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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2006 Volume 28 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2006 Volume 28 Issue 4

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Article

Significance of Id-1 up-regulation and its association with EGFR in bladder cancer cell invasion

  • Authors:
    • Yi Ding
    • Gang Wang
    • Ming Tat Ling
    • Y. C. Wong
    • Xin Li
    • Yanqun Na
    • Xiaomeng Zhang
    • Chee Wai Chua
    • Xianghong Wang
    • Dianqi Xin

  • View Affiliations / Copyright

    Affiliations: Cancer Biology Group, Department of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong, P.R. China
  • Pages: 847-854
    |
    Published online on: April 1, 2006
       https://doi.org/10.3892/ijo.28.4.847
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Abstract

Epidermal growth factor receptor (EGFR) is suggested to be one of the positive factors in the invasive progression of bladder cancer. Id-1 (inhibitor of differentiation or DNA binding), a helix-loop-helix (HLH) transcription factor, was recently identified as a key factor in the EGFR signalling pathway. The aim of this study was to investigate the role of Id-1 in bladder cancer progression and its relation-ship with EGFR. Using clinical specimens from different stages of bladder cancer, immunohistochemical staining was performed to determine if Id-1 expression was positively associated with tumour staging and EGFR expression. The direct role of Id-1 in cancer cell invasion was also investigated through ectopically expressing the Id-1 gene in a RT112 bladder cancer cell line by wound closure and collagen invasion assays. To explore the therapeutic potential of targeting the Id-1 gene in the treatment of invasive bladder cancer, we studied if inactivation of the Id-1 gene through small RNA interference could lead to the suppression of invasion in a MGHU1 bladder cancer cell line. Our results showed that the up-regulation of Id-1 was associated with increased EGFR expression, clinical staging and the invasion ability of bladder cancer cells. Inactivation of Id-1 may be a potential therapeutic target to inhibit the invasion by bladder cancer cells.

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Copy and paste a formatted citation
Spandidos Publications style
Ding Y, Wang G, Ling MT, Wong YC, Li X, Na Y, Zhang X, Chua CW, Wang X, Xin D, Xin D, et al: Significance of Id-1 up-regulation and its association with EGFR in bladder cancer cell invasion. Int J Oncol 28: 847-854, 2006.
APA
Ding, Y., Wang, G., Ling, M.T., Wong, Y.C., Li, X., Na, Y. ... Xin, D. (2006). Significance of Id-1 up-regulation and its association with EGFR in bladder cancer cell invasion. International Journal of Oncology, 28, 847-854. https://doi.org/10.3892/ijo.28.4.847
MLA
Ding, Y., Wang, G., Ling, M. T., Wong, Y. C., Li, X., Na, Y., Zhang, X., Chua, C. W., Wang, X., Xin, D."Significance of Id-1 up-regulation and its association with EGFR in bladder cancer cell invasion". International Journal of Oncology 28.4 (2006): 847-854.
Chicago
Ding, Y., Wang, G., Ling, M. T., Wong, Y. C., Li, X., Na, Y., Zhang, X., Chua, C. W., Wang, X., Xin, D."Significance of Id-1 up-regulation and its association with EGFR in bladder cancer cell invasion". International Journal of Oncology 28, no. 4 (2006): 847-854. https://doi.org/10.3892/ijo.28.4.847
Copy and paste a formatted citation
x
Spandidos Publications style
Ding Y, Wang G, Ling MT, Wong YC, Li X, Na Y, Zhang X, Chua CW, Wang X, Xin D, Xin D, et al: Significance of Id-1 up-regulation and its association with EGFR in bladder cancer cell invasion. Int J Oncol 28: 847-854, 2006.
APA
Ding, Y., Wang, G., Ling, M.T., Wong, Y.C., Li, X., Na, Y. ... Xin, D. (2006). Significance of Id-1 up-regulation and its association with EGFR in bladder cancer cell invasion. International Journal of Oncology, 28, 847-854. https://doi.org/10.3892/ijo.28.4.847
MLA
Ding, Y., Wang, G., Ling, M. T., Wong, Y. C., Li, X., Na, Y., Zhang, X., Chua, C. W., Wang, X., Xin, D."Significance of Id-1 up-regulation and its association with EGFR in bladder cancer cell invasion". International Journal of Oncology 28.4 (2006): 847-854.
Chicago
Ding, Y., Wang, G., Ling, M. T., Wong, Y. C., Li, X., Na, Y., Zhang, X., Chua, C. W., Wang, X., Xin, D."Significance of Id-1 up-regulation and its association with EGFR in bladder cancer cell invasion". International Journal of Oncology 28, no. 4 (2006): 847-854. https://doi.org/10.3892/ijo.28.4.847
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