892/ijo.27.6.1543
Copy and paste a formatted citation
x
Spandidos Publications style
Ritz R, Müller M, Weller M, Dietz K, Kuci S, Roser F and Tatagiba M: Hypericin: a promising fluorescence marker for differentiating between glioblastoma and neurons in vitro. Int J Oncol 27: 1543-1549, 2005.
APA
Ritz, R., Müller, M., Weller, M., Dietz, K., Kuci, S., Roser, F., & Tatagiba, M. (2005). Hypericin: a promising fluorescence marker for differentiating between glioblastoma and neurons in vitro. International Journal of Oncology, 27, 1543-1549. https://doi.org/10.3892/ijo.27.6.1543
MLA
Ritz, R., Müller, M., Weller, M., Dietz, K., Kuci, S., Roser, F., Tatagiba, M."Hypericin: a promising fluorescence marker for differentiating between glioblastoma and neurons in vitro". International Journal of Oncology 27.6 (2005): 1543-1549.
Chicago
Ritz, R., Müller, M., Weller, M., Dietz, K., Kuci, S., Roser, F., Tatagiba, M."Hypericin: a promising fluorescence marker for differentiating between glioblastoma and neurons in vitro". International Journal of Oncology 27, no. 6 (2005): 1543-1549. https://doi.org/10.3892/ijo.27.6.1543
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