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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2006 Volume 28 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Effects of PPAR and RXR ligands in semaphorin 6B gene expression of human MCF-7 breast cancer cells

  • Authors:
    • Hossam Murad
    • Philippe Collet
    • Cecile Huin-Schohn
    • Nehmann Al-Makdissy
    • Geraldine Kerjan
    • Alain Chedotal
    • Mireille Donner
    • Marie Dominique Devignes
    • Philippe Becuwe
    • Herve Schohn
    • Lionel Domenjoud
    • Michel Dauça

  • View Affiliations / Copyright

    Affiliations: EA 3446 ‘Peroxisome Proliferators’, Faculty of Sciences, BP 239, 54506 Vandoeuvre-les-Nancy, France. Hossam.Murad@scbiol.uhp-nancy.fr
  • Pages: 977-984
    |
    Published online on: April 1, 2006
       https://doi.org/10.3892/ijo.28.4.977
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Abstract

This study tests the hypothesis that the activators of peroxisome proliferator-activated receptors (PPARs) and 9-cis-retinoic acid receptor (RXR) regulate human semaphorin 6B (Sema6B) gene expression. The human MCF-7 breast adenocarcinoma cell line was chosen because it expresses Sema6B at a high level. The Sema6B mRNA level was analyzed by RT-PCR and the semaphorin 6B protein content was determined using a polyclonal antibody that we have produced and characterized. Treatments with fenofibrate (a PPARα activator) and troglitazone (a PPARγ ligand) strongly decreased the Sema6B mRNA. The drop in Sema6B mRNA level and in protein content was more important when the treatment combined the action of fenofibrate or troglitazone and 9-cis-retinoic acid. On the other hand, no significant change was observed in the Sema6B mRNA and protein levels when the cells were exposed to the combined action of GW610742 (a PPARβ activator) and 9-cis-retinoic acid. These data suggest that PPARα/RXR and PPARγ/RXR heterodimers are involved in the regulation of Sema6B gene expression and open new perspectives concerning the participation of these nuclear receptors in cell recognition and migration.

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Copy and paste a formatted citation
Spandidos Publications style
Murad H, Collet P, Huin-Schohn C, Al-Makdissy N, Kerjan G, Chedotal A, Donner M, Devignes MD, Becuwe P, Schohn H, Schohn H, et al: Effects of PPAR and RXR ligands in semaphorin 6B gene expression of human MCF-7 breast cancer cells. Int J Oncol 28: 977-984, 2006.
APA
Murad, H., Collet, P., Huin-Schohn, C., Al-Makdissy, N., Kerjan, G., Chedotal, A. ... Dauça, M. (2006). Effects of PPAR and RXR ligands in semaphorin 6B gene expression of human MCF-7 breast cancer cells. International Journal of Oncology, 28, 977-984. https://doi.org/10.3892/ijo.28.4.977
MLA
Murad, H., Collet, P., Huin-Schohn, C., Al-Makdissy, N., Kerjan, G., Chedotal, A., Donner, M., Devignes, M. D., Becuwe, P., Schohn, H., Domenjoud, L., Dauça, M."Effects of PPAR and RXR ligands in semaphorin 6B gene expression of human MCF-7 breast cancer cells". International Journal of Oncology 28.4 (2006): 977-984.
Chicago
Murad, H., Collet, P., Huin-Schohn, C., Al-Makdissy, N., Kerjan, G., Chedotal, A., Donner, M., Devignes, M. D., Becuwe, P., Schohn, H., Domenjoud, L., Dauça, M."Effects of PPAR and RXR ligands in semaphorin 6B gene expression of human MCF-7 breast cancer cells". International Journal of Oncology 28, no. 4 (2006): 977-984. https://doi.org/10.3892/ijo.28.4.977
Copy and paste a formatted citation
x
Spandidos Publications style
Murad H, Collet P, Huin-Schohn C, Al-Makdissy N, Kerjan G, Chedotal A, Donner M, Devignes MD, Becuwe P, Schohn H, Schohn H, et al: Effects of PPAR and RXR ligands in semaphorin 6B gene expression of human MCF-7 breast cancer cells. Int J Oncol 28: 977-984, 2006.
APA
Murad, H., Collet, P., Huin-Schohn, C., Al-Makdissy, N., Kerjan, G., Chedotal, A. ... Dauça, M. (2006). Effects of PPAR and RXR ligands in semaphorin 6B gene expression of human MCF-7 breast cancer cells. International Journal of Oncology, 28, 977-984. https://doi.org/10.3892/ijo.28.4.977
MLA
Murad, H., Collet, P., Huin-Schohn, C., Al-Makdissy, N., Kerjan, G., Chedotal, A., Donner, M., Devignes, M. D., Becuwe, P., Schohn, H., Domenjoud, L., Dauça, M."Effects of PPAR and RXR ligands in semaphorin 6B gene expression of human MCF-7 breast cancer cells". International Journal of Oncology 28.4 (2006): 977-984.
Chicago
Murad, H., Collet, P., Huin-Schohn, C., Al-Makdissy, N., Kerjan, G., Chedotal, A., Donner, M., Devignes, M. D., Becuwe, P., Schohn, H., Domenjoud, L., Dauça, M."Effects of PPAR and RXR ligands in semaphorin 6B gene expression of human MCF-7 breast cancer cells". International Journal of Oncology 28, no. 4 (2006): 977-984. https://doi.org/10.3892/ijo.28.4.977
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