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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 2006 Volume 28 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2006 Volume 28 Issue 5

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Article

Caspase-2: a possible trigger of apoptosis induced in A-549 tumor cells by ZnPc photodynamic treatment

  • Authors:
    • Javier Cristóbal
    • Juan C. Stockert
    • Angeles Villanueva
    • Santiago Rello-Varona
    • Angeles Juarranz
    • Magdalena Cañete

  • View Affiliations / Copyright

    Affiliations: Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain
  • Pages: 1057-1063
    |
    Published online on: May 1, 2006
       https://doi.org/10.3892/ijo.28.5.1057
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Abstract

Photodynamic therapy applied to cell cultures represents a widely accepted experimental method to investigate molecular mechanisms that lead to apoptotic cell death. In this context the subcellular localization of photosensitizers seems to be a significant factor in order to determine the apoptotic pathway that could be activated. We have characterized the experimental conditions that induce apoptotic cell death in A-549 cells incubated with ZnPc and irrradiated with red light. Previously we have found that in this cell line the drug is localized in the Golgi apparatus after 3-h incubation. Indirect immunofluorescence analysis of the events that lead to apoptosis made possible the detection of caspase-2 activation in the Golgi region immediately after photodynamic treatments. A few minutes later, the morphology of this organelle starts to disrupt and just 6 h after treatment the nuclei appear affected showing the fragmented appearance typical of apoptotic cell death. From this results we assume that following the photodynamic treatment of A-549 cells with ZnPc, the activation of caspase-2 in the Golgi apparatus could begin to initiate immediately the apoptotic process.

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Copy and paste a formatted citation
Spandidos Publications style
Cristóbal J, Stockert JC, Villanueva A, Rello-Varona S, Juarranz A and Cañete M: Caspase-2: a possible trigger of apoptosis induced in A-549 tumor cells by ZnPc photodynamic treatment. Int J Oncol 28: 1057-1063, 2006.
APA
Cristóbal, J., Stockert, J.C., Villanueva, A., Rello-Varona, S., Juarranz, A., & Cañete, M. (2006). Caspase-2: a possible trigger of apoptosis induced in A-549 tumor cells by ZnPc photodynamic treatment. International Journal of Oncology, 28, 1057-1063. https://doi.org/10.3892/ijo.28.5.1057
MLA
Cristóbal, J., Stockert, J. C., Villanueva, A., Rello-Varona, S., Juarranz, A., Cañete, M."Caspase-2: a possible trigger of apoptosis induced in A-549 tumor cells by ZnPc photodynamic treatment". International Journal of Oncology 28.5 (2006): 1057-1063.
Chicago
Cristóbal, J., Stockert, J. C., Villanueva, A., Rello-Varona, S., Juarranz, A., Cañete, M."Caspase-2: a possible trigger of apoptosis induced in A-549 tumor cells by ZnPc photodynamic treatment". International Journal of Oncology 28, no. 5 (2006): 1057-1063. https://doi.org/10.3892/ijo.28.5.1057
Copy and paste a formatted citation
x
Spandidos Publications style
Cristóbal J, Stockert JC, Villanueva A, Rello-Varona S, Juarranz A and Cañete M: Caspase-2: a possible trigger of apoptosis induced in A-549 tumor cells by ZnPc photodynamic treatment. Int J Oncol 28: 1057-1063, 2006.
APA
Cristóbal, J., Stockert, J.C., Villanueva, A., Rello-Varona, S., Juarranz, A., & Cañete, M. (2006). Caspase-2: a possible trigger of apoptosis induced in A-549 tumor cells by ZnPc photodynamic treatment. International Journal of Oncology, 28, 1057-1063. https://doi.org/10.3892/ijo.28.5.1057
MLA
Cristóbal, J., Stockert, J. C., Villanueva, A., Rello-Varona, S., Juarranz, A., Cañete, M."Caspase-2: a possible trigger of apoptosis induced in A-549 tumor cells by ZnPc photodynamic treatment". International Journal of Oncology 28.5 (2006): 1057-1063.
Chicago
Cristóbal, J., Stockert, J. C., Villanueva, A., Rello-Varona, S., Juarranz, A., Cañete, M."Caspase-2: a possible trigger of apoptosis induced in A-549 tumor cells by ZnPc photodynamic treatment". International Journal of Oncology 28, no. 5 (2006): 1057-1063. https://doi.org/10.3892/ijo.28.5.1057
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